INT82913

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Context Info
Confidence 0.61
First Reported 1999
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 15
Total Number 19
Disease Relevance 10.66
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
Anatomy Link Frequency
plasma 1
Kidney 1
ovary 1
deck 1
Ppara (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 78 100.00 Very High Very High Very High
agonist 212 99.96 Very High Very High Very High
addiction 1 99.68 Very High Very High Very High
Hyperalgesia 2 97.40 Very High Very High Very High
cINOD 35 97.36 Very High Very High Very High
antagonist 25 89.60 High High
Antinociceptive 4 75.00 Quite High
cytokine 5 69.80 Quite High
allodynia 6 26.40 Quite Low
metalloproteinase 3 25.28 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 99 100.00 Very High Very High Very High
Hepatocellular Cancer 52 98.72 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

8 98.68 Very High Very High Very High
Cirrhosis 32 98.08 Very High Very High Very High
Apoptosis 200 98.04 Very High Very High Very High
Hyperalgesia 3 97.40 Very High Very High Very High
Coronary Heart Disease 42 96.56 Very High Very High Very High
Weight Gain 15 96.16 Very High Very High Very High
Colon Cancer 8 95.44 Very High Very High Very High
Overweight 3 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peroxisome proliferator activated receptors (PPAR) are ligand-regulated transcription factors that control the expression of many genes.
Regulation (regulated) of PPAR
1) Confidence 0.61 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17343847 Disease Relevance 0.21 Pain Relevance 0.23
In this review we will focus on the new insights gained into these two areas and we will also discuss our current knowledge of the regulation of PPAR transcriptional activity by cofactors.
Regulation (regulation) of PPAR
2) Confidence 0.54 Published 1999 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 10412372 Disease Relevance 0.32 Pain Relevance 0.24
Peroxisome proliferator activated receptors (PPAR) are ligand-regulated transcription factors that control the expression of many genes.
Regulation (control) of PPAR
3) Confidence 0.45 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17343847 Disease Relevance 0.27 Pain Relevance 0.24
One potential mechanism involves the PPAR?
Regulation (involves) of PPAR
4) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 1.12 Pain Relevance 0.47
agonists was not due to the direct cardiac effects of PPAR agonists, for example, activation of cardiac PPAR-?
Regulation (effects) of PPAR associated with agonist
5) Confidence 0.39 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 0.84 Pain Relevance 0.10
Based on their potent anti-inflammatory and antioxidation actions, the synthetic PPAR?
Regulation (Based) of PPAR associated with inflammation
6) Confidence 0.37 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.84 Pain Relevance 0.13
Effects of Chronic PPAR-Agonist Treatment on Cardiac Structure and Function, Blood Pressure, and Kidney in Healthy Sprague-Dawley Rats

PPAR-?

Regulation (Effects) of PPAR in Kidney associated with agonist
7) Confidence 0.34 Published 2009 Journal PPAR Research Section Title Doc Link PMC2696219 Disease Relevance 0.42 Pain Relevance 0.17
receptor and thus modulates the activity of PPAR-?
Regulation (modulates) of PPAR
8) Confidence 0.26 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2293961 Disease Relevance 0.44 Pain Relevance 0.04
In addition to their effects on glucose homeostasis and lipid metabolism [43], PPAR?
Regulation (effects) of PPAR
9) Confidence 0.25 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.69 Pain Relevance 0.06
We believe that elevated plasma adiponectin levels and cardiac dysfunction are two independent effects of PPAR-?
Neg (independent) Regulation (effects) of PPAR in plasma
10) Confidence 0.24 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 0.55 Pain Relevance 0.19
This study investigated the effects of several PPARalpha and PPARgamma subtype-specific agonists on the inflammation and hyperalgesia produced by intraplantar carrageenan injection in unanesthetized male Sprague-Dawley rats.
Spec (investigated) Regulation (effects) of PPARalpha associated with hyperalgesia, inflammation and agonist
11) Confidence 0.20 Published 2002 Journal Inflammation Section Abstract Doc Link 12083418 Disease Relevance 0.74 Pain Relevance 0.44
The mechanism that explains the effects of the peroxisome proliferator-activated receptor (PPAR) ?
Regulation (effects) of PPAR
12) Confidence 0.19 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.44 Pain Relevance 0
within ovarian cells and how this affects the activity of the latter PPAR isotypes will add to the knowledge of how these transcription factors are regulated in the ovary.
Regulation (affects) of PPAR in ovary
13) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.13 Pain Relevance 0
Investigating the influence of PPAR?
Spec (Investigating) Regulation (influence) of PPAR
14) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.28 Pain Relevance 0
Besides its effects on angiogenesis, PPAR?
Regulation (effects) of PPAR
15) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0 Pain Relevance 0.05
before we can draw any conclusions on PPAR?
Regulation (conclusions) of PPAR
16) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 0.95 Pain Relevance 0.08
Several in vitro and in vivo papers suggest a role of the PPAR?
Regulation (role) of PPAR
17) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 0.81 Pain Relevance 0.24
The new generation of dual-action PPARs – the glitazars, which target PPAR-gamma and PPAR-alpha (like muraglitazar and tesaglitazar) are on deck in late-stage clinical trials and may be effective in reducing cardiovascular risk, but their long-term clinical effects are still unknown.
Regulation (target) of PPAR in deck
18) Confidence 0.03 Published 2005 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC1236941 Disease Relevance 0.34 Pain Relevance 0.09
3.2. regulation of PPAR and Zn dependence for immune regulation of TNF [355]
Regulation (regulation) of PPAR associated with addiction
19) Confidence 0.01 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1820789 Disease Relevance 0.99 Pain Relevance 0.27

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