INT83200

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 48
Total Number 51
Disease Relevance 24.75
Pain Relevance 12.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) aging (Nos3) Golgi apparatus (Nos3)
cytoplasm (Nos3) signal transduction (Nos3) oxidoreductase activity (Nos3)
Anatomy Link Frequency
endothelial cells 8
sciatic nerves 6
myocardium 4
pia mater 4
endothelium 4
Nos3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 25 100.00 Very High Very High Very High
Cholecystokinin 24 100.00 Very High Very High Very High
Dorsal horn 96 99.96 Very High Very High Very High
agonist 31 99.96 Very High Very High Very High
ketamine 55 99.88 Very High Very High Very High
Inflammation 132 99.74 Very High Very High Very High
ischemia 427 99.66 Very High Very High Very High
antagonist 106 99.58 Very High Very High Very High
Peripheral nervous system 4 99.50 Very High Very High Very High
intrathecal 48 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 17 100.00 Very High Very High Very High
Autoimmune Disease 2 99.88 Very High Very High Very High
Apoptosis 26 99.86 Very High Very High Very High
Arthritis 37 99.84 Very High Very High Very High
Stress 175 99.76 Very High Very High Very High
INFLAMMATION 163 99.74 Very High Very High Very High
Cv Unclassified Under Development 428 99.66 Very High Very High Very High
Diabetes Mellitus 441 99.60 Very High Very High Very High
Pulmonary Hypertension 300 99.06 Very High Very High Very High
Injury 121 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, Western blot analysis showed that eNOS expression in the mesentery was increased in the Estrogen group compared with the Placebo group.
Positive_regulation (increased) of Gene_expression (expression) of eNOS in mesentery
1) Confidence 0.70 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15231501 Disease Relevance 0.53 Pain Relevance 0.07
Our results show that chronic exercise increases both iNOS and eNOS gene expression in endothelium.
Positive_regulation (increases) of Gene_expression (expression) of eNOS gene in endothelium
2) Confidence 0.68 Published 2002 Journal J. Biomed. Sci. Section Abstract Doc Link 11914582 Disease Relevance 0 Pain Relevance 0.08
Chronic exercise upregulates endothelial nitric oxide synthase (eNOS) gene expression.
Positive_regulation (upregulates) of Gene_expression (expression) of eNOS
3) Confidence 0.68 Published 2002 Journal J. Biomed. Sci. Section Abstract Doc Link 11914582 Disease Relevance 0 Pain Relevance 0.07
Thus for the first time we showed that mesenteric eNOS overexpression could explain at least partly why chronic estrogen treatment suppressed the enhanced cardiovascular responses to psychological stress in the ovariectomized rat.
Positive_regulation (overexpression) of Gene_expression (overexpression) of eNOS associated with stress
4) Confidence 0.61 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15231501 Disease Relevance 0.54 Pain Relevance 0.07
Chronic exercise increases both inducible and endothelial nitric oxide synthase gene expression in endothelial cells of rat aorta.
Positive_regulation (increases) of Gene_expression (expression) of endothelial nitric oxide synthase in endothelial cells
5) Confidence 0.59 Published 2002 Journal J. Biomed. Sci. Section Title Doc Link 11914582 Disease Relevance 0 Pain Relevance 0.08
To take in consideration that EDTA could lead to increase in NO plasmatic levels through increase in eNOS expression, we further performed histological evaluations on two additional groups of rats, to verify whether the eNOS inhibitor L-NAME was able to block the protective effect of EDTA in renal ischemic injury.
Positive_regulation (increase) of Gene_expression (expression) of eNOS associated with injury
6) Confidence 0.55 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1501003 Disease Relevance 0.82 Pain Relevance 0.33
The use of L-NAME together with EDTA before the induction of Isc and Isc/R abrogated the increase in eNOS expression due to EDTA treatment alone (data not shown).


Positive_regulation (increase) of Gene_expression (expression) of eNOS associated with ischemia
7) Confidence 0.55 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1501003 Disease Relevance 0.59 Pain Relevance 0.33
There is evidence in the literature that during the inflammatory process the expression of eNOS or its activity is enhanced [38] and iNOS is induced [39].
Positive_regulation (enhanced) of Gene_expression (expression) of eNOS associated with inflammation
8) Confidence 0.50 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.73 Pain Relevance 0.30
Increased expression of eNOS in afferent arterioles and glomeruli was found by Sugimoto et al. [36].
Positive_regulation (Increased) of Gene_expression (expression) of eNOS in afferent arterioles
9) Confidence 0.50 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.83 Pain Relevance 0.07
We found that (1) expression of iNOS and eNOS mRNA in endothelial cells was increased by chronic exercise and (2) chronic exercise blunted phenylephrine-induced vascular responses, probably by increasing NO release via iNOS.
Positive_regulation (increased) of Gene_expression (expression) of eNOS in endothelial cells
10) Confidence 0.49 Published 2002 Journal J. Biomed. Sci. Section Abstract Doc Link 11914582 Disease Relevance 0 Pain Relevance 0.09
Detectable signals for CCK-A and B receptor mRNAs as well as for cNOS mRNA expression were recorded by RT-PCR in the vehicle control gastric mucosa.
Positive_regulation (signals) of Gene_expression (expression) of cNOS associated with cholecystokinin
11) Confidence 0.49 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10458643 Disease Relevance 0.99 Pain Relevance 0.83
The mucosal expression levels of eNOS and iNOS but not nNOS mRNAs were enhanced in arthritic rats compared with normal rats.
Positive_regulation (enhanced) of Gene_expression (expression) of eNOS associated with arthritis
12) Confidence 0.45 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19881222 Disease Relevance 1.15 Pain Relevance 0.21
In this study, we investigated mucosal expression of ET-1, interleukin-4 (IL-4), and the activity of constitutive nitric oxide synthase (cNOS) during indomethacin-induced gastric mucosal injury, and evaluated the effect of antiulcer agents on this process.
Spec (investigated) Positive_regulation (mucosal) of Spec (investigated) Gene_expression (expression) of cNOS associated with injury
13) Confidence 0.44 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10424717 Disease Relevance 0.43 Pain Relevance 0.10
Therefore, we developed a technique to increase the local production of NO in vivo by the transfer of endothelial NO synthase (eNOS) gene into the NTS.
Positive_regulation (transfer) of Gene_expression (transfer) of eNOS
14) Confidence 0.44 Published 2004 Journal Methods Mol. Biol. Section Abstract Doc Link 15199246 Disease Relevance 0 Pain Relevance 0.14
We have developed a novel technique of endothelial nitric oxide synthase (eNOS) gene transfer into the NTS in vivo.
Positive_regulation (transfer) of Gene_expression (transfer) of eNOS
15) Confidence 0.44 Published 2001 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11458677 Disease Relevance 0 Pain Relevance 0.10
Therefore, eNOS production could be induced in the MSC-transplanted limbs of STZ-induced diabetic rats.
Positive_regulation (induced) of Gene_expression (production) of eNOS in limbs associated with diabetes mellitus
16) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.62 Pain Relevance 0.07
Western blot analysis showed that both eNOS and iNOS expressions in the sciatic nerves of rats increased significantly during the peak stage of EAN, but declined thereafter.
Positive_regulation (increased) of Gene_expression (expressions) of eNOS in sciatic nerves associated with sciatic nerve and neuritis
17) Confidence 0.43 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 12020959 Disease Relevance 0.72 Pain Relevance 0.83
However, iNOS was found mainly in inflammatory macrophages in sciatic nerve EAN lesions.These findings suggest that, depending on the stage of peripheral nervous system autoimmune disease, the increased expressions of both eNOS and iNOS might be involved in either the production of detrimental effects during the induction stage of EAN or in the recovery from EAN paralysis.
Positive_regulation (increased) of Gene_expression (expressions) of eNOS in sciatic nerve associated with autoimmune disease, peripheral nervous system, inflammation, sciatic nerve, neuritis and paralysis
18) Confidence 0.43 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 12020959 Disease Relevance 1.07 Pain Relevance 1.03
Chronic exercise upregulates endothelial nitric oxide synthase (eNOS) gene expression.
Positive_regulation (upregulates) of Gene_expression (expression) of endothelial nitric oxide synthase
19) Confidence 0.43 Published 2002 Journal J. Biomed. Sci. Section Abstract Doc Link 11914582 Disease Relevance 0 Pain Relevance 0.07
In the present study we demonstrated involvement of ROS in IP-mediated GLUT-4 translocation along with increased expression of caveolin (Cav)-3, phospho (p)-endothelial nitric oxide synthase (eNOS), p-Akt, and decreased expression of Cav-1.
Positive_regulation (increased) of Gene_expression (expression) of endothelial nitric oxide synthase
20) Confidence 0.41 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17277024 Disease Relevance 0.50 Pain Relevance 0.29

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