INT83095

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 4.06
Pain Relevance 5.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (BDKRB2) plasma membrane (BDKRB2) signal transducer activity (BDKRB2)
BDKRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
acular 105 100.00 Very High Very High Very High
B1 receptor 85 100.00 Very High Very High Very High
b2 receptor 55 100.00 Very High Very High Very High
Pain 151 99.04 Very High Very High Very High
bradykinin 263 97.60 Very High Very High Very High
Inflammation 93 93.84 High High
Analgesic 10 92.40 High High
Kinase C 15 85.88 High High
Eae 70 82.32 Quite High
cytokine 26 82.04 Quite High
Disease Link Frequency Relevance Heat
Injury 160 100.00 Very High Very High Very High
Pain 161 99.04 Very High Very High Very High
INFLAMMATION 98 93.84 High High
Inflammatory Pain 65 82.32 Quite High
Rheumatoid Arthritis 15 77.36 Quite High
Osteoarthritis 15 77.08 Quite High
Frailty 10 42.48 Quite Low
Hyperalgesia 10 34.20 Quite Low
Neuropathic Pain 5 22.40 Low Low
Nociception 10 21.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that kinins autoregulate B2R and B1R expression in favor of B1R.
Regulation (autoregulate) of Gene_expression (expression) of B2R
1) Confidence 0.59 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.28 Pain Relevance 0.78
The correlation between the sum of pain intensity scores as measured by VAS and the up-regulation of gene expression of BDKRB1 and BDKRB2 following tissue injury was examined using Pearson's correlation coefficients (Fig. 2 b-e).
Regulation (regulation) of Gene_expression (expression) of BDKRB2 associated with pain and injury
2) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.87 Pain Relevance 1.27
In the present study, we did not see a correlation between B2 receptor and TRPV1 gene expression.
Regulation (correlation) of Gene_expression (expression) of B2 receptor associated with b2 receptor
3) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.63 Pain Relevance 0.72
Ketorolac treatment did not have a significant effect on the gene expression of either BDKRB1 (p = 0.71; unpaired t-test) or BDKRB2 (p = 0.73; unpaired t-test).

3.

Regulation (effect) of Gene_expression (expression) of BDKRB2 associated with acular
4) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.75 Pain Relevance 1.16
Effect of tissue injury and ketorolac treatment on BDKRB1 and BDKRB2 gene expression at the site of tissue injury
Regulation (Effect) of Gene_expression (expression) of BDKRB2 associated with injury and acular
5) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.63 Pain Relevance 0.74
Interestingly, the change in gene expression of TRPV1 was correlated to the change in gene expression of B1 receptor but not B2 receptor.


Regulation (change) of Gene_expression (expression) of B2 receptor associated with b1 receptor and b2 receptor
6) Confidence 0.25 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2834653 Disease Relevance 0.90 Pain Relevance 0.72

General Comments

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