INT82929

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 58
Total Number 59
Disease Relevance 26.96
Pain Relevance 13.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
cytoplasm (Plat)
Anatomy Link Frequency
astrocytes 12
nucleus accumbens 8
brain 4
ear 3
striatum 2
Plat (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 12 99.96 Very High Very High Very High
Morphine 68 99.74 Very High Very High Very High
Nucleus accumbens 72 99.68 Very High Very High Very High
Central nervous system 202 99.36 Very High Very High Very High
Multiple sclerosis 7 99.24 Very High Very High Very High
Inflammation 337 99.08 Very High Very High Very High
Hippocampus 12 99.06 Very High Very High Very High
Nicotine 4 98.48 Very High Very High Very High
addiction 21 98.12 Very High Very High Very High
cva 48 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stroke 592 99.92 Very High Very High Very High
Targeted Disruption 154 99.80 Very High Very High Very High
Pressure And Volume Under Development 221 99.76 Very High Very High Very High
Multiple Sclerosis 4 99.76 Very High Very High Very High
Urological Neuroanatomy 45 99.68 Very High Very High Very High
Coronary Artery Disease 8 99.52 Very High Very High Very High
Infarction 27 99.34 Very High Very High Very High
Demyelinating Disease 9 99.24 Very High Very High Very High
Embolism 21 99.12 Very High Very High Very High
INFLAMMATION 353 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A DNA microarray screening revealed that the expression levels of tissue plasminogen activator (tPA) mRNA in the nucleus accumbens of morphine- or methamphetamine-dependent rats were significantly increased compared with those in control animals.
Gene_expression (expression) of tissue plasminogen activator in nucleus accumbens associated with nucleus accumbens and morphine
1) Confidence 0.78 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.25 Pain Relevance 0.44
Repeated METH treatment dose-dependently induced tPA mRNA expression in the frontal cortex, nucleus accumbens, striatum and hippocampus, whereas single METH treatment did not affect tPA mRNA expression in these brain areas.
Gene_expression (expression) of tPA mRNA in striatum associated with nucleus accumbens, urological neuroanatomy and hippocampus
2) Confidence 0.77 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15659235 Disease Relevance 0.10 Pain Relevance 0.44
The METH-induced increase in tPA mRNA expression in the nucleus accumbens was completely inhibited by pre-treatment with R(+)-SCH23390 and raclopride, dopamine D1 and D2 receptor antagonists, respectively.
Gene_expression (expression) of tPA mRNA in nucleus accumbens associated with nucleus accumbens, dopamine and antagonist
3) Confidence 0.77 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15659235 Disease Relevance 0.09 Pain Relevance 0.45
Repeated METH treatment dose-dependently induced tPA mRNA expression in the frontal cortex, nucleus accumbens, striatum and hippocampus, whereas single METH treatment did not affect tPA mRNA expression in these brain areas.
Gene_expression (expression) of tPA mRNA in striatum associated with nucleus accumbens, urological neuroanatomy and hippocampus
4) Confidence 0.77 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15659235 Disease Relevance 0.10 Pain Relevance 0.43
The acute effect of morphine in inducing tPA expression was diminished after repeated administration.
Gene_expression (expression) of tPA associated with morphine
5) Confidence 0.76 Published 2006 Journal Nihon Arukoru Yakubutsu Igakkai Zasshi Section Abstract Doc Link 16619846 Disease Relevance 0.09 Pain Relevance 1.11
In this study, we measured tPA/PAI-1 expression and tPA activity in astrocytes cultured under normal and oxygen and glucose deprivation (OGD) conditions and co-cultured with or without MSCs as an in vitro ischemia model.
Gene_expression (expression) of tPA in astrocytes associated with ischemia
6) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.68 Pain Relevance 0.17
To knock-down the tPA expression in astrocytes, siRNA technique was employed.
Gene_expression (expression) of tPA in astrocytes associated with targeted disruption
7) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.10 Pain Relevance 0
Treatment of stroke with MSCs significantly increased tPA expression and decreased PAI-1 expression compared with PBS treatment. tPA activity in the MCAo control brain extract and in the MCAo MSC treated brain extract was measured using zymography.
Gene_expression (expression) of tPA in brain associated with middle cerebral artery infarction and stroke
8) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.84 Pain Relevance 0
To verify the neurite outgrowth promoting effect of tPA secreted by astrocytes, the siRNA technique was used to knock-down the tPA expression in astrocytes.
Gene_expression (expression) of tPA in astrocytes associated with targeted disruption
9) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.37 Pain Relevance 0
An increase of parenchymal cell expression of tPA early after stroke may be a negative factor for neural cell survival and for sustaining blood-brain barrier (BBB) integrity.
Gene_expression (expression) of tPA in parenchymal cell associated with stroke
10) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.95 Pain Relevance 0.16
MTPAKT) were used to detect the total tPA protein and active tPA level in conditioned media, respectively.
Gene_expression (detect) of tPA
11) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.20 Pain Relevance 0.03
Both growth promoting and growth-inhibitory molecules are upregulated within the peri-infarct region of the brain early after stroke [69]. tPA expression as well as its inhibitors PAI-1 and neuroserpin are up-regulated in the acute stage of cerebral ischemia and hemorrhage [13], [70], [71].
Gene_expression (expression) of tPA in brain associated with cv general 4 under development, stroke, ischemia and cva
12) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.90 Pain Relevance 0.16
Stroke significantly increased expression of tPA and PAI-1 in the ischemic hemisphere compared to non-ischemic brain (Fig. 4a, 4b).
Gene_expression (expression) of tPA in brain associated with stroke
13) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.74 Pain Relevance 0
In brain, tissue plasminogen activator (tPA) expression in astrocytes is the primary source of plasminogen activator and PAI-1 is the dominant inhibitor of tPA [21].
Gene_expression (expression) of tPA in astrocytes
14) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.45 Pain Relevance 0.16
The extracellular serine protease tissue plasminogen activator (tPA) that converts plasminogen into plasmin is abundantly expressed throughout the central nervous system.
Gene_expression (expressed) of tPA in central nervous system associated with central nervous system
15) Confidence 0.74 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15948318 Disease Relevance 0.14 Pain Relevance 0.70
Single and repeated morphine treatment as well as repeated methamphetamine treatment induced tPA mRNA expression in the nucleus accumbens, which was associated with an increase in the enzyme activity.
Gene_expression (expression) of tPA in nucleus accumbens associated with nucleus accumbens and morphine
16) Confidence 0.68 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.25 Pain Relevance 0.71
The defects of morphine-induced hyperlocomotion as well as methamphetamine-induced locomotor sensitization in tPA-/- mice were reversed by microinjection of exogenous tPA or plasmin into the nucleus accumbens.
Gene_expression (microinjection) of tPA in nucleus accumbens associated with nucleus accumbens and morphine
17) Confidence 0.68 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.21 Pain Relevance 0.72
A DNA microarray screening revealed that the expression levels of tissue plasminogen activator (tPA) mRNA in the nucleus accumbens of morphine- or methamphetamine-dependent rats were significantly increased compared with those in control animals.
Gene_expression (expression) of tPA in nucleus accumbens associated with nucleus accumbens and morphine
18) Confidence 0.68 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15684570 Disease Relevance 0.25 Pain Relevance 0.44
To explore the role of tPA in this disease as a model for MS, we have examined the EAE course and expression of histopathological markers in mice lacking tPA (tPA(-/-)).
Spec (examined) Gene_expression (expression) of tPA associated with multiple sclerosis and disease
19) Confidence 0.68 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12486171 Disease Relevance 1.57 Pain Relevance 0.51
In brain, tissue plasminogen activator (tPA) expression in astrocytes is the primary source of plasminogen activator and PAI-1 is the dominant inhibitor of tPA [21].
Gene_expression (expression) of tissue plasminogen activator in astrocytes
20) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.45 Pain Relevance 0.16

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