INT83032

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Context Info
Confidence 0.55
First Reported 1999
Last Reported 2006
Negated 1
Speculated 2
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.20
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NISCH) plasma membrane (NISCH) cytoplasm (NISCH)
Anatomy Link Frequency
Brain 1
NISCH (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 14 97.72 Very High Very High Very High
Opioid 5 92.28 High High
addiction 5 92.00 High High
antidepressant 1 85.00 Quite High
mu opioid receptor 4 78.64 Quite High
depression 3 77.36 Quite High
narcan 8 65.84 Quite High
antagonist 2 38.16 Quite Low
Disease Link Frequency Relevance Heat
Disease 3 99.44 Very High Very High Very High
Glioma 2 96.24 Very High Very High Very High
Opiate Addiction 5 92.28 High High
Suicidal Behaviour 2 80.72 Quite High
Depression 3 77.36 Quite High
Brain Disease 1 75.00 Quite High
Neurodegenerative Disease 1 63.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study investigated the effects of agmatine action on imidazoline I1 receptor antisera-selected protein (IRAS), a candidate for imidazoline I1 receptor, on prolonged morphine-induced adaptations of calcium signal and long-lasting alterations in gene expression to further elucidate the role of IRAS in opioid dependence.
Spec (investigated) Regulation (effects) of IRAS associated with addiction, opioid and morphine
1) Confidence 0.55 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16962578 Disease Relevance 0.09 Pain Relevance 0.51
The present study investigated the effects of agmatine action on imidazoline I1 receptor antisera-selected protein (IRAS), a candidate for imidazoline I1 receptor, on prolonged morphine-induced adaptations of calcium signal and long-lasting alterations in gene expression to further elucidate the role of IRAS in opioid dependence.
Spec (investigated) Regulation (effects) of antisera-selected associated with addiction, opioid and morphine
2) Confidence 0.35 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16962578 Disease Relevance 0.09 Pain Relevance 0.48
Brain I2B-IR is not altered in Parkinson's disease.
Neg (not) Regulation (altered) of I2B-IR in Brain associated with disease
3) Confidence 0.17 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415944 Disease Relevance 1.01 Pain Relevance 0.24

General Comments

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