INT82932

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 5.75
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
embryos 1
hinge 1
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 78 99.80 Very High Very High Very High
adenocard 71 99.68 Very High Very High Very High
Pain 12 99.28 Very High Very High Very High
Catecholamine 1 94.72 High High
antagonist 29 89.16 High High
cytokine 5 85.44 High High
Potency 30 84.96 Quite High
withdrawal 28 84.16 Quite High
Inflammation 14 83.88 Quite High
Neuropeptide 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Disease 37 100.00 Very High Very High Very High
Sickle Cell Anemia 6 99.44 Very High Very High Very High
Death 19 98.36 Very High Very High Very High
Reprotox - General 1 199 96.08 Very High Very High Very High
Repression 8 96.04 Very High Very High Very High
Diabetes Mellitus 55 90.96 High High
Congenital Anomalies 10 90.48 High High
Cancer 147 87.52 High High
Metastasis 14 85.52 High High
Breast Cancer 33 85.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We describe a delayed hemolytic transfusion reaction (DHTR) presenting as a painful crisis in a patient with SCA.
Transcription (describe) of DHTR associated with sickle cell anemia and pain
1) Confidence 0.67 Published 1999 Journal Sao Paulo Med J Section Abstract Doc Link 10413970 Disease Relevance 0.66 Pain Relevance 0.23
Transcriptional activity of the androgen receptor, which was inhibited in the presence of bicalutamide, was then turned on.


Transcription (activity) of androgen receptor
2) Confidence 0.52 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.30 Pain Relevance 0.24
The effect of OCM on transcriptional activity of the AR was inhibited by an antiandrogen.
Transcription (activity) of AR
3) Confidence 0.48 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15014041 Disease Relevance 0.06 Pain Relevance 0
RRME treatment also decreased transcription of AR regulated genes and also reduced histone H3 and AR acetylation in the promoters of prostate-specific antigen (PSA) and beta-2-microglobulin (B2M).
Transcription (transcription) of AR
4) Confidence 0.41 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18562138 Disease Relevance 0.25 Pain Relevance 0
Transfection of AR-siRNA in LNCaP cells strongly inhibits the androgen-induced transcription of Prostate Specific Antigen (PSA), a prototypic AR-target gene (Figure 1B).
Transcription (transcription) of AR
5) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.63 Pain Relevance 0.04
Interestingly, NPAF increased the mRNA levels of beta2- and beta3-adrenergic receptors (AR), and to a lesser extent those of beta1-ARs.
Transcription (levels) of AR
6) Confidence 0.38 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12149260 Disease Relevance 0.29 Pain Relevance 0.30
In contrast to the lack of any impact by decursin or DA on the AR mRNA level in LNCaP cells [26,27], however, a sharp and rapid downregulation of ER?
Transcription (level) of AR
7) Confidence 0.30 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.38 Pain Relevance 0.06
Transcriptional activity of AR
Transcription (activity) of AR
8) Confidence 0.24 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2956710 Disease Relevance 0.99 Pain Relevance 0
A fragment of the protein product of FLNA negatively regulates transcription by AR through a physical interaction with the hinge region [110].
Transcription (transcription) of AR in hinge
9) Confidence 0.23 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2956710 Disease Relevance 0.27 Pain Relevance 0
Principally as a result of the difficulty in identifying potent and selective agonists, the A2B AR is the least extensively characterised of the adenosine receptors family.
Transcription (characterised) of AR associated with adenocard and agonist
10) Confidence 0.14 Published 2008 Journal Purinergic Signal Section Abstract Doc Link PMC2583210 Disease Relevance 0.14 Pain Relevance 0.36
AR mRNA and protein levels were reduced (Figures 2, 3).
Transcription (levels) of AR
11) Confidence 0.09 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174398 Disease Relevance 0.17 Pain Relevance 0
In the present study, however, we found no significant changes of mRNA levels of AR and GAPDH in the MD embryos, as noted previously with regard to the GAPDH expression (33), a difference we are unable to explain.
Transcription (levels) of AR in embryos
12) Confidence 0.05 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.53 Pain Relevance 0.03
The androgen receptor functions as a steroid-hormone activated transcription factor [11].
Transcription (transcription) of androgen receptor
13) Confidence 0.04 Published 2007 Journal Virol J Section Body Doc Link PMC2042503 Disease Relevance 0.67 Pain Relevance 0.08
It is worth noting that dHDAC6 did not suppress transcription of eGFP alone at two different insertion sites or of a polyglutamine disease gene (androgen receptor with 52 or 120 CAG repeats) in Drosophila [30], suggesting that the HDAC-mediated transcriptional repression we observe may be a CGG repeat-specific event.
Transcription (transcription) of androgen receptor associated with repression and disease
14) Confidence 0.01 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC3000359 Disease Relevance 0.41 Pain Relevance 0

General Comments

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