INT83253

Context Info Confidence 0.41 First Reported 1999 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 1.40 Pain Relevance 0.87

kinase activity (Git1) cytoplasm (Git1)

Anatomy Link Frequency sensory nerves 2 Git1 (Mus musculus)

Pain Link Frequency Relevance Heat qutenza 13 99.08 Clonidine 2 88.88

Disease Link Frequency Relevance Heat Ileus 24 98.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results suggest that sympathetic nervous system, but not capsaicin-sensitive sensory nerves, be involved in the enhancements of GIT by 3, 4, and 6.

Positive_regulation (enhancements) of GIT in sensory nerves associated with qutenza

1) Confidence 0.41 Published 1999 Journal Bioorg. Med. Chem. Section Abstract Doc Link 10428392 Disease Relevance 0.07 Pain Relevance 0.19

The increase in the GIT ranged from 4 to 22%.

Positive_regulation (increase) of GIT

2) Confidence 0.40 Published 2003 Journal Food Chem. Toxicol. Section Abstract Doc Link 12453726 Disease Relevance 0 Pain Relevance 0.17

These results imply that the sympathetic nervous system may be, but neither capsaicin-sensitive sensory nerves nor the cholinergic mechanism, involved in the accelerations of GIT by escins 1-4.

Positive_regulation (accelerations) of GIT in sensory nerves associated with qutenza

3) Confidence 0.39 Published 1999 Journal Bioorg. Med. Chem. Section Abstract Doc Link 10482465 Disease Relevance 0.16 Pain Relevance 0.19

These results demonstrated that the saponin fraction and 1-4 accelerated GIT and prevented the experimental ileus, and indicate that the 21, 22-acyl groups are essential for the accelerative effects of 1-4.

Positive_regulation (accelerated) of GIT associated with ileus

4) Confidence 0.39 Published 1999 Journal Bioorg. Med. Chem. Section Abstract Doc Link 10482465 Disease Relevance 0.30 Pain Relevance 0.14

They (12.5-100mg/kg) also dose-dependently prevented the inhibition of GIT induced by the laparotomy with manipulation.

Positive_regulation (induced) of GIT

5) Confidence 0.39 Published 1999 Journal Bioorg. Med. Chem. Section Abstract Doc Link 10482465 Disease Relevance 0.30 Pain Relevance 0.12

The fraction (12.5-100 mg/ kg) and 1-4 (12.5-50 mg/kg, except for 1 and 2 at 12.5 mg/kg) dose-dependently prevented the inhibition of GIT induced by the acetic acid peritoneal irritation.

Positive_regulation (induced) of GIT

6) Confidence 0.39 Published 1999 Journal Bioorg. Med. Chem. Section Abstract Doc Link 10482465 Disease Relevance 0.30 Pain Relevance 0.05

One hour after the oral administration, the saponin fraction (12.5-100 mg/kg) and 14 (12.5-50 mg/ kg, except for 3 at 12.5 mg/kg) dose-dependently accelerated GIT.

Positive_regulation (accelerated) of GIT

7) Confidence 0.39 Published 1999 Journal Bioorg. Med. Chem. Section Abstract Doc Link 10482465 Disease Relevance 0.26 Pain Relevance 0

General Comments

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