INT83198

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Context Info
Confidence 0.64
First Reported 1999
Last Reported 2010
Negated 6
Speculated 2
Reported most in Body
Documents 78
Total Number 80
Disease Relevance 35.69
Pain Relevance 17.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) aging (Nos3) Golgi apparatus (Nos3)
cytoplasm (Nos3) signal transduction (Nos3) oxidoreductase activity (Nos3)
Anatomy Link Frequency
endothelial cells 6
neutrophil 5
dorsal horn 5
spinal cord 4
blood 3
Nos3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 288 100.00 Very High Very High Very High
ketamine 163 100.00 Very High Very High Very High
intrathecal 144 100.00 Very High Very High Very High
neuralgia 3 100.00 Very High Very High Very High
Angina 13 99.98 Very High Very High Very High
Calcitonin gene-related peptide 35 99.82 Very High Very High Very High
Spinal cord 293 99.74 Very High Very High Very High
nMDA receptor 158 99.72 Very High Very High Very High
antagonist 157 99.58 Very High Very High Very High
Cholecystokinin 24 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 6 100.00 Very High Very High Very High
Neuralgia 2 100.00 Very High Very High Very High
Cv General 3 Under Development 14 99.98 Very High Very High Very High
Diabetes Mellitus 822 99.96 Very High Very High Very High
Arthritis 99 99.84 Very High Very High Very High
Cystitis 6 99.84 Very High Very High Very High
End Stage Liver Disease 2 99.60 Very High Very High Very High
Pulmonary Hypertension 150 99.54 Very High Very High Very High
Natriuresis 11 99.48 Very High Very High Very High
Aseptic Necrosis Of Bone 3 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, we demonstrated a novel redox mechanism in IP-induced eNOS and GLUT-4 translocation and the role of caveolar paradox in making the heart euglycemic during the process of ischemia, leading to myocardial protection in a clinically relevant rat ischemic model.
Positive_regulation (induced) of eNOS in heart associated with ischemia
1) Confidence 0.64 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17277024 Disease Relevance 0.23 Pain Relevance 0.18
Immunohistochemical studies showed that eNOS was increased in vascular endothelial cells and Schwann cells, but not in inflammatory cells, during the peak stage of EAN.
Neg (not) Positive_regulation (increased) of eNOS in Schwann cells associated with inflammation and neuritis
2) Confidence 0.60 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 12020959 Disease Relevance 0.79 Pain Relevance 1.00
Consequently, we postulated that caveolin-1 expression increased in the sciatic nerves with EAN; this possibly mediated either molecular trafficking or nitric oxide generation partly through the activation of eNOS in vascular endothelial cells, as well as in inflammatory macrophages in EAN and/or cellular apoptosis of inflammatory cells.
Positive_regulation (activation) of eNOS in endothelial cells associated with inflammation, sciatic nerve, apoptosis and neuritis
3) Confidence 0.59 Published 2006 Journal Brain Res. Section Abstract Doc Link 16806125 Disease Relevance 1.11 Pain Relevance 0.95
These results suggest that the gastric ulcerogenic response to cold-restraint stress is enhanced in arthritic rats, similar to that induced by NSAIDs, and this phenomenon may be causally associated with the upregulation of eNOS/NO in addition to iNOS/NO.
Positive_regulation (upregulation) of eNOS associated with stress, cinod and arthritis
4) Confidence 0.59 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19881222 Disease Relevance 0.91 Pain Relevance 0.10
Both MnSOD and eNOS in the mesenteric resistance arteries were increased in CAP-HS compared with CAP-NS, CON-HS, and CON-NS (P<0.05).
Positive_regulation (increased) of eNOS
5) Confidence 0.58 Published 2004 Journal Acta Pharmacol. Sin. Section Body Doc Link 15569407 Disease Relevance 0.06 Pain Relevance 0
In parallel experiments L-arginine and NOS cofactors combined to either EDTA or calcium in the incubation medium increase the activities of both cNOS and iNOS in blood cells (except monocyte cNOS, which is inhibited).
Positive_regulation (increase) of cNOS in blood cells
6) Confidence 0.52 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0 Pain Relevance 0
We also observed that the progression of diabetes from 14-days to 28-days upregulated iNOS and eNOS in thoracic aorta and kidney cortex while decreasing aortic and renal blood flow that correlated well with systemic and local increase in NOx levels in thoracic aorta.
Positive_regulation (upregulated) of eNOS in blood associated with diabetes mellitus
7) Confidence 0.50 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.78 Pain Relevance 0.04
Stockklauser-Farber et al. [7] demonstrated an increased myocardial NOS (iNOS and eNOS) activity that reached maximal values after 4 wk and 6 wk diabetes.
Positive_regulation (increased) of eNOS associated with diabetes mellitus
8) Confidence 0.50 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.83 Pain Relevance 0.08
Also in kidney cortex in 28-days diabetes, eNOS and iNOS were significantly increased as compared to 14-days diabetes and control groups.
Positive_regulation (increased) of eNOS in kidney cortex associated with diabetes mellitus
9) Confidence 0.50 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.32 Pain Relevance 0.15
Cellular "morphinergic" signaling is mediated by cognate six-transmembrane helical domain (TMH) micro3 and micro4 opiate receptors linked to activation of constitutive NO synthase (cNOS).
Positive_regulation (activation) of constitutive NO synthase associated with opiate
10) Confidence 0.47 Published 2009 Journal Med. Sci. Monit. Section Abstract Doc Link 19396050 Disease Relevance 0.22 Pain Relevance 1.17
Cellular "morphinergic" signaling is mediated by cognate six-transmembrane helical domain (TMH) micro3 and micro4 opiate receptors linked to activation of constitutive NO synthase (cNOS).
Positive_regulation (activation) of cNOS associated with opiate
11) Confidence 0.47 Published 2009 Journal Med. Sci. Monit. Section Abstract Doc Link 19396050 Disease Relevance 0.22 Pain Relevance 1.17
Immunoblotting showed endothelial nitric oxide synthase (eNOS) to be up-regulated in cystitis, and immunohistochemistry revealed the change to occur in the urothelium and in the suburothelial layer.
Positive_regulation (up-regulated) of endothelial nitric oxide synthase associated with cystitis
12) Confidence 0.46 Published 2005 Journal Auton Neurosci Section Abstract Doc Link 16125470 Disease Relevance 0.42 Pain Relevance 0.05
Immunoblotting showed endothelial nitric oxide synthase (eNOS) to be up-regulated in cystitis, and immunohistochemistry revealed the change to occur in the urothelium and in the suburothelial layer.
Positive_regulation (up-regulated) of eNOS associated with cystitis
13) Confidence 0.46 Published 2005 Journal Auton Neurosci Section Abstract Doc Link 16125470 Disease Relevance 0.41 Pain Relevance 0.05
The expression of CCK-A receptor mRNA and cNOS mRNA was significantly increased in rats treated with CCK-8 and camostate, whereas CCK-B receptor mRNA remained unaffected.
Positive_regulation (increased) of cNOS associated with cholecystokinin
14) Confidence 0.45 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10458643 Disease Relevance 0.88 Pain Relevance 0.78
These findings suggest that the vascular damage in our animal model is limited to the endothelium per se; however, the stimulated activation of eNOS seems not to be impaired nor does the utilization of the precursor L-arginine.
Positive_regulation (activation) of eNOS in endothelium
15) Confidence 0.43 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC3014714 Disease Relevance 0.90 Pain Relevance 0.03
Increased immunoreactivities of eNOS, iNOS and TGF-beta were observed in the non-fluid resuscitated group in these organs; mild, moderate, moderate and strong immunoreactivities were seen in the albumin, gelatin, physiological saline and dextran-70 treated groups, respectively.
Positive_regulation (Increased) of eNOS
16) Confidence 0.43 Published 2006 Journal Acta Histochem. Section Abstract Doc Link 16762404 Disease Relevance 0.24 Pain Relevance 0.06
Several divalent cations (Mn++, Zn++ and Fe++) suppressed eNOS activity in crude cell extracts and intact cells whereas Cu++ increased eNOS activation [30].
Positive_regulation (activation) of eNOS
17) Confidence 0.42 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1501003 Disease Relevance 0.91 Pain Relevance 0.23
Although the present study provides new evidence on this subject, several questions remain unanswered, such as the functional significance of decreased nNOS together with increased iNOS/eNOS after NMDA receptor blockade in spinal cord of monoarthritic rats, because no studies have examined whether nNOS loss and its possibly associated antinociceptive effect could be functionally compensated for by increases in iNOS and/or eNOS.


Positive_regulation (increased) of eNOS in spinal cord associated with nmda receptor, antinociceptive and spinal cord
18) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206346 Disease Relevance 0.59 Pain Relevance 0.77
Dyn A(1-17) 20 nmol significantly ameliorated Dyn-induced neurological outcome, but TF and FF remained inhibited. 7-nitroindazole also significantly antagonized the increases of cNOS activities and ncNOS-IR in the ventral spinal cord at 4 h after i.t.
Positive_regulation (increases) of cNOS in ventral
19) Confidence 0.38 Published 1999 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11601043 Disease Relevance 0 Pain Relevance 0
Dyn A(1-17) 20 nmol also significantly increased the activities of cNOS in the ventral spinal cord but did not affect cNOS activities in the dorsal spinal cord.
Neg (not) Positive_regulation (increased) of cNOS in spinal cord
20) Confidence 0.38 Published 1999 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11601043 Disease Relevance 0.06 Pain Relevance 0

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