INT83230

Context Info Confidence 0.35 First Reported 1999 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.29 Pain Relevance 0.23

cytosol (Prf1) endosome (Prf1) extracellular region (Prf1) cytoplasmic membrane-bounded vesicle (Prf1) plasma membrane (Prf1) molecular_function (Prf1)

Anatomy Link Frequency corpus callosum 1 vertex 1 Prf1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat GABAergic 2 72.56 agonist 2 71.76 Clonidine 3 66.48 antagonist 1 48.48 hyperexcitability 1 5.00 ketamine 1 5.00 ischemia 1 5.00 Pain 1 5.00 cva 1 5.00

Disease Link Frequency Relevance Heat Anxiety Disorder 2 95.60 Injury 20 64.40 Dyslexia 3 5.00 Pain 1 5.00 Congenital Anomalies 1 5.00 Cognitive Disorder 1 5.00 Cv Unclassified Under Development 1 5.00 Hemorrhage 1 5.00 Brain Injury 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Importantly, subjects with the largest reduction in corpus callosum volume (P1 lesion group), as seen in the current analysis, showed the worst long-term behavioral outcome [1].

Negative_regulation (reduction) of P1 in corpus callosum

1) Confidence 0.35 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2204005 Disease Relevance 0.29 Pain Relevance 0

Previous studies have shown that the vertex-recorded P13 auditory evoked potential in the rat appears to be the rodent equivalent of the human P1 (or P50) potential.

Negative_regulation (equivalent) of P1 in vertex

2) Confidence 0.15 Published 1999 Journal Neuroscience Section Abstract Doc Link 10426532 Disease Relevance 0 Pain Relevance 0.23

General Comments

This test has worked.