INT82928

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.54
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Eln) extracellular region (Eln) proteinaceous extracellular matrix (Eln)
extracellular matrix organization (Eln)
Anatomy Link Frequency
ligaments 1
bladders 1
skin 1
neural 1
Eln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 19 93.20 High High
Hyperalgesia 7 92.52 High High
Pain 12 92.40 High High
allodynia 13 91.84 High High
Neuropathic pain 57 66.80 Quite High
Spinal cord 11 64.56 Quite High
Lasting pain 5 62.08 Quite High
intrathecal 3 59.04 Quite High
Etanercept 4 56.64 Quite High
analgesia 2 37.20 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 57 97.64 Very High Very High Very High
Hypertension 16 95.60 Very High Very High Very High
Spinal Cord Injury 62 93.92 High High
Injury 51 93.68 High High
Hyperalgesia 12 92.52 High High
Pain 17 92.40 High High
Neuropathic Pain 76 91.84 High High
Pressure Volume 2 Under Development 1 88.40 High High
Wrinkles 5 87.20 High High
Erythema 1 83.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enalapril reduced aortic media wall thickness by 9% (p < 0.02) and increased elastin content by 22% (p < 0.03) and elastin-to-collagen content ratio by 42% (p < 0.01).
Positive_regulation (increased) of elastin
1) Confidence 0.69 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10413075 Disease Relevance 0.46 Pain Relevance 0
Up-regulation of tropoelastin and lysyl oxidase was further confirmed and quantified at the mRNA level using total RNA collected from three to four bladders each of normal and post-SCI (3 days, 7 days, and 25 days) rats and TaqMan analysis according to the standard protocols with the Mx3000P qPCR apparatus (Stratagene, La Jolla, CA), as described previously [10]. mRNA expression for tropoelastin and lysyl oxidase was found to be significantly higher at 3 and 7 days post-SCI as compared to normal, and returned to normal levels at 25 days.
Positive_regulation (Up-regulation) of tropoelastin in bladders associated with spinal cord injury
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.67 Pain Relevance 0
Resurfacing of cutaneous tissue with carbon dioxide laser increases the amount and quality of collagen and elastin subepithelially.
Positive_regulation (increases) of elastin
3) Confidence 0.21 Published 2009 Journal Br J Oral Maxillofac Surg Section Abstract Doc Link 18760514 Disease Relevance 0.06 Pain Relevance 0
Biomechanical measurements suggest that the laser treatment produced a skin state more similar to skin in younger patients, presumably with higher levels and/or greater organization of the collagen and elastin.
Positive_regulation (organization) of elastin in skin
4) Confidence 0.15 Published 2000 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 11083571 Disease Relevance 0.52 Pain Relevance 0.09
Similarly, transfer of IGF-1 cDNA by using an adenovirus vector led to the synthesis and deposition of increased amounts of types I and III collagen, elastin, tenascin, and vimentin in the same model[111]; thus confirming the potential of using vector-laden hydrogels for the in situ delivery of genes to damaged ligaments for potential biological repair of the ACL.


Positive_regulation (increased) of elastin in ligaments
5) Confidence 0.02 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2879239 Disease Relevance 0.07 Pain Relevance 0
This can be due to impaired glycemic control, microangiopathy or interstitial accumulation of elastin and collagen which also increase LV stiffness and mass in diabetic patients [30].
Positive_regulation (accumulation) of elastin associated with diabetes mellitus
6) Confidence 0.02 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2430540 Disease Relevance 0.90 Pain Relevance 0
Following a similar logic, a fusion protein (ELP-sTNFR2) has been developed wherein a soluble form of TNFR2 (sTNFR2) is conjugated to a temperature-sensitive elastin-like polypeptide (ELP), which can be thermally triggered to form a deposit around the peri-neural site of injection [172].
Positive_regulation (triggered) of elastin-like polypeptide in neural
7) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2861665 Disease Relevance 0.87 Pain Relevance 0.68

General Comments

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