INT83033

Context Info Confidence 0.41 First Reported 1999 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.55 Pain Relevance 0.21

extracellular region (MEPE) proteinaceous extracellular matrix (MEPE)

Anatomy Link Frequency neural crest 1 MEPE (Homo sapiens)

Pain Link Frequency Relevance Heat antidepressant 1 77.00 depression 3 69.36 addiction 1 53.96 Opioid 1 53.56 cva 2 21.08 Pain 3 5.00 vincristine 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Cancer 33 100.00 Skin Cancer 11 99.46 Glioma 2 97.60 Disease 4 93.76 Congenital Anomalies 1 75.96 Brain Disease 1 75.00 Suicidal Behaviour 2 72.72 Chromosome Aberrations 1 70.40 Depression 3 69.36 Amputation 1 55.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The level of I2-IR in glial tumors is increased (two-fivefold) in parallel with the abundance of the related 29/30-kD IR protein (39%), whereas the level of 45-kD IR protein is decreased (39%).

Negative_regulation (decreased) of of 45 associated with glioma

1) Confidence 0.41 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415944 Disease Relevance 0.93 Pain Relevance 0.21

Both CCSTA and malignant melanoma are immunohistochemically positive for S-100 protein (a marker for tumors derived from neural crest) and HMB-45 (a marker identifying tumors associated with melanoma) [18] suggesting that these tumors have a close relationship.

Negative_regulation (positive) of HMB-45 in neural crest associated with cancer and skin cancer

2) Confidence 0.05 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1555585 Disease Relevance 1.62 Pain Relevance 0

General Comments

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