INT83206

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Context Info
Confidence 0.45
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.34
Pain Relevance 3.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
neurons 2
spinal cord 2
brain 2
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 92 100.00 Very High Very High Very High
Morphine 18 100.00 Very High Very High Very High
Clonidine 11 98.82 Very High Very High Very High
Spinal cord 2 98.28 Very High Very High Very High
addiction 4 98.08 Very High Very High Very High
Neurobehavioral 6 96.40 Very High Very High Very High
long-term potentiation 8 92.64 High High
Neurotransmitter 6 90.20 High High
Central nervous system 7 87.36 High High
Antinociceptive 1 86.04 High High
Disease Link Frequency Relevance Heat
Virus Diseases 94 100.00 Very High Very High Very High
Disease 5 99.36 Very High Very High Very High
Morphine Dependence 4 98.44 Very High Very High Very High
Neurodegenerative Disease 2 98.24 Very High Very High Very High
Cognitive Disorder 3 92.72 High High
Targeted Disruption 2 91.32 High High
Sprains And Strains 3 76.16 Quite High
Infection 20 72.88 Quite High
Borna Disease 5 50.00 Quite Low
Congenital Anomalies 1 10.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether chronic morphine or clonidine treatment alters spinal PKC activity, the present studies measured PKC activity and expression of PKC isoform proteins in spinal cord cytosol and membrane fractions.
Regulation (measured) of Regulation (activity) of PKC in spinal cord associated with kinase c, spinal cord, clonidine and morphine
1) Confidence 0.45 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10424770 Disease Relevance 0 Pain Relevance 2.07
[Effects of chronic morphine treatment on inositol phosphates contents and PKC activity in mouse brain].
Regulation ([Effects) of Regulation (contents) of PKC in brain associated with morphine
2) Confidence 0.45 Published 1998 Journal Yao Xue Xue Bao Section Title Doc Link 12016940 Disease Relevance 0.26 Pain Relevance 0.90
Thus, changes in PKC signaling and in presynaptic potentiation observed in BDV-infected neurons could critically affect learning and behavior.
Regulation (affect) of Regulation (changes) of PKC in neurons associated with virus diseases and kinase c
3) Confidence 0.36 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 1.08 Pain Relevance 0.49

General Comments

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