INT82904

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Context Info
Confidence 0.00
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.30
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
brain 1
Crh (Rattus norvegicus)
ge (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 8 97.04 Very High Very High Very High
anesthesia 2 89.44 High High
Disease Link Frequency Relevance Heat
Gastric Motility Disorder 16 100.00 Very High Very High Very High
Ileus 2 95.76 Very High Very High Very High
Gastroparesis 2 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that CRF acts in the brain and periphery to inhibit GE through receptor-mediated interaction and that peripheral CRF is involved in acute postoperative gastric ileus; astressin is a potent peripheral antagonist of CRF when injected i.v. whereas i.c. doses >/=3 microgram exert dual central and peripheral blockade of CRF action on gastric transit.
CRF Negative_regulation (inhibit) of GE in brain associated with ileus, antagonist and gastric motility disorder
1) Confidence 0.00 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10411571 Disease Relevance 0.80 Pain Relevance 0.25
The 55% inhibition of GE induced by CRF (0.6 microgram i.v.) was antagonized by 87 and 100% by i.v. astressin at 3 and 10 microgram, respectively, and by 68 and 64% by i.v.
CRF Negative_regulation (inhibition) of GE associated with gastric motility disorder
2) Confidence 0.00 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10411571 Disease Relevance 0.50 Pain Relevance 0.08

General Comments

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