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Context Info
Confidence 0.41
First Reported 1999
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.55
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MEPE) proteinaceous extracellular matrix (MEPE)
Anatomy Link Frequency
neural crest 1
MEPE (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 1 77.00 Quite High
depression 3 69.36 Quite High
addiction 1 53.96 Quite High
Opioid 1 53.56 Quite High
cva 2 21.08 Low Low
Pain 3 5.00 Very Low Very Low Very Low
vincristine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 33 100.00 Very High Very High Very High
Skin Cancer 11 99.46 Very High Very High Very High
Glioma 2 97.60 Very High Very High Very High
Disease 4 93.76 High High
Congenital Anomalies 1 75.96 Quite High
Brain Disease 1 75.00 Quite High
Suicidal Behaviour 2 72.72 Quite High
Chromosome Aberrations 1 70.40 Quite High
Depression 3 69.36 Quite High
Amputation 1 55.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The level of I2-IR in glial tumors is increased (two-fivefold) in parallel with the abundance of the related 29/30-kD IR protein (39%), whereas the level of 45-kD IR protein is decreased (39%).
Negative_regulation (decreased) of of 45 associated with glioma
1) Confidence 0.41 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415944 Disease Relevance 0.93 Pain Relevance 0.21
Both CCSTA and malignant melanoma are immunohistochemically positive for S-100 protein (a marker for tumors derived from neural crest) and HMB-45 (a marker identifying tumors associated with melanoma) [18] suggesting that these tumors have a close relationship.
Negative_regulation (positive) of HMB-45 in neural crest associated with cancer and skin cancer
2) Confidence 0.05 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1555585 Disease Relevance 1.62 Pain Relevance 0

General Comments

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