INT82992

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.12
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DRD3) signal transducer activity (DRD3)
Anatomy Link Frequency
nucleus accumbens 1
DRD3 (Homo sapiens)
Pain Link Frequency Relevance Heat
dopamine receptor 20 100.00 Very High Very High Very High
cocaine 12 99.46 Very High Very High Very High
Kappa opioid receptor 3 98.72 Very High Very High Very High
Dopamine 101 98.16 Very High Very High Very High
Nucleus accumbens 7 97.54 Very High Very High Very High
Nicotine 184 86.04 High High
positron emission tomography 8 82.88 Quite High
addiction 72 77.52 Quite High
amygdala 1 75.60 Quite High
Endogenous opioid 1 74.96 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 344 99.64 Very High Very High Very High
Overdose 5 98.40 Very High Very High Very High
Delirium 1 81.84 Quite High
Cocaine Dependence 2 77.52 Quite High
Depression 20 5.00 Very Low Very Low Very Low
Alcohol Addiction 20 5.00 Very Low Very Low Very Low
Neurosis 14 5.00 Very Low Very Low Very Low
Drug Dependence 8 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 8 5.00 Very Low Very Low Very Low
Substance Withdrawal Syndrome 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D3 receptor/cyclophilin mRNA ratios in the nucleus accumbens were increased sixfold in cocaine-overdose victims over control values, suggesting that cocaine exposure also affects the expression of D3 receptor mRNA.
Gene_expression (expression) of D3 receptor mRNA in nucleus accumbens associated with nucleus accumbens, overdose and cocaine
1) Confidence 0.50 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415668 Disease Relevance 0.59 Pain Relevance 1.25
Furthermore, smoking may create a vicious cycle of reward and deficiency; a recent study found that smoking seems to inhibit dopamine receptor D3 mRNA expression, thereby diminishing the rewarding effect of dopamine, leading to a reward deficiency state and creating motivation for continued smoking [37].
Gene_expression (expression) of dopamine receptor D3 mRNA associated with dopamine, nicotine addiction and dopamine receptor
2) Confidence 0.34 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2669467 Disease Relevance 0.77 Pain Relevance 0.81
Furthermore, smoking may create a vicious cycle of reward and deficiency; a recent study found that smoking seems to inhibit dopamine receptor D3 mRNA expression, thereby diminishing the rewarding effect of dopamine, leading to a reward deficiency state and creating motivation for continued smoking [37].
Gene_expression (expression) of dopamine receptor D3 mRNA associated with dopamine, nicotine addiction and dopamine receptor
3) Confidence 0.34 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2671538 Disease Relevance 0.77 Pain Relevance 0.81

General Comments

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