INT83246

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Context Info
Confidence 0.44
First Reported 1999
Last Reported 2002
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.61
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PPIG) protein folding (PPIG) nucleoplasm (PPIG)
nucleolus (PPIG) nucleus (PPIG) cytoplasm (PPIG)
Anatomy Link Frequency
placenta 3
lung 1
PPIG (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 4 94.80 High High
methotrexate 1 92.36 High High
cINOD 1 91.68 High High
Analgesic 1 90.16 High High
Leflunomide 10 88.88 High High
Nicotine 6 34.96 Quite Low
beta blocker 2 25.00 Low Low
analgesia 2 25.00 Low Low
fortral 2 25.00 Low Low
Opioid 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 26 99.60 Very High Very High Very High
Cancer 2 95.04 Very High Very High Very High
Rheumatoid Arthritis 4 94.80 High High
INFLAMMATION 1 91.44 High High
Lung Cancer 2 80.56 Quite High
Autoimmune Disease 1 73.28 Quite High
Disease 1 52.00 Quite High
Thrombosis 2 25.00 Low Low
Sleep Disorders 2 25.00 Low Low
Increased Venous Pressure Under Development 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta.
Spec (possibly) Regulation (responsible) of Spec (possibly) Positive_regulation (induction) of CYP in placenta associated with nicotine addiction
1) Confidence 0.44 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.59 Pain Relevance 0
Nonspecific inducers of cytochrome P450 (CYP) and some drugs metabolised by CYP2C9 affect the metabolism of M1, and caution should be used in patients cotreated with them.
Regulation (affect) of Positive_regulation (inducers) of CYP
2) Confidence 0.24 Published 2002 Journal Clin Pharmacokinet Section Abstract Doc Link 12074690 Disease Relevance 0.43 Pain Relevance 0.72
Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta.
Spec (possibly) Regulation (responsible) of in lung Spec (possibly) Positive_regulation (induction) of CYP in placenta associated with nicotine addiction
3) Confidence 0.15 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.59 Pain Relevance 0

General Comments

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