INT83035

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 9.29
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INSR) endosome (INSR) plasma membrane (INSR)
nucleus (INSR) carbohydrate metabolic process (INSR)
Anatomy Link Frequency
eosinophil 2
mast cell 2
platelet 1
adipocytes 1
INSR (Homo sapiens)
Pain Link Frequency Relevance Heat
tramadol 120 100.00 Very High Very High Very High
alcohol 12 99.80 Very High Very High Very High
Migraine 80 99.76 Very High Very High Very High
depression 14 99.08 Very High Very High Very High
withdrawal 14 87.44 High High
addiction 4 87.28 High High
Opioid 17 86.88 High High
Central nervous system 3 85.40 High High
tolerance 19 84.60 Quite High
antidepressant 6 83.20 Quite High
Disease Link Frequency Relevance Heat
Obesity 79 100.00 Very High Very High Very High
Headache 70 99.76 Very High Very High Very High
Migraine With Aura 36 99.72 Very High Very High Very High
Depression 12 99.08 Very High Very High Very High
Diabetes Mellitus 53 98.32 Very High Very High Very High
Suicidal Behaviour 2 96.48 Very High Very High Very High
Disease 110 96.04 Very High Very High Very High
Insulin Resistance 11 95.00 High High
Dizziness 4 94.92 High High
Vomiting 6 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We performed the first replication study for the reported association of the insulin receptor gene (INSR) with migraine with aura (MA).
INSR Binding (association) of associated with migraine with aura and migraine
1) Confidence 0.47 Published 2008 Journal Genomics Section Abstract Doc Link 18455362 Disease Relevance 0.43 Pain Relevance 0.17
It can be activated upon engagement of growth factor receptors, such as EGFR, PDGFR, INSR or IGF1R, and in turn activate downstream PLC and PI3K signaling pathways [51], [52], [66].
INSR Binding (engagement) of
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.37 Pain Relevance 0
CONCLUSIONS: The regulatory mechanisms of PP-mediated hepatic IR expression and combined IR and GLUT2 endocytosis after insulin binding are defective in chronic pancreatitis and contribute to the apancreatic diabetes, which characterizes this disease.


IR Binding (binding) of
3) Confidence 0.35 Published 2007 Journal Pancreas Section Body Doc Link 17575539 Disease Relevance 0 Pain Relevance 0
In conjunction with insulin-binding the IR is internalized by endocytosis [4],[5], but the function of IR endocytosis has not been demonstrated.
IR Binding (binding) of
4) Confidence 0.16 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.37 Pain Relevance 0
In conjunction with insulin-binding the IR is internalized by endocytosis [4],[5], but the function of IR endocytosis has not been demonstrated.
IR Binding (binding) of
5) Confidence 0.14 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.37 Pain Relevance 0
Insulin controls cellular metabolism by binding to the insulin receptor (IR) at the surface of the cell (reviewed in [1]).
IR Binding (binding) of
6) Confidence 0.13 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.47 Pain Relevance 0
The density of platelet I1-IR ([125I]-p-iodoclonidine binding) is also increased in depression (135%).
IR Binding (binding) of in platelet associated with depression
7) Confidence 0.08 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415944 Disease Relevance 0.92 Pain Relevance 0.31
McCarthy et al. [22] identified five single-nucleotide polymorphisms (SNPs) within the insulin receptor gene that showed a significant association with migraine, suggesting possible functions for the insulin receptor in the pathogenesis of this disease.
insulin receptor Binding (association) of associated with migraine and disease
8) Confidence 0.06 Published 2007 Journal J Headache Pain Section Body Doc Link PMC2779399 Disease Relevance 1.35 Pain Relevance 0.79
Like tramadol IR, tramadol ER has the potential for interacting with 2D6- and 3A4- inhibitors that may alter tramadol’s efficacy by lowering M1 metabolite levels or changing tramadol’s exposure (Ultram PI 2006).
IR Binding (interacting) of associated with tramadol
9) Confidence 0.06 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386353 Disease Relevance 0.52 Pain Relevance 2.00
HOMA-IR also did not show correlation with visfatin expression on visceral adipose tissue but was positively associated with visfatin expression in subcutaneous adipocytes [21].
HOMA-IR Binding (associated) of in adipocytes associated with obesity
10) Confidence 0.06 Published 2010 Journal Diabetol Metab Syndr Section Body Doc Link PMC2857825 Disease Relevance 1.52 Pain Relevance 0
The interaction of indiplon-IR and alcohol was evaluated to assess the likelihood of these effects (Berkowitz et al 2003).
indiplon-IR Binding (interaction) of associated with alcohol
11) Confidence 0.03 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656319 Disease Relevance 0.56 Pain Relevance 0.32
The FDA gave Neurocrine an approvable letter for indiplon-IR 5 and 10 mg in May 2006.
indiplon-IR Binding (letter) of
12) Confidence 0.02 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656319 Disease Relevance 0.12 Pain Relevance 0.17
For example cross-linking of inhibitory receptor protein 60 (IR-p60)/CD300a inhibits mast cell and eosinophil activation and co-aggregation of CD300a with CCR3 using a bi-specific antibody fragment (LC1) has been shown to be effective in an animal model of asthma [77], but is still untested in human asthma.
IR-p60 Binding (cross) of in eosinophil associated with asthma
13) Confidence 0.00 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.33 Pain Relevance 0.09
For example cross-linking of inhibitory receptor protein 60 (IR-p60)/CD300a inhibits mast cell and eosinophil activation and co-aggregation of CD300a with CCR3 using a bi-specific antibody fragment (LC1) has been shown to be effective in an animal model of asthma [77], but is still untested in human asthma.
IR-p60 Binding (linking) of in eosinophil associated with asthma
14) Confidence 0.00 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.33 Pain Relevance 0.09
For example cross-linking of inhibitory receptor protein 60 (IR-p60)/CD300a inhibits mast cell and eosinophil activation and co-aggregation of CD300a with CCR3 using a bi-specific antibody fragment (LC1) has been shown to be effective in an animal model of asthma [77], but is still untested in human asthma.
IR-p60 Binding (cross) of in mast cell associated with asthma
15) Confidence 0.00 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.33 Pain Relevance 0.09
For example cross-linking of inhibitory receptor protein 60 (IR-p60)/CD300a inhibits mast cell and eosinophil activation and co-aggregation of CD300a with CCR3 using a bi-specific antibody fragment (LC1) has been shown to be effective in an animal model of asthma [77], but is still untested in human asthma.
IR-p60 Binding (linking) of in mast cell associated with asthma
16) Confidence 0.00 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.33 Pain Relevance 0.09

General Comments

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