INT82996

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Context Info
Confidence 0.51
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.60
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PKLR) small molecule metabolic process (PKLR) carbohydrate metabolic process (PKLR)
Anatomy Link Frequency
pancreas 1
PKLR (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 1 30.48 Quite Low
Central nervous system 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 6 93.60 High High
Congenital Anomalies 2 90.72 High High
Apoptosis 10 89.52 High High
Phlebotomus Fever 4 78.92 Quite High
Pancreatic Cancer 1 76.40 Quite High
Death 2 62.08 Quite High
Infection 130 52.56 Quite High
Coccidioides Infection 112 50.00 Quite Low
Pancreatitis 2 39.36 Quite Low
Sprains And Strains 44 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study the mRNA expression of CA isozymes in human pancreas, reverse transcriptase-polymerase chain reaction (RT-PCR)-Southern blot analysis and cDNA sequencing following RT-PCR were employed.
Transcription (expression) of isozymes in pancreas
1) Confidence 0.51 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415846 Disease Relevance 0.08 Pain Relevance 0
Altogether, it appears that NSs has multiple functions to counteract the host cell interferon response, either at the transcriptional or at the translational levels by degrading PKR, which in turn facilitates translation of the viral products [126].


Transcription (transcriptional) of PKR
2) Confidence 0.09 Published 2010 Journal Veterinary Research Section Body Doc Link PMC2896810 Disease Relevance 0.28 Pain Relevance 0
Very recently, a novel function of NSs was described simultaneously by Ikegami et al. [127, 128] and Habjan et al. [109]: NSs promotes post transcriptional downregulation of dsRNA-dependent protein kinase (PKR) and therefore prevents phosphorylation of eIF2?
Transcription (transcriptional) of PKR
3) Confidence 0.09 Published 2010 Journal Veterinary Research Section Body Doc Link PMC2896810 Disease Relevance 0.24 Pain Relevance 0

General Comments

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