INT83169

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Context Info
Confidence 0.42
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.58
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck, Lep) extracellular region (Cck, Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
stomach 2
Cck (Rattus norvegicus)
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 74 100.00 Very High Very High Very High
Neuropeptide 2 97.12 Very High Very High Very High
qutenza 14 96.96 Very High Very High Very High
Inflammation 8 84.40 Quite High
antagonist 9 83.80 Quite High
vagus nerve 10 82.48 Quite High
aspirin 8 50.56 Quite High
anesthesia 1 33.84 Quite Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 4 100.00 Very High Very High Very High
Obesity 4 92.16 High High
INFLAMMATION 8 84.40 Quite High
Colitis 12 75.00 Quite High
Rheumatoid Arthritis 2 73.44 Quite High
Ganglion Cysts 5 69.64 Quite High
Gastric Motility Disorder 1 61.72 Quite High
Gastric Fistula 1 46.76 Quite Low
Urological Neuroanatomy 2 35.44 Quite Low
Eating Disorder 2 27.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that: (1) exogenous leptin or that released endogenously by CCK or meal exerts a potent gastroprotective action depending upon vagal activity, and involving hyperemia probably mediated by NO and sensory nerves but unrelated to endogenous prostaglandins; (2) leptin mimics the gastroprotective effect of CCK and probably mediates the protective and hyperemic actions of CCK in the rat stomach.
CCK Binding (mediates) of leptin in stomach associated with increased venous pressure under development and cholecystokinin
1) Confidence 0.42 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10422768 Disease Relevance 0.18 Pain Relevance 0.43
Leptin and cholecystokinin (CCK) have a synergistic interaction in the suppression of food intake, and afford similar gastroprotective activity.
CCK Binding (interaction) of Leptin associated with cholecystokinin
2) Confidence 0.39 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 14599722 Disease Relevance 0.31 Pain Relevance 0.60
These results indicate the existence of a functional interaction between leptin and CCK receptors leading to inhibition of gastric emptying and short-term suppression of food intake, providing an additional feedback control in producing satiety.
CCK Binding (interaction) of leptin
3) Confidence 0.37 Published 2007 Journal Physiol Res Section Abstract Doc Link 16792473 Disease Relevance 0.13 Pain Relevance 0.04
We conclude that: (1) exogenous leptin or that released endogenously by CCK or meal exerts a potent gastroprotective action depending upon vagal activity, and involving hyperemia probably mediated by NO and sensory nerves but unrelated to endogenous prostaglandins; (2) leptin mimics the gastroprotective effect of CCK and probably mediates the protective and hyperemic actions of CCK in the rat stomach.
CCK Binding (mediates) of leptin in stomach associated with increased venous pressure under development and cholecystokinin
4) Confidence 0.36 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10422768 Disease Relevance 0.17 Pain Relevance 0.36
Recent studies have shown a synergistic interaction between leptin and cholecystokinin (CCK) leading to suppression of food intake, which involves CCK-1 receptors and capsaicin-sensitive vagal fibres.
CCK Binding (interaction) of leptin associated with qutenza and cholecystokinin
5) Confidence 0.35 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11488950 Disease Relevance 0.23 Pain Relevance 0.37
Leptin and cholecystokinin (CCK) have a synergistic interaction in the suppression of food intake, and afford similar gastroprotective activity.
cholecystokinin Binding (interaction) of Leptin associated with cholecystokinin
6) Confidence 0.34 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 14599722 Disease Relevance 0.31 Pain Relevance 0.60
Recent studies have shown a synergistic interaction between leptin and cholecystokinin (CCK) leading to suppression of food intake, which involves CCK-1 receptors and capsaicin-sensitive vagal fibres.
cholecystokinin Binding (interaction) of leptin associated with qutenza and cholecystokinin
7) Confidence 0.31 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11488950 Disease Relevance 0.23 Pain Relevance 0.37

General Comments

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