INT83056

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Context Info
Confidence 0.11
First Reported 1999
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 2.43
Pain Relevance 5.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Insrr)
Anatomy Link Frequency
uterus 2
brain 2
neuronal 1
chondrocytes 1
spinal cord 1
Insrr (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 14 100.00 Very High Very High Very High
Kappa opioid receptor 9 100.00 Very High Very High Very High
dorsal root ganglion 11 99.64 Very High Very High Very High
MU agonist 2 99.64 Very High Very High Very High
opioid receptor 28 99.50 Very High Very High Very High
Spinal cord 35 99.32 Very High Very High Very High
Potency 6 99.26 Very High Very High Very High
Serotonin 21 99.14 Very High Very High Very High
Hippocampus 20 98.92 Very High Very High Very High
Morphine 7 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 77 99.64 Very High Very High Very High
Targeted Disruption 96 97.64 Very High Very High Very High
Sprains And Strains 22 89.36 High High
Embryonal Carcinoma 1 89.36 High High
INFLAMMATION 30 75.00 Quite High
Reprotox - General 1 4 74.44 Quite High
Apoptosis 11 70.32 Quite High
Inflammatory Pain 9 68.60 Quite High
Convulsion 31 68.32 Quite High
Nervous System Injury 3 61.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Compared with the model group, the stretching latent period extended (P < 0.05) and the number of stretching within 30 min significantly decreased (P < 0.05); and there were significant differences in the mRNA levels of ocytocin receptor and vasopressin receptor in the uterus tissue in the model group as compared with those in other 3 groups (P < 0.05, P < 0.01).
Transcription (levels) of ocytocin receptor in uterus
1) Confidence 0.11 Published 2008 Journal Zhongguo Zhen Jiu Section Body Doc Link 18405156 Disease Relevance 0.06 Pain Relevance 0
The stretching latent period and the number of stretching within 30 min were observed, and mRNA levels of ocytocin receptor (OctR) and vasopressin receptor (VasR) in the uterus tissue were detected with RT-PCR method.
Transcription (levels) of ocytocin receptor in uterus
2) Confidence 0.11 Published 2008 Journal Zhongguo Zhen Jiu Section Body Doc Link 18405156 Disease Relevance 0.07 Pain Relevance 0
Chronic in vivo treatment with opioid antagonists increases opioid receptor density and the potency of opioid agonists without altering receptor mRNA levels.
Transcription (levels) of receptor associated with mu agonist, antagonist, opioid receptor, opioid and potency
3) Confidence 0.07 Published 1999 Journal Life Sci. Section Abstract Doc Link 10416817 Disease Relevance 0.09 Pain Relevance 0.71
CXBK mice (mu-opioid receptor deficient) and outbred Swiss Webster mice were implanted s.c. with a placebo or 15 mg naltrexone pellet for 8 days, the pellets removed and 24 hr later opioid receptor density (mu, delta) and receptor mRNA level (mu) determined in whole brain; or morphine dose-response studies conducted.
Spec (determined) Transcription (level) of receptor in brain associated with opioid receptor and morphine
4) Confidence 0.07 Published 1999 Journal Life Sci. Section Abstract Doc Link 10416817 Disease Relevance 0.17 Pain Relevance 1.04
Nitric oxide (NO) suppressed the transcription of the mouse kappa opioid receptor (KOR) gene, mediated by a rapid downregulation of c-myc gene expression.
Transcription (transcription) of receptor associated with kappa opioid receptor
5) Confidence 0.05 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.09 Pain Relevance 0.21
In situ hybridization showed no changes in 5-HT(2A) receptor and serotonin transporter mRNA levels, whereas 5-HT(2C) receptor mRNA levels were reduced in certain brain regions.
Transcription (levels) of receptor in brain associated with serotonin
6) Confidence 0.04 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754082 Disease Relevance 0.15 Pain Relevance 0.31
Finally, semiquantitative RT-PCR showed a higher expression of VR1 receptor mRNA in DRG and spinal cord taken from neonatal BALB/c mice relative to B6 mice.
Transcription (expression) of receptor in spinal cord associated with dorsal root ganglion and spinal cord
7) Confidence 0.01 Published 2000 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 11076698 Disease Relevance 0.38 Pain Relevance 0.78
Because either enhanced excitation or reduced inhibition can increase the excitability of hippocampal CA3 network, we examined the mRNA levels of excitatory glutamate receptor (GluR) subunits and glutamic acid decarboxylases (GADs) expressed in the hippocampal CA3 region of the mutant mice by in situ hybridization (Fig. 7A, Table 1).
Spec (examined) Transcription (levels) of receptor associated with glutamate receptor
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.07 Pain Relevance 0.51
NR2B receptor phosphorylation was also detected after CFA injection in the hindpaw (Additional file 1, S4B).
Transcription (detected) of receptor
9) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.65 Pain Relevance 0.39
The hippocampus was chosen because it is the region with the highest expression of neuronal 5-HT2C receptor mRNA (28).
Transcription (expression) of receptor in neuronal associated with hippocampus
10) Confidence 0.01 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0.26 Pain Relevance 0.09
The mRNA levels for the putative mechanosensitive ion channels ASIC2a and 2b are increased, whereas transcript levels for the heat receptor TRPV1 are decreased.
Transcription (levels) of receptor
11) Confidence 0.01 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.28
Direct regulation of growth occurs through GC receptor (GR)-mediated gene transcription in chondrocytes [24,30,31].
Transcription (transcription) of receptor in chondrocytes
12) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.07 Pain Relevance 0
Finally, semiquantitative RT-PCR showed a higher expression of VR1 receptor mRNA in DRG and spinal cord taken from neonatal BALB/c mice relative to B6 mice.
Transcription (expression) of receptor in DRG associated with dorsal root ganglion and spinal cord
13) Confidence 0.00 Published 2000 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 11076698 Disease Relevance 0.38 Pain Relevance 0.78

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