INT83006

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 59
Total Number 60
Disease Relevance 54.46
Pain Relevance 7.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AGTR1) signal transducer activity (AGTR1)
Anatomy Link Frequency
plasma 2
fibroblasts 2
carotid body 2
pancreas 2
aorta 1
AGTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 257 100.00 Very High Very High Very High
Inflammation 2536 99.96 Very High Very High Very High
Calcium channel 15 98.80 Very High Very High Very High
fibrosis 180 97.88 Very High Very High Very High
beta blocker 9 97.66 Very High Very High Very High
cytokine 311 97.64 Very High Very High Very High
bradykinin 29 97.48 Very High Very High Very High
medulla 37 97.20 Very High Very High Very High
chemokine 190 97.08 Very High Very High Very High
Inflammatory response 80 94.84 High High
Disease Link Frequency Relevance Heat
Pre-eclampsia 66 100.00 Very High Very High Very High
INFLAMMATION 2738 99.96 Very High Very High Very High
Injury 581 99.92 Very High Very High Very High
Breast Cancer 125 99.84 Very High Very High Very High
Carcinoma 110 99.80 Very High Very High Very High
Cancer 3440 99.76 Very High Very High Very High
Diabetic Retinopathy 235 99.76 Very High Very High Very High
Hypoxia 594 99.68 Very High Very High Very High
Atherosclerosis 55 99.66 Very High Very High Very High
Metastasis 259 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both AT1aR and TRPV4 were expressed at the cell surface and exhibited clear colocalization indicating a potential interaction (Fig. 1E).
Gene_expression (expressed) of AT1aR
1) Confidence 0.75 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
These cells, isolated from rat aorta, endogenously express AT1aR, TRPV4, and ?
Gene_expression (express) of AT1aR in aorta
2) Confidence 0.75 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
As rVSMCs express very low levels (20 fmol/mg) of AT1aR, which is insufficient for coimmunoprecipitation, we transfected these cells with HA-AT1aR to probe a direct interaction between AT1aR and TRPV4.
Gene_expression (express) of AT1aR
3) Confidence 0.75 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
Indeed it is anticipated that prolonged expression of AT1 combined with a lack of AT2 expression results in sustained chronic inflammation and fibrosis.
Gene_expression (expression) of AT1 associated with fibrosis and inflammation
4) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.88 Pain Relevance 0.39
Hypoxia has been demonstrated to induce the expression of both AT1b (AT1a and AT1b are subsets of AT1) and AT2 receptors in the rat carotid body and pancreas [39,40].
Gene_expression (expression) of AT1b in pancreas associated with hypoxia
5) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.11 Pain Relevance 0.05
In this case, in situ carcinoma has over-expressed AT1 receptors in addition to expressing proteins for yet more AT1.
Gene_expression (expressing) of AT1 associated with carcinoma
6) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.61 Pain Relevance 0.04
Since hypoxia counts for the expression of AT1b, the speculation that the AT1a subtype is induced by oxidative stress is tempting, although a review of literature appears absent in this regard and further investigation is required to confirm this hypothesis.
Gene_expression (expression) of AT1b associated with stress and hypoxia
7) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.49 Pain Relevance 0.06
Significant evidence has been shown that AT1 receptors are upregulated during disease and that AT2 receptor expression follows behind AT1 expression during injury and healing.
Gene_expression (expression) of AT1 associated with injury and disease
8) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.91 Pain Relevance 0.39
AT1 receptors are expressed in various parts of the body and are associated with their respective functions, such as blood vessels, adrenal cortex, liver, kidney and brain, while AT2 receptors are highest in fetal mesenchymal tissue, adrenal medulla, uterus and ovarian follicles [13].
Gene_expression (expressed) of AT1 in liver associated with medulla
9) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.12 Pain Relevance 0.10
The expression of AT1 and AT2 receptors on fibroblasts present in cardiac fibrosis is investigated [79].
Spec (investigated) Gene_expression (expression) of AT1 in fibroblasts associated with fibrosis and cardiovascular disorder under development
10) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.19 Pain Relevance 0.31
Hypoxia has been shown to strongly induce the expression of AT1b but not AT1a.
Gene_expression (expression) of AT1b associated with hypoxia
11) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.02 Pain Relevance 0.04
The evidence relating to over-expression of AT1 with cancer progression is compelling.
Gene_expression (over) of AT1 associated with cancer
12) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.77 Pain Relevance 0.07
Stresses and cell damage on the growing tumour boundary could potentially be causing the expression of AT1.
Gene_expression (expression) of AT1 associated with stress and cancer
13) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.80 Pain Relevance 0.04
The expression of AT1 and AT2 receptors has been studied during the development and regression of hypoxic pulmonary hypertension [41].
Gene_expression (expression) of AT1 associated with hypoxia and hypertension
14) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.02 Pain Relevance 0.04
In this case, in situ carcinoma has over-expressed AT1 receptors in addition to expressing proteins for yet more AT1.
Gene_expression (expressed) of AT1 associated with carcinoma
15) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.67 Pain Relevance 0.04
The role of AT1 post-metastasis, given the observation that AT1 protein expression ceases, as demonstrated in the breast cancer study, requires further investigation [35].
Gene_expression (expression) of AT1 associated with breast cancer and metastasis
16) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.81 Pain Relevance 0.44
Most, if not all, solid tumours utilise inflammation processes, which, through the over-expression and activation of AT1 and the subsequent expression of a number of inflammatory cytokines and chemokines, allow for tumour protection from the immune system through immunosuppression, as well as tumour progression and metastasis.
Gene_expression (expression) of AT1 in immune system associated with chemokine, inflammation, cancer, solid tumor, metastasis and cytokine
17) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.37 Pain Relevance 0.48
Evidence that appears to support this view can be found in a study of AT1 expression in breast cancers [35].
Gene_expression (expression) of AT1 associated with breast cancer
18) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.68 Pain Relevance 0.04
Strong evidence suggests that tumour cells over-express AT1 receptors and compelling evidence has been presented on the implications of AT1 in cancer progression.
Gene_expression (express) of AT1 associated with cancer
19) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.02 Pain Relevance 0.26
Is it evolution that causes over expression of AT1?
Gene_expression (expression) of AT1
20) Confidence 0.73 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.50 Pain Relevance 0.03

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