INT83247

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2006
Negated 0
Speculated 3
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 1.81
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
1A6 1
liver 1
1A2 1
lung 1
placenta 1
SLC45A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 19 98.60 Very High Very High Very High
Kinase C 2 86.24 High High
cINOD 8 75.00 Quite High
Inflammation 3 71.52 Quite High
aspirin 1 55.28 Quite High
Morphine 2 41.44 Quite Low
Nicotine 6 35.36 Quite Low
beta blocker 2 25.00 Low Low
analgesia 2 25.00 Low Low
fortral 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 26 99.20 Very High Very High Very High
Cancer 2 94.24 High High
Liver Cancer 3 94.12 High High
Lung Cancer 2 80.96 Quite High
INFLAMMATION 5 75.00 Quite High
Hepatotoxicity 2 75.00 Quite High
Toxicity 3 25.00 Low Low
Thrombosis 2 25.00 Low Low
Sleep Disorders 2 25.00 Low Low
Increased Venous Pressure Under Development 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta.
Spec (possibly) Positive_regulation (induction) of 1A1 in placenta associated with nicotine addiction
1) Confidence 0.67 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.59 Pain Relevance 0
The increase in CYP 1A1 mRNA induced by sulindac was, like enzyme activity, sustained for several days after the initial treatment.
Positive_regulation (increase) of 1A1
2) Confidence 0.67 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16531450 Disease Relevance 0.16 Pain Relevance 0.10
Sulindac treatment resulted in a profound, dose-dependent increase in CYP 1A1 mRNA and a modest increase in 1A2 mRNA.
Positive_regulation (increase) of 1A1 in 1A2
3) Confidence 0.67 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16531450 Disease Relevance 0.17 Pain Relevance 0.11
The increase in CYP 1A1 mRNA induced by sulindac was, like enzyme activity, sustained for several days after the initial treatment.
Positive_regulation (induced) of 1A1
4) Confidence 0.67 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16531450 Disease Relevance 0.16 Pain Relevance 0.10
In summary, our results suggest gastrointestinally distributed UGT1A10 is important for detoxifying estrogens/phytoestrogens and aromatic acids with complementary activity by UGT1A7, -1A8, -1A3, and/or -1A1 evidently dependent upon phosphorylation.
Spec (evidently) Positive_regulation (dependent) of 1A1
5) Confidence 0.49 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15117964 Disease Relevance 0.07 Pain Relevance 0.18
The importance of uridine 5'-diphosphate-glucuronosyltranferases (UGT) 2B15 and other UGT enzymes (1A1, 1A6, and 1A9) in glucuronidating acetaminophen (APAP) is demonstrated.
Positive_regulation (importance) of 1A1 in 1A6 associated with paracetamol
6) Confidence 0.49 Published 2006 Journal Chem. Res. Toxicol. Section Abstract Doc Link 16696573 Disease Relevance 0.07 Pain Relevance 0.69
Previous results demonstrating homotropic activation of human UDP-glucuronosyltransferase (UGT) 1A1-catalyzed estradiol-3-glucuronidation led us to investigate the effects of 16 compounds on estradiol glucuronidation by human liver microsomes (HLM).
Positive_regulation (activation) of 1A1 in liver
7) Confidence 0.45 Published 2002 Journal Drug Metab. Dispos. Section Abstract Doc Link 12386134 Disease Relevance 0 Pain Relevance 0
Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta.
Spec (possibly) Positive_regulation (induction) of 1A1 in lung associated with nicotine addiction
8) Confidence 0.23 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.59 Pain Relevance 0

General Comments

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