INT83212

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Context Info
Confidence 0.55
First Reported 1999
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 17.53
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Mki67) nucleolus (Mki67) nucleus (Mki67)
intracellular (Mki67) cytoplasm (Mki67)
Anatomy Link Frequency
liver 6
RG2 4
brain 2
F4/80 2
Mki67 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 39 97.96 Very High Very High Very High
Chronic pancreatitis 2 84.48 Quite High
palliative 5 56.72 Quite High
positron emission tomography 47 55.12 Quite High
Pain 6 30.64 Quite Low
abdominal pain 8 23.24 Low Low
cINOD 3 18.80 Low Low
cva 7 13.12 Low Low
pain pelvic 1 7.40 Low Low
imagery 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 995 100.00 Very High Very High Very High
Pancreatic Cancer 15 100.00 Very High Very High Very High
Breast Cancer 255 99.98 Very High Very High Very High
Apoptosis 185 99.84 Very High Very High Very High
Chondrosarcoma 19 99.40 Very High Very High Very High
Malignant Neoplastic Disease 103 99.20 Very High Very High Very High
Recurrence 47 98.80 Very High Very High Very High
Fibrosarcoma 27 98.64 Very High Very High Very High
Granular Cell Tumor 24 98.52 Very High Very High Very High
INFLAMMATION 38 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of Ki67 was 21% increased at Day 5 (P?
Positive_regulation (increased) of Gene_expression (Expression) of Ki67
1) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0 Pain Relevance 0.03
We did not observe increased Ki67 expression when MYC was overexpressed in the adult liver (Figure 6E and 6H versus 6D and 6G).
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of Ki67 in liver
2) Confidence 0.50 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.16 Pain Relevance 0
We did not observe increased Ki67 expression when MYC was overexpressed in the adult liver (Figure 6E and 6H versus 6D and 6G).
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of Ki67 in liver
3) Confidence 0.36 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.16 Pain Relevance 0
We did not observe increased Ki67 expression when MYC was overexpressed in the adult liver (Figure 6E and 6H versus 6D and 6G).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Ki67 in liver
4) Confidence 0.36 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.16 Pain Relevance 0
Compared to the control group, high levels—though not statistically significant—of glucose transporter-1, HK II, and Ki67 expression were found at the end of treatment in both FDG and FLT groups.
Neg (not) Positive_regulation (levels) of Gene_expression (expression) of Ki67
5) Confidence 0.32 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 0.62 Pain Relevance 0.05
Furthermore, high levels of Ki67 (MIB-1) expression were consistent with a malignant diagnosis, despite a low visual mitotic rate that was also observed.
Positive_regulation (levels) of Gene_expression (expression) of Ki67 associated with malignant neoplastic disease
6) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2984427 Disease Relevance 1.13 Pain Relevance 0
When probed for the expression of p27Kip1 and Ki67 proteins, mock and SV-treated brain sections showed very little expression of p27Kip1 and increased expression of Ki67.
Positive_regulation (increased) of Gene_expression (expression) of Ki67 in brain
7) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.71 Pain Relevance 0
In the multivariate analysis the Ki-67 staining was the most important determinant of long-term survival (p=0.005). c-jun and Ki-67 are overexpressed in pancreatic carcinoma, but only Ki-67 is a strong predictive factor.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Ki-67 associated with pancreatic cancer
8) Confidence 0.26 Published 1999 Journal Oncol. Rep. Section Abstract Doc Link 10425312 Disease Relevance 0.85 Pain Relevance 0.06
The expression of c-jun and Ki-67 in pancreatic cancer and their relation with tumour histological features and patients survival were evaluated.
Positive_regulation (evaluated) of Gene_expression (expression) of Ki-67 associated with cancer and pancreatic cancer
9) Confidence 0.26 Published 1999 Journal Oncol. Rep. Section Abstract Doc Link 10425312 Disease Relevance 0.86 Pain Relevance 0.08
Immunhistochemistry revealed increased expression of Ki-67, ?
Positive_regulation (increased) of Gene_expression (expression) of Ki-67
10) Confidence 0.24 Published 2010 Journal Journal of Carcinogenesis Section Abstract Doc Link PMC2862504 Disease Relevance 1.00 Pain Relevance 0.08
We therefore analyzed the effect of irradiation on cell cycle by measuring Ki67 expression and 7AAD staining by multiparameter flow cytometry [14].
Positive_regulation (measuring) of Gene_expression (expression) of Ki67
11) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.61 Pain Relevance 0
Endocrine and exocrine elements were identified by immunostaining for insulin (as a marker for endocrine expression) or for trypsin and amylase (markers of exocrine expression); both types of cells were also stained for expression of Ki67 (a proliferation marker).
Positive_regulation (stained) of Gene_expression (expression) of Ki67
12) Confidence 0.21 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1479387 Disease Relevance 0.05 Pain Relevance 0.03
On multivariate analysis for overall survival, both pre- and excision Ki67 expression was significant independent predictors, but the latter showed a stronger prognostic impact.
Positive_regulation (excision) of Gene_expression (expression) of Ki67
13) Confidence 0.20 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.60 Pain Relevance 0
A strong correlation has been noted between the percentage of cells positive for Ki67 and the nuclear grade, age, and mitotic rate.16,17 Multiple studies have indicated that breast cancer overexpress Ki67 in more than 20–50% of the cells are at high risk of developing recurrent disease, showing a statistically significant correlation with clinical outcome, such as disease-free survival or overall survival.18–30
Positive_regulation (overexpress) of Gene_expression (overexpress) of Ki67 associated with breast cancer and disease
14) Confidence 0.20 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.82 Pain Relevance 0
Increased expression of p53 and an elevated Ki-67 expression in the tumor cells further supported the diagnosis.
Positive_regulation (elevated) of Gene_expression (expression) of Ki-67 associated with cancer
15) Confidence 0.17 Published 2003 Journal World J Surg Oncol Section Body Doc Link PMC272934 Disease Relevance 2.16 Pain Relevance 0
Increased expression of cell cycle markers (MIB-I or Ki-67) have been linked to a less favorable prognosis in larger studies [30].
Positive_regulation (Increased) of Gene_expression (expression) of Ki-67
16) Confidence 0.16 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 1.00 Pain Relevance 0
Serial sections were immunostained with antibodies for Ki-67 (DakoCytomation), F4/80 (Serotec), unphosphorylated (activated) ?
Positive_regulation (activated) of Gene_expression (antibodies) of Ki-67 in F4/80
17) Confidence 0.09 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.14 Pain Relevance 0
More recently, molecular markers such as Ki-67 and p53 overexpression have been linked to a higher recurrence risk and poor survival [15].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Ki-67 associated with recurrence
18) Confidence 0.07 Published 2004 Journal Int Semin Surg Oncol Section Body Doc Link PMC483034 Disease Relevance 1.65 Pain Relevance 0.06
The immunohistochemistry results on day 16 after BP treatment showed a decrease in Ki-67 protein expression, an increase in cleaved caspase 3 protein expression and an increase in apoptosis in tumor cells relative to the control group in vivo (Fig. 4c); these results are similar to those shown in the subcutaneous RG2 tumor model.
Positive_regulation (increase) of Gene_expression (expression) of Ki-67 in RG2 associated with cancer and apoptosis
19) Confidence 0.06 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 1.64 Pain Relevance 0
The immunohistochemistry results on day 16 after BP treatment showed a decrease in Ki-67 protein expression, an increase in cleaved caspase 3 protein expression and an increase in apoptosis in tumor cells relative to the control group in vivo (Fig. 4c); these results are similar to those shown in the subcutaneous RG2 tumor model.
Positive_regulation (increase) of Gene_expression (expression) of Ki-67 in RG2 associated with cancer and apoptosis
20) Confidence 0.06 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 1.62 Pain Relevance 0

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