INT83243

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2006
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 1.50
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
placenta 3
lung 1
SLC45A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 69.44 Quite High
Inflammation 2 68.96 Quite High
Nicotine 6 35.36 Quite Low
analgesia 2 25.00 Low Low
beta blocker 2 25.00 Low Low
fortral 2 25.00 Low Low
Opioid 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 26 99.60 Very High Very High Very High
Cancer 2 95.04 Very High Very High Very High
Liver Cancer 2 91.56 High High
Lung Cancer 2 80.96 Quite High
INFLAMMATION 2 68.96 Quite High
Thrombosis 2 25.00 Low Low
Sleep Disorders 2 25.00 Low Low
Increased Venous Pressure Under Development 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in CYP 1A1 mRNA induced by sulindac was, like enzyme activity, sustained for several days after the initial treatment.
Positive_regulation (increase) of Positive_regulation (induced) of 1A1
1) Confidence 0.67 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16531450 Disease Relevance 0.16 Pain Relevance 0.10
Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta.
Spec (possibly) Positive_regulation (responsible) of Spec (possibly) Positive_regulation (induction) of 1A1 in placenta associated with nicotine addiction
2) Confidence 0.45 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.59 Pain Relevance 0
The increase in CYP 1A1 mRNA induced by sulindac was, like enzyme activity, sustained for several days after the initial treatment.
Positive_regulation (induced) of Positive_regulation (increase) of 1A1
3) Confidence 0.45 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16531450 Disease Relevance 0.16 Pain Relevance 0.10
Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta.
Spec (possibly) Positive_regulation (responsible) of in lung Spec (possibly) Positive_regulation (induction) of 1A1 in placenta associated with nicotine addiction
4) Confidence 0.15 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.59 Pain Relevance 0

General Comments

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