INT82966

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 9.91
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp)
Anatomy Link Frequency
plaque 2
mononuclear cells 2
joints 1
CII 1
vascular endothelium 1
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
cva 16 98.68 Very High Very High Very High
Angina 26 98.48 Very High Very High Very High
Pain 3 93.16 High High
Arthritis 17 91.68 High High
Inflammation 86 90.96 High High
Inflammatory marker 42 82.00 Quite High
rheumatoid arthritis 76 75.00 Quite High
alcohol 4 65.52 Quite High
ischemia 15 46.12 Quite Low
antagonist 1 40.76 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 6 100.00 Very High Very High Very High
Cv General 3 Under Development 34 98.68 Very High Very High Very High
Myocardial Infarction 74 97.24 Very High Very High Very High
Atherosclerosis 12 97.08 Very High Very High Very High
Stroke 121 96.00 Very High Very High Very High
Death 44 96.00 Very High Very High Very High
Coronary Artery Disease 34 95.64 Very High Very High Very High
Cerebrovascular Disease 1 95.16 Very High Very High Very High
Uveitis 3 94.44 High High
Cancer 8 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
C-reactive protein (CRP) mRNA was detected in coronary plaque.
Transcription (detected) of C-reactive protein in plaque
1) Confidence 0.70 Published 2004 Journal Am. J. Cardiol. Section Abstract Doc Link 14996590 Disease Relevance 0.27 Pain Relevance 0.40
C-reactive protein (CRP) mRNA was detected in coronary plaque.
Transcription (detected) of CRP in plaque
2) Confidence 0.70 Published 2004 Journal Am. J. Cardiol. Section Abstract Doc Link 14996590 Disease Relevance 0.27 Pain Relevance 0.40
Model calibration was adequate after the addition of IL-6, white cell count, and CRP.
Transcription (addition) of CRP
3) Confidence 0.62 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 0.53 Pain Relevance 0.04
The results indicated that puerarin inhibited the expression of the protein and mRNA levels of CRP in LPS-induced peripheral blood mononuclear cells.
Transcription (levels) of CRP in mononuclear cells
4) Confidence 0.59 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20346059 Disease Relevance 0.40 Pain Relevance 0.37
CONCLUSIONS: Our data suggest that a common daily dose of simvastatin, especially 40 mg, is an effective 2-week therapy for patients with hypercholesterolemia, and benefit to the vascular endothelium can be derived quickly by reduction of CRP levels.


Transcription (levels) of CRP in vascular endothelium
5) Confidence 0.52 Published 2003 Journal Clin Cardiol Section Body Doc Link 14579918 Disease Relevance 0 Pain Relevance 0
CRP levels after 12, 24, and 72 hours were also significantly different to the initial values for patients with stable CAD (P < 0.01).
Transcription (levels) of CRP associated with coronary artery disease
6) Confidence 0.50 Published 2002 Journal Jpn Heart J Section Abstract Doc Link 12558125 Disease Relevance 1.56 Pain Relevance 0.36
The protein and mRNA levels of CRP were determined in lipopolysaccharide (LPS)-induced peripheral blood mononuclear cells of patients with unstable angina pectoris.
Transcription (levels) of CRP in mononuclear cells associated with angina
7) Confidence 0.44 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20346059 Disease Relevance 0.45 Pain Relevance 0.36
The best cut-off serum levels for PCT and CRP, identified using the Youden's Index, were 0.6 ng/ml and 60 mg/l, respectively.
Transcription (levels) of CRP
8) Confidence 0.40 Published 2004 Journal Crit Care Section Abstract Doc Link PMC420058 Disease Relevance 0.72 Pain Relevance 0
Concerning clinical parameters, a significant improvement (p < 0.05) of the number of swollen and tender joints was observed after 12 months, as well as a reduction of CRP levels.
Transcription (levels) of CRP in joints
9) Confidence 0.34 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415634 Disease Relevance 0.47 Pain Relevance 0.10
In univariate Cox analyses, a high level of tissue-plasminogen activator (t-PA), apolipoprotein CII, C-reactive protein (CRP), and a low level of high-density lipoprotein-cholesterol (HDL-C) was each associated with a significant increase in the risk of future cardiac events.
Spec (analyses) Transcription (level) of CRP in CII associated with disorder of lipid metabolism
10) Confidence 0.29 Published 1999 Journal Jpn. Circ. J. Section Abstract Doc Link 10614844 Disease Relevance 1.00 Pain Relevance 0.24
In another substudy of the COMMA trial, it was shown that higher CRP and interleukin-6 (IL-6) levels at baseline, 24 hours, and 72 hours were associated with increased death, and that elevated CRP, IL-6, and tumor necrosis factor-?
Transcription (higher) of CRP associated with necrosis, cancer and death
11) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.72 Pain Relevance 0
CRP levels were similar in the high, medium and low MBL2 genotype group (Table 3), even after stratification for remission status (P > 0.10; Figure 2).
Transcription (levels) of CRP
12) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.47 Pain Relevance 0.05
Median (IQR) levels for IL-6, CRP, and fibrinogen were 1.12 pg/mL (0.72-1.74), 2.00 mg/L (0.82-4.59), and 340 mg/dL (296-391), respectively.
Transcription (levels) of CRP
13) Confidence 0.18 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2996373 Disease Relevance 0.69 Pain Relevance 0.06
We also collected data on high sensitive C-reactive protein (hsCRP) concentrations, which were categorized as high and low according to an established cut-off (?
Transcription (sensitive) of hsCRP
14) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901328 Disease Relevance 1.88 Pain Relevance 0.19
Furthermore, each of the evaluation items, with the exception of ESR and CRP, used to calculate DAS28-ESR, CDAI and SDAI progressively improved during the TCZ treatment.
Neg (exception) Transcription (exception) of CRP
15) Confidence 0.08 Published 2010 Journal Mod Rheumatol Section Body Doc Link PMC2999727 Disease Relevance 0.40 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox