INT82984

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 27
Total Number 33
Disease Relevance 3.93
Pain Relevance 11.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cartpt) extracellular region (Cartpt)
Anatomy Link Frequency
pituitary 4
Purkinje cell 3
brain 2
cerebellum 2
arcuate nucleus 2
Cartpt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 574 100.00 Very High Very High Very High
Neurotransmitter 51 100.00 Very High Very High Very High
antinociception 1 99.96 Very High Very High Very High
substance P 88 99.62 Very High Very High Very High
gABA 91 99.32 Very High Very High Very High
addiction 17 99.18 Very High Very High Very High
Enkephalin 15 99.18 Very High Very High Very High
Glutamate 73 98.92 Very High Very High Very High
Calcitonin gene-related peptide 97 98.68 Very High Very High Very High
Pain 20 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 33 100.00 Very High Very High Very High
Ganglion Cysts 9 99.70 Very High Very High Very High
Pain 13 98.60 Very High Very High Very High
Drug Dependence 7 97.64 Very High Very High Very High
Stress 261 97.28 Very High Very High Very High
Nociception 9 93.48 High High
Body Weight 10 91.52 High High
Nervous System Injury 4 89.28 High High
Targeted Disruption 111 87.28 High High
Aging 5 85.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have provided several lines of evidence that CART peptides are expressed by climbing fibres: (1) There is CART peptide immunofluorescence in the inferior olivary complex, the source of climbing fibres. (2) No cerebellar cell bodies were labelled by the CART peptide antibody. (3) The developmental profile of CART peptide expression was consistent with climbing fibre development and finally (4) triple antibody labelling revealed co-expression of CART peptides with VGluT2 (the glutamate transporter at climbing fibre synapses) at boutons innervating calbindin D-28K labelled proximal Purkinje cell dendrites.
Gene_expression (expression) of CART peptide in Purkinje cell associated with glutamate
1) Confidence 0.78 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18078990 Disease Relevance 0.13 Pain Relevance 0.18
We have further investigated the expression of CART peptides in rat cerebellum, using multiple fluorescent antibodies.
Spec (investigated) Gene_expression (expression) of CART in cerebellum
2) Confidence 0.78 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18078990 Disease Relevance 0.20 Pain Relevance 0.18
Expression of cocaine- and amphetamine-regulated transcript (CART) peptides at climbing fibre-Purkinje cell synapses in the rat vestibular cerebellum.
Gene_expression (Expression) of CART in cerebellum associated with cocaine
3) Confidence 0.78 Published 2008 Journal Neuropeptides Section Title Doc Link 18078990 Disease Relevance 0.17 Pain Relevance 0.18
We have provided several lines of evidence that CART peptides are expressed by climbing fibres: (1) There is CART peptide immunofluorescence in the inferior olivary complex, the source of climbing fibres. (2) No cerebellar cell bodies were labelled by the CART peptide antibody. (3) The developmental profile of CART peptide expression was consistent with climbing fibre development and finally (4) triple antibody labelling revealed co-expression of CART peptides with VGluT2 (the glutamate transporter at climbing fibre synapses) at boutons innervating calbindin D-28K labelled proximal Purkinje cell dendrites.
Gene_expression (expressed) of CART in Purkinje cell associated with glutamate
4) Confidence 0.78 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18078990 Disease Relevance 0.15 Pain Relevance 0.19
Almost all (97.9%) randomly selected calcitonin gene-related peptide (CGRP)-immunoreactive terminals were substance P (SP)-positive (+) and CART was detected in approximately half (48.6%) of them.
Gene_expression (detected) of CART associated with substance p and calcitonin gene-related peptide
5) Confidence 0.77 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19490082 Disease Relevance 0.29 Pain Relevance 0.69
To establish whether or not Cart can be consider as a valuable marker of addiction we performed a comparative study of the expression of Cart and Fos genes by several drugs of abuse.
Gene_expression (expression) of Cart associated with addiction
6) Confidence 0.75 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12821175 Disease Relevance 0 Pain Relevance 0.37
CART peptide is a peptidergic neurotransmitter that is expressed in brain regions involved in critical biological processes such as feeding and stress, and in areas associated with drug reward and abuse including the dopamine-rich nucleus accumbens (NAcc), which can be considered part of the basal ganglia.
Gene_expression (expressed) of CART in NAcc associated with stress, nucleus accumbens, dopamine and neurotransmitter
7) Confidence 0.68 Published 2006 Journal Neuropeptides Section Abstract Doc Link 17064765 Disease Relevance 0.10 Pain Relevance 0.40
CART produces antinociception in the formalin test in both phases.
Gene_expression (produces) of CART associated with antinociception
8) Confidence 0.68 Published 2003 Journal Brain Res. Section Abstract Doc Link 12914986 Disease Relevance 0.09 Pain Relevance 0.41
Analysis of VGluT2 and CART peptide labelling in more detail showed that not all climbing fibres in the vestibular cerebellum expressed CART peptides but those fibres which did express CART peptides were immunofluorescent at all Purkinje cell synapses.
Neg (not) Gene_expression (expressed) of CART in synapses
9) Confidence 0.68 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18078990 Disease Relevance 0 Pain Relevance 0.08
Mesolimbic gender differences in peptide CART mRNA expression: effects of cocaine.
Gene_expression (expression) of CART associated with enkephalin and cocaine
10) Confidence 0.68 Published 1999 Journal Neuroreport Section Title Doc Link 10599860 Disease Relevance 0 Pain Relevance 0.32
A gender difference was noted in the accumbens shell during basal conditions; male rats expressed higher levels of CART mRNA than both female groups.
Gene_expression (expressed) of CART in shell
11) Confidence 0.68 Published 1999 Journal Neuroreport Section Abstract Doc Link 10599860 Disease Relevance 0 Pain Relevance 0.22
We analyzed the CART mRNA expression in mesolimbic brain areas of male and ovariectomized 17beta-estradiol- (30 microg) and vehicle-treated female rats.
Spec (analyzed) Gene_expression (expression) of CART in brain
12) Confidence 0.68 Published 1999 Journal Neuroreport Section Abstract Doc Link 10599860 Disease Relevance 0 Pain Relevance 0.19
Using tract tracing, multiple immunofluorescent labelling and electronmicroscopy we determined the proportion of peptidergic primary afferents expressing CART, looked for evidence for coexistence of CART with galanin in these afferents in lamina I and examined their targets.
Gene_expression (expressing) of CART in lamina
13) Confidence 0.67 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19490082 Disease Relevance 0.27 Pain Relevance 0.63
We have provided several lines of evidence that CART peptides are expressed by climbing fibres: (1) There is CART peptide immunofluorescence in the inferior olivary complex, the source of climbing fibres. (2) No cerebellar cell bodies were labelled by the CART peptide antibody. (3) The developmental profile of CART peptide expression was consistent with climbing fibre development and finally (4) triple antibody labelling revealed co-expression of CART peptides with VGluT2 (the glutamate transporter at climbing fibre synapses) at boutons innervating calbindin D-28K labelled proximal Purkinje cell dendrites.
Gene_expression (expression) of CART in Purkinje cell associated with glutamate
14) Confidence 0.60 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18078990 Disease Relevance 0.12 Pain Relevance 0.18
Subsequent studies have identified that CART is expressed in a number of regions known to be involved in reward and reinforcement, including the ventral tegmental area (VTA), nucleus accumbens (NAC), amygdala and hypothalamus [2], [3].
Gene_expression (expressed) of CART in amygdala associated with nucleus accumbens, ventral tegmentum and amygdala
15) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944892 Disease Relevance 0.08 Pain Relevance 0.40
Similarly, the two animals that received misplaced CART injections (M?
Gene_expression (injections) of CART
16) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944892 Disease Relevance 0 Pain Relevance 0.71
Indeed, electrophysiological studies indicate that CART can produce inhibitory post-synaptic effects when applied to brain slices [36].
Gene_expression (produce) of CART in brain
17) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944892 Disease Relevance 0 Pain Relevance 0.97
6.47) and 2.5 µg CART (M?
Gene_expression (2.5) of CART
18) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944892 Disease Relevance 0 Pain Relevance 0.82
We have noted differences between male and female rats in the mesolimbic mRNA expression of CART that might be relevant for gender differences apparent in drug abuse.
Gene_expression (expression) of CART associated with drug abuse
19) Confidence 0.55 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415667 Disease Relevance 0.17 Pain Relevance 0.92
Analysis of VGluT2 and CART peptide labelling in more detail showed that not all climbing fibres in the vestibular cerebellum expressed CART peptides but those fibres which did express CART peptides were immunofluorescent at all Purkinje cell synapses.
Gene_expression (express) of CART in synapses
20) Confidence 0.53 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18078990 Disease Relevance 0 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox