INT83030

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.35
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INSR) endosome (INSR) plasma membrane (INSR)
nucleus (INSR) carbohydrate metabolic process (INSR)
Anatomy Link Frequency
platelet 2
INSR (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 3 99.84 Very High Very High Very High
addiction 1 87.28 High High
Opioid 1 86.88 High High
antidepressant 1 84.72 Quite High
antagonist 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 3 99.84 Very High Very High Very High
Suicidal Behaviour 2 96.48 Very High Very High Very High
Cancer 49 92.52 High High
Prostate Cancer 53 90.80 High High
Glioma 2 89.12 High High
Neurodegenerative Disease 1 88.40 High High
Opiate Addiction 1 87.28 High High
Metastasis 18 79.92 Quite High
Brain Disease 1 75.00 Quite High
Disease 18 60.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It can be activated upon engagement of growth factor receptors, such as EGFR, PDGFR, INSR or IGF1R, and in turn activate downstream PLC and PI3K signaling pathways [51], [52], [66].
Positive_regulation (activated) of INSR Binding (engagement) of
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.38 Pain Relevance 0
The density of platelet I1-IR ([125I]-p-iodoclonidine binding) is also increased in depression (135%).
Positive_regulation (increased) of IR Binding (binding) of in platelet associated with depression
2) Confidence 0.11 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415944 Disease Relevance 0.97 Pain Relevance 0.31

General Comments

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