INT83014

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Context Info
Confidence 0.48
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 5.57
Pain Relevance 5.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora2a) plasma membrane (Adora2a) enzyme binding (Adora2a)
signal transducer activity (Adora2a)
Anatomy Link Frequency
neuronal 1
spinal 1
projection neurons 1
brain 1
brainstem 1
Adora2a (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 262 100.00 Very High Very High Very High
antagonist 98 100.00 Very High Very High Very High
Dopamine 79 100.00 Very High Very High Very High
Cannabinoid 2 99.82 Very High Very High Very High
Inflammation 155 99.40 Very High Very High Very High
methotrexate 120 99.20 Very High Very High Very High
addiction 38 99.12 Very High Very High Very High
projection neuron 2 98.64 Very High Very High Very High
agonist 46 98.44 Very High Very High Very High
Arthritis 6 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 144 99.40 Very High Very High Very High
Rheumatoid Arthritis 35 99.00 Very High Very High Very High
Hypotension 9 98.96 Very High Very High Very High
Psychosis 48 98.68 Very High Very High Very High
Hypoxia 66 98.50 Very High Very High Very High
Arthritis 5 98.28 Very High Very High Very High
Targeted Disruption 53 97.72 Very High Very High Very High
Disease 40 95.12 Very High Very High Very High
Neuropathic Pain 1 94.44 High High
Nervous System Injury 1 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was important to establish whether inflamed and hypoxic lung tissues are protected by enhanced adenosine formation and subsequent A2AR engagement or by an anti-inflammatory role of a yet-to-be-uncovered hypoxia ?
A2AR Binding (engagement) of in lung associated with adenocard, inflammation and hypoxia
1) Confidence 0.48 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 1.22 Pain Relevance 0.29
Both purinergic and cannabinoid systems interact with dopamine neurotransmission (through A2A and CB1 receptors, respectively).
A2A Binding (interact) of associated with dopamine and cannabinoid
2) Confidence 0.38 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15450100 Disease Relevance 0.21 Pain Relevance 0.57
It has been proposed that adenosine binding to A2AR lowers the affinity of dopamine for D2R, thus modulating the function of this receptor.
A2AR Binding (binding) of associated with dopamine and adenocard
3) Confidence 0.35 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10908627 Disease Relevance 0.39 Pain Relevance 0.41
The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population

Background

adenosine A2A receptor Binding (associated) of associated with addiction, adenocard and psychosis
4) Confidence 0.31 Published 2010 Journal Behav Brain Funct Section Title Doc Link PMC2939586 Disease Relevance 0.54 Pain Relevance 0.39
These results indicate that agents which interact with adenosine A2A receptors directly or promote adenosine release at inflamed sites may be useful for the treatment of inflammatory conditions, whereas occupancy of other adenosine receptors may be involved in suppression of inflammation in a site-specific fashion.


A2A Binding (interact) of associated with adenocard and inflammation
5) Confidence 0.30 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.06 Pain Relevance 0.92
Specifically, associations were observed between several ADORA2a SNPs and GI AEs on MTX.
ADORA2a Binding (associations) of associated with methotrexate
6) Confidence 0.27 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.25 Pain Relevance 0.22
Five SNPs within ADORA2a were associated with stopping MTX for AEs (OR 2.1–3.07, P < 0.05 for all).
ADORA2a Binding (associated) of
7) Confidence 0.24 Published 2008 Journal Rheumatology (Oxford, England) Section Abstract Doc Link PMC2468887 Disease Relevance 0.32 Pain Relevance 0.07
A strong antagonistic interaction between A2A and D2 receptors in the striatal projection neurons can explain the cross-sensitization between caffeine, or an A2A antagonist, and a D2 dopamine agonist.
A2A Binding (interaction) of in projection neurons associated with dopamine, antagonist, agonist and projection neuron
8) Confidence 0.21 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2843608 Disease Relevance 0 Pain Relevance 0.60
Evidence demonstrates that caffeine and selective adenosine A2A antagonists interact with the neuronal systems involved in drug reinforcement, locomotor sensitization, and therapeutic effect in Parkinson's disease (PD).
A2A Binding (interact) of in neuronal associated with adenocard, antagonist and disease
9) Confidence 0.21 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2843608 Disease Relevance 0.19 Pain Relevance 0.39
Interaction of angiotensin II and adenosine A1 and A2A receptor ligands on the writhing test in mice.
A2A receptor Binding (Interaction) of associated with adenocard
10) Confidence 0.15 Published 2002 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 11900765 Disease Relevance 0 Pain Relevance 0.68
In low doses, which are the most relevant to human use, caffeine effects are exerted by antagonizing brain adenosine A1 and A2A receptors with secondary effects on dopaminergic neurotransmission [1].
A2A Binding (antagonizing) of in brain associated with adenocard
11) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0.32 Pain Relevance 0.14
LNP 509, which binds to I1Rs (Ki = 5.10(-7) M) but roughly not to alpha 2-adrenoceptors (A2Rs) (Ki > 10(-5) M), causes hypotension when injected alone into the brainstem.
A2Rs Binding (binds) of in brainstem associated with medulla and hypotension
12) Confidence 0.02 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415925 Disease Relevance 0.63 Pain Relevance 0.12
Here we present the spinal NPYergic system from an immunohistochemical perspective based on recent studies using two specific antibodies recognizing the Y1- and Y2Rs, respectively, as well as on data from a study on a Y1R knock-out mouse.
Y2Rs Binding (recognizing) of in spinal associated with targeted disruption
13) Confidence 0.01 Published 2007 Journal Peptides Section Abstract Doc Link 17234301 Disease Relevance 0.45 Pain Relevance 0.52

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