INT83119

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Context Info
Confidence 0.42
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 17.52
Pain Relevance 5.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
macrophages 9
monocytes 5
plasma 4
alveolar macrophages 4
dendritic cells 4
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 904 100.00 Very High Very High Very High
agonist 174 99.48 Very High Very High Very High
Inflammation 965 98.00 Very High Very High Very High
Opioid 10 91.76 High High
chemokine 214 89.16 High High
Leflunomide 1 88.28 High High
Pain 10 79.52 Quite High
Chronic pancreatitis 10 74.96 Quite High
methotrexate 37 74.24 Quite High
rheumatoid arthritis 70 72.32 Quite High
Disease Link Frequency Relevance Heat
Cancer 210 100.00 Very High Very High Very High
Necrosis 24 100.00 Very High Very High Very High
Asthma 2625 99.90 Very High Very High Very High
Lymphatic System Cancer 19 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 98.80 Very High Very High Very High
Breast Cancer 4 98.36 Very High Very High Very High
INFLAMMATION 1026 98.00 Very High Very High Very High
Infection 135 97.88 Very High Very High Very High
Apoptosis 97 97.52 Very High Very High Very High
Hepatitis C Virus Infection 119 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because we have observed marked defects in interleukin-12 (IL-12) production in CTCL and because IL-12 is critical for antitumor cytotoxic T-cell responses, we initiated a phase I dose escalation trial with recombinant human IL-12 (rhIL-12) where patients received either 50, 100, or 300 ng/kg rhIL-12 twice weekly subcutaneously or intralesionally for up to 24 weeks.
Negative_regulation (defects) of Gene_expression (production) of interleukin-12 in cytotoxic T-cell associated with lymphatic system cancer
1) Confidence 0.42 Published 1999 Journal Blood Section Abstract Doc Link 10419880 Disease Relevance 0.57 Pain Relevance 0.05
Because we have observed marked defects in interleukin-12 (IL-12) production in CTCL and because IL-12 is critical for antitumor cytotoxic T-cell responses, we initiated a phase I dose escalation trial with recombinant human IL-12 (rhIL-12) where patients received either 50, 100, or 300 ng/kg rhIL-12 twice weekly subcutaneously or intralesionally for up to 24 weeks.
Negative_regulation (defects) of Gene_expression (production) of IL-12 in cytotoxic T-cell associated with lymphatic system cancer
2) Confidence 0.42 Published 1999 Journal Blood Section Abstract Doc Link 10419880 Disease Relevance 0.57 Pain Relevance 0.05
SOCS-3 has been reported to be a negative regulator of IL-12 signaling by preventing STAT-4 binding to the IL-12R?
Negative_regulation (regulator) of Gene_expression (signaling) of IL-12
3) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.22 Pain Relevance 0
Successfully cured patients showed reduced IL-12 and IL-10 levels in the plasma and two-fold or more increase in Th1 type-cytokines IFN-?
Negative_regulation (reduced) of Gene_expression (levels) of IL-12 in plasma associated with cytokine
4) Confidence 0.15 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2910702 Disease Relevance 0.73 Pain Relevance 0.17
Similarly, they suppressed LPS-stimulated IL-10 and IL-12 production in THP-1 matured to monocytes by 1alpha,25-dihydroxyvitamin D3.
Negative_regulation (suppressed) of Gene_expression (production) of IL-12 in monocytes
5) Confidence 0.14 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.16
Endomorphins 1 and 2 inhibited lipopolysaccharide (LPS)-stimulated IL-10 and IL-12 production in THP-1 differentiated to macrophage-like cells by phorbol 12-myristate 13-acetate (PMA).
Negative_regulation (inhibited) of Gene_expression (production) of IL-12 in THP-1
6) Confidence 0.14 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.14
Treatment of NBEC with IL-12 down-regulated production of these cytokines.


Negative_regulation (down) of Gene_expression (production) of IL-12 associated with cytokine
7) Confidence 0.14 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2702099 Disease Relevance 1.00 Pain Relevance 0.10
Treatment of NBEC with IL-12 down-regulated production of these cytokines.


Negative_regulation (regulated) of Gene_expression (production) of IL-12 associated with cytokine
8) Confidence 0.14 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2702099 Disease Relevance 1.00 Pain Relevance 0.10
RDP-58 is an oral decapeptide inhibiting TNF production, but the molecule is also an inhibitor of p38 MAP kinase and of IL-12 synthesis.
Negative_regulation (inhibitor) of Gene_expression (synthesis) of IL-12
9) Confidence 0.11 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721293 Disease Relevance 0.76 Pain Relevance 0.16
The role of glucocorticoids is to inhibit the production of proinflammatory cytokines such as tumor necrosis factor (TNF)-A, interferon (IFN)-Y and interleukin-12 (IL-12), and to stimulate the production of anti-inflammatory cytokines such as IL-10, IL-4 and transforming growth factor (TGF)-B [86].
Negative_regulation (inhibit) of Gene_expression (production) of interleukin-12 associated with necrosis, inflammation, cancer and cytokine
10) Confidence 0.11 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1629015 Disease Relevance 1.61 Pain Relevance 0.31
Sulfasalazine potently inhibits the production of IL-12 in a dose-dependent manner in mouse macrophages stimulated with lipopolysaccharide.
Negative_regulation (inhibits) of Gene_expression (production) of IL-12 in macrophages
11) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.46 Pain Relevance 0.31
Negligible decline in plasma IL-12 and IL-10 levels, negligible elevation of IFN-?
Negative_regulation (decline) of Gene_expression (levels) of IL-12 in plasma
12) Confidence 0.10 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.17 Pain Relevance 0.04
In accord with their ability to suppress IL-12 production, when ?
Negative_regulation (suppress) of Gene_expression (production) of IL-12
13) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.51 Pain Relevance 0.50
Results: We found that IL-10 fully inhibited human DC maturation, as determined by the reduced expression of costimulatory molecules (CD80, CD86), stimulatory cytokines (IL-6, IL-12), and improvement in phagocytic activity.
Negative_regulation (reduced) of Spec (determined) Gene_expression (expression) of IL-12 in CD86 associated with cytokine
14) Confidence 0.07 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.28 Pain Relevance 0.18
In man, IL-12 production is decreased in PBMCs, alveolar macrophages and bronchial biopsies of patients with mild asthma and IL-12 synthesis is further attenuated in PBMCs from severe persistent asthma compared to mild asthma [227].
Negative_regulation (decreased) of Gene_expression (production) of IL-12 in alveolar macrophages associated with asthma
15) Confidence 0.06 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.17 Pain Relevance 0.23
In man, IL-12 production is decreased in PBMCs, alveolar macrophages and bronchial biopsies of patients with mild asthma and IL-12 synthesis is further attenuated in PBMCs from severe persistent asthma compared to mild asthma [227].
Negative_regulation (attenuated) of Gene_expression (synthesis) of IL-12 in alveolar macrophages associated with asthma
16) Confidence 0.06 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.24 Pain Relevance 0.23
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Negative_regulation (decrease) of Gene_expression (expression) of IL-12 in dendritic cells
17) Confidence 0.06 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.57 Pain Relevance 0.21
2-agonists are potent and selective inhibitors of LPS- and CD40-CD40L-stimulated IL-12 production by human macrophages and dendritic cells [44].
Negative_regulation (inhibitors) of Gene_expression (production) of IL-12 in macrophages associated with agonist
18) Confidence 0.06 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.58 Pain Relevance 0.54
and increased levels of IL-4, IL-5, and IL-10, an effect that is thought to be mediated by decreasing IL-12 production thereby suggesting that ?
Negative_regulation (decreasing) of Gene_expression (production) of IL-12
19) Confidence 0.06 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.60 Pain Relevance 0.54
Breast cancer is another example with decreased T cell stimulatory ability, which also exhibit decreased IL-12 production and increased IL-10 production [8].
Negative_regulation (decreased) of Gene_expression (production) of IL-12 in T cell associated with breast cancer
20) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.33 Pain Relevance 0.22

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