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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.88
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp)
Anatomy Link Frequency
joints 2
mononuclear cells 2
vascular endothelium 2
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 4 92.24 High High
Inflammation 3 77.52 Quite High
rheumatoid arthritis 1 75.00 Quite High
Pain 1 62.92 Quite High
Disease Link Frequency Relevance Heat
Hirsutism 2 92.40 High High
Cv General 3 Under Development 3 92.24 High High
Disease 1 91.60 High High
INFLAMMATION 3 77.52 Quite High
Rheumatoid Arthritis 3 75.00 Quite High
Stable Angina Pectoris 1 75.00 Quite High
Pain 1 62.92 Quite High
Hyperlipidemia 2 50.00 Quite Low
Coronary Artery Disease 1 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicated that puerarin inhibited the expression of the protein and mRNA levels of CRP in LPS-induced peripheral blood mononuclear cells.
Negative_regulation (inhibited) of Transcription (levels) of CRP in mononuclear cells
1) Confidence 0.49 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20346059 Disease Relevance 0.41 Pain Relevance 0.37
CONCLUSIONS: Our data suggest that a common daily dose of simvastatin, especially 40 mg, is an effective 2-week therapy for patients with hypercholesterolemia, and benefit to the vascular endothelium can be derived quickly by reduction of CRP levels.

Negative_regulation (reduction) of Transcription (levels) of CRP in vascular endothelium
2) Confidence 0.42 Published 2003 Journal Clin Cardiol Section Body Doc Link 14579918 Disease Relevance 0 Pain Relevance 0
Concerning clinical parameters, a significant improvement (p < 0.05) of the number of swollen and tender joints was observed after 12 months, as well as a reduction of CRP levels.
Negative_regulation (reduction) of Transcription (levels) of CRP in joints
3) Confidence 0.27 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415634 Disease Relevance 0.47 Pain Relevance 0.10

General Comments

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