INT83252

Context Info Confidence 0.43 First Reported 1999 Last Reported 1999 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 4 Disease Relevance 1.00 Pain Relevance 0.35

kinase activity (Git1) cytoplasm (Git1)

Git1 (Mus musculus)

Pain Link Frequency Relevance Heat qutenza 10 94.48

Disease Link Frequency Relevance Heat Ileus 16 99.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is worthy to study their therapeutical effect in the prevention of the inhibition of GIT, including ileus, in clinic.

Negative_regulation (prevention) of Negative_regulation (inhibition) of GIT associated with ileus

1) Confidence 0.43 Published 1999 Journal Bioorg. Med. Chem. Section Abstract Doc Link 10428392 Disease Relevance 0.17 Pain Relevance 0.18

On the other hand, oleanolic acid 28-O-monodesmoside (compound O (2, 50 mg/kg)) significantly inhibited GIT. 4 (5-25 mg/kg) and 6 (12.5 and 25 mg/kg) also significantly prevented the inhibition of GIT induced by the peritoneal injection of acetic acid. 2 and 9 (50 mg/kg) significantly potentiated the inhibition of GIT, whereas 1, 3, 5, 7, 8, and 10 (50 mg/kg) showed no significant effect. 3, 4, 6, and 10 (50 mg/kg) significantly prevented the inhibition of GIT induced by laparotomy with manipulation, while 1, 2, 5, 7, 8, and 9 (50 mg/kg) showed no significant effect.

Negative_regulation (prevented) of Negative_regulation (inhibition) of GIT

2) Confidence 0.38 Published 1999 Journal Bioorg. Med. Chem. Section Abstract Doc Link 10428392 Disease Relevance 0.21 Pain Relevance 0

They (12.5-100mg/kg) also dose-dependently prevented the inhibition of GIT induced by the laparotomy with manipulation.

Negative_regulation (prevented) of Negative_regulation (inhibition) of GIT

3) Confidence 0.36 Published 1999 Journal Bioorg. Med. Chem. Section Abstract Doc Link 10482465 Disease Relevance 0.30 Pain Relevance 0.11

The fraction (12.5-100 mg/ kg) and 1-4 (12.5-50 mg/kg, except for 1 and 2 at 12.5 mg/kg) dose-dependently prevented the inhibition of GIT induced by the acetic acid peritoneal irritation.

Negative_regulation (prevented) of Negative_regulation (inhibition) of GIT

4) Confidence 0.36 Published 1999 Journal Bioorg. Med. Chem. Section Abstract Doc Link 10482465 Disease Relevance 0.30 Pain Relevance 0.05

General Comments

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