INT83229

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Context Info
Confidence 0.45
First Reported 1999
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 4.62
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
sciatic nerve 2
striatum 2
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 213 100.00 Very High Very High Very High
Sciatic nerve 71 99.84 Very High Very High Very High
antidepressant 4 99.30 Very High Very High Very High
Spinal cord 91 93.32 High High
depression 9 82.04 Quite High
Hippocampus 62 78.92 Quite High
fluoxetine 2 77.36 Quite High
Desipramine 1 76.40 Quite High
Neuropathic pain 2 72.88 Quite High
addiction 7 55.60 Quite High
Disease Link Frequency Relevance Heat
Stress 192 99.98 Very High Very High Very High
Nervous System Injury 12 99.98 Very High Very High Very High
Contusions 5 97.96 Very High Very High Very High
Injury 38 97.56 Very High Very High Very High
Mental Disorders 12 95.04 Very High Very High Very High
Paralysis 2 92.96 High High
Aids-related Complex 6 90.28 High High
Disease 25 89.88 High High
Neurodegenerative Disease 4 88.20 High High
Death 10 86.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to test the hypothesis that the previously shown biphasic action by the antidepressant drugs on total BDNF expression is explained by differential BDNF transcript regulation.
Regulation (explained) of Regulation (regulation) of BDNF associated with antidepressant
1) Confidence 0.45 Published 2006 Journal Brain Res. Section Abstract Doc Link 16842762 Disease Relevance 0.08 Pain Relevance 0.34
Although BDNF mRNA in cortical dendrites will not reach the striatum, changes in cortical BDNF levels could affect survival of striatal cells.
Regulation (affect) of Regulation (changes) of BDNF in striatum
2) Confidence 0.38 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.59 Pain Relevance 0
Effects of exogenous BDNF injected into the footpad on the locomotion recovery after contusion injury
Regulation (injected) of Regulation (Effects) of BDNF associated with injury, contusions and bdmf
3) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.92 Pain Relevance 0.21
In addition, we examined the influence of transcriptional changes on BDNF protein levels.
Spec (examined) Regulation (influence) of Spec (examined) Regulation (changes) of BDNF
4) Confidence 0.27 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.72 Pain Relevance 0.11
Further studies examining whether stress affects other epigenetic pathways involved in regulation of the BDNF gene, such as DNA methylation, may provide additional valuable information regarding the pathophysiology of stress-related mental disorders.


Spec (whether) Regulation (affects) of Regulation (regulation) of BDNF associated with mental disorders and stress
5) Confidence 0.27 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.99 Pain Relevance 0
Further studies examining whether stress affects other epigenetic pathways involved in regulation of the BDNF gene, such as DNA methylation, may provide additional valuable information regarding the pathophysiology of stress-related mental disorders.


Regulation (involved) of Regulation (regulation) of BDNF associated with mental disorders and stress
6) Confidence 0.27 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.99 Pain Relevance 0
These studies indicate that sciatic nerve injury results in a differential regulation of brain-derived neurotrophic factor in different subpopulations of sensory neurons in the dorsal root ganglia.
Regulation (results) of Regulation (regulation) of brain-derived neurotrophic factor in sciatic nerve associated with nervous system injury and sciatic nerve
7) Confidence 0.23 Published 1999 Journal Neuroscience Section Abstract Doc Link 10426526 Disease Relevance 0.23 Pain Relevance 0.23
These results indicate gene-specific roles for PI3K, NOS, and CAMK in the modulation of striatal BDNF responses in concert with necessary activation of MEK and ERK.


Regulation (roles) of Regulation (modulation) of BDNF
8) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

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