INT82988

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Context Info
Confidence 0.38
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DRD3) signal transducer activity (DRD3)
Anatomy Link Frequency
nucleus accumbens 2
DRD3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 12 99.70 Very High Very High Very High
Kappa opioid receptor 3 98.72 Very High Very High Very High
Nucleus accumbens 3 97.78 Very High Very High Very High
Dopamine 7 80.84 Quite High
addiction 2 78.00 Quite High
amygdala 1 75.60 Quite High
Endogenous opioid 1 75.44 Quite High
Opioid 1 70.32 Quite High
Disease Link Frequency Relevance Heat
Overdose 5 98.64 Very High Very High Very High
Delirium 1 81.84 Quite High
Cocaine Dependence 2 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D3 receptor/cyclophilin mRNA ratios in the nucleus accumbens were increased sixfold in cocaine-overdose victims over control values, suggesting that cocaine exposure also affects the expression of D3 receptor mRNA.
Regulation (affects) of Transcription (expression) of D3 receptor mRNA in nucleus accumbens associated with nucleus accumbens, overdose and cocaine
1) Confidence 0.38 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415668 Disease Relevance 0.59 Pain Relevance 1.26

General Comments

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