INT83073

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Context Info
Confidence 0.23
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 14
Disease Relevance 4.40
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyrp1) oxidoreductase activity (Tyrp1)
Anatomy Link Frequency
plasma 4
liver 1
brain 1
Tyrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 82 100.00 Very High Very High Very High
TRP channel 50 100.00 Very High Very High Very High
antidepressant 24 100.00 Very High Very High Very High
cytokine 71 99.08 Very High Very High Very High
Inflammation 76 98.68 Very High Very High Very High
monoamine 5 98.20 Very High Very High Very High
Desipramine 20 96.72 Very High Very High Very High
fluoxetine 13 96.04 Very High Very High Very High
depression 49 95.92 Very High Very High Very High
ischemia 26 80.28 Quite High
Disease Link Frequency Relevance Heat
Recurrence 5 99.60 Very High Very High Very High
Sepsis 14 99.44 Very High Very High Very High
Injury 171 98.84 Very High Very High Very High
Stress 332 98.72 Very High Very High Very High
INFLAMMATION 92 98.68 Very High Very High Very High
Depression 53 95.92 Very High Very High Very High
Infection 44 87.08 High High
Renal Disease 9 82.32 Quite High
Cv Unclassified Under Development 26 80.28 Quite High
Schizophrenia 14 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On this basis, IDO would be expected to decrease plasma and brain Trp levels but increase its downstream metabolites Kyn and KYNA [29].
Negative_regulation (decrease) of Trp in brain
1) Confidence 0.23 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0 Pain Relevance 0.06
Our assessment of both TDO and IDO enzyme activities from liver lysates, however, showed a loss in the conversion of Trp to Kyn in Tdo-/- compared with Tdo+/+ mice (Figure 1F), suggesting that the compensatory mechanism(s) may function in extra-hepatic tissues and, in part, play a role in decreasing Trp level and increasing Kyn level.
Negative_regulation (decreasing) of Trp in liver
2) Confidence 0.20 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.06 Pain Relevance 0
CONCLUSIONS: Rapid depletion of plasma TRP transiently reverses the antidepressant response in many patients on FLU but not DMI.
Negative_regulation (depletion) of TRP in plasma
3) Confidence 0.20 Published 1999 Journal Biol. Psychiatry Section Body Doc Link 10418696 Disease Relevance 0.05 Pain Relevance 0
This study further investigates the relationship of relapse during TRP depletion to antidepressant type in nonrefractory, depressed patients randomly assigned to treatment with either DMI or fluoxetine (FLU).
Spec (investigates) Negative_regulation (depletion) of TRP associated with desipramine, antidepressant, recurrence and fluoxetine
4) Confidence 0.20 Published 1999 Journal Biol. Psychiatry Section Abstract Doc Link 10418696 Disease Relevance 0.10 Pain Relevance 0.61
One session led to rapid TRP depletion and the other did not.
Negative_regulation (depletion) of TRP
5) Confidence 0.17 Published 1999 Journal Biol. Psychiatry Section Body Doc Link 10418696 Disease Relevance 0.07 Pain Relevance 0
Depressive relapse during TRP depletion appears to be more related to antidepressant type than to patient variables since patients were randomly assigned to the two treatments.
Negative_regulation (depletion) of TRP
6) Confidence 0.17 Published 1999 Journal Biol. Psychiatry Section Body Doc Link 10418696 Disease Relevance 0 Pain Relevance 0
We have previously reported that rapid TRP depletion more frequently reversed the antidepressant response to monoamine oxidase inhibitors and 5-HT reuptake inhibitors than to desipramine (DMI).
Negative_regulation (depletion) of TRP associated with desipramine, antidepressant and monoamine
7) Confidence 0.17 Published 1999 Journal Biol. Psychiatry Section Abstract Doc Link 10418696 Disease Relevance 0 Pain Relevance 0.58
Importantly, we showed that IDO1 is not only expressed on the mRNA level but is enzymatically active leading to an early decrease of plasma Trp (Fig. 2F) and serotonin levels (Fig. 2I) and transiently increased Kyn concentrations at 6- and 12-h after acute stress (Fig. 2G) whereas Quin levels were not significantly changed (Fig. 2J) and Kyna levels were not significantly altered until 12-h after stress exposure (Fig. 2K).
Negative_regulation (decrease) of Trp in plasma associated with stress and serotonin
8) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.85 Pain Relevance 0.11
The analysis of Trp-kynurenine pathway metabolites in repeatedly stressed mice showed that plasma Trp and serotonin levels were reduced and Kyna accumulated while other kynurenines were not altered (Table 1).
Negative_regulation (reduced) of Trp in plasma associated with serotonin
9) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.50 Pain Relevance 0.21
Depletion of Trp, the precursor molecule of serotonin, promotes mood alterations in healthy individuals [29]–[31] and depression-like behavior in stressed animals [29].
Negative_regulation (Depletion) of Trp associated with depression and serotonin
10) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.75 Pain Relevance 0.16
When Trp as the precursor of serotonin is depleted, mood alterations develop even in healthy humans [30], [31].
Negative_regulation (depleted) of Trp associated with serotonin
11) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.52 Pain Relevance 0.20
Copy numbers of individual TRP channel transcripts are given in relation to those of 18S cDNA.
Negative_regulation (numbers) of TRP associated with trp channel
12) Confidence 0.11 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.19
On this basis, IDO would be expected to decrease plasma and brain Trp levels but increase its downstream metabolites Kyn and KYNA [29].
Negative_regulation (decrease) of Trp in plasma
13) Confidence 0.08 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0 Pain Relevance 0.06
Thus chloroquine and inhibition of TRP-9 protect from sepsis-induced AKI [91].
Negative_regulation (inhibition) of TRP-9 associated with injury and sepsis
14) Confidence 0.03 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.50 Pain Relevance 0.45

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