INT83273

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Context Info
Confidence 0.34
First Reported 1999
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 12
Disease Relevance 6.95
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itga2b)
Anatomy Link Frequency
platelets 10
body 1
Itga2b (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 3 90.72 High High
antagonist 2 75.00 Quite High
agonist 45 68.88 Quite High
anesthesia 27 5.40 Low Low
cytokine 27 5.00 Very Low Very Low Very Low
Inflammation 27 5.00 Very Low Very Low Very Low
ketamine 9 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis 309 99.74 Very High Very High Very High
Hypothermia 414 99.58 Very High Very High Very High
Infarction 1 99.00 Very High Very High Very High
Cancer 24 98.00 Very High Very High Very High
Metastasis 2 95.32 Very High Very High Very High
Myocardial Infarction 5 94.36 High High
Endotoxemia 189 93.48 High High
Adhesions 74 91.92 High High
Death 1 91.88 High High
Recurrence 1 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cell types that express integrins GPIIb/IIIa and a av b b3 such as platelets, endothelial and tumor cells have been implicated in angiogenesis, tumor growth and metastasis.
Gene_expression (express) of GPIIb/IIIa in platelets associated with cancer and metastasis
1) Confidence 0.34 Published 2000 Journal Pathol. Oncol. Res. Section Abstract Doc Link 11033455 Disease Relevance 0.71 Pain Relevance 0.12
Cell types that express integrins GPIIb/IIIa and a av b b3 such as platelets, endothelial and tumor cells have been implicated in angiogenesis, tumor growth and metastasis.
Gene_expression (express) of GPIIb/IIIa in platelets associated with cancer and metastasis
2) Confidence 0.29 Published 2000 Journal Pathol. Oncol. Res. Section Abstract Doc Link 11033455 Disease Relevance 0.71 Pain Relevance 0.12
Captopril administration reduces thrombus formation and surface expression of platelet glycoprotein IIb/IIa in early postmyocardial infarction stage.
Gene_expression (expression) of platelet glycoprotein IIb/IIa in platelet associated with infarction and thrombosis
3) Confidence 0.15 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Title Doc Link 10428581 Disease Relevance 0.83 Pain Relevance 0.09
Because concomitant systemic hypothermia also did not affect GPIIb-IIIa expression, our data suggest that platelet expression of this molecule did not substantively contribute to low temperature-induced acceleration of thrombus formation during endotoxemia.
Gene_expression (expression) of GPIIb-IIIa in platelet associated with endotoxemia, hypothermia and thrombosis
4) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.84 Pain Relevance 0.05
Flow cytometric analysis of P-selectin, glycoprotein IIb-IIIa and CD107a expression
Gene_expression (expression) of glycoprotein IIb-IIIa
5) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0 Pain Relevance 0
However, hypothermic incubation of the LPS-exposed platelets at 34°C and 31°C did not further affect the P-selectin, GPIIb-IIIa and CD107a expression (data not shown).


Gene_expression (expression) of GPIIb-IIIa in platelets
6) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.13 Pain Relevance 0
Of interest, spontaneous platelet GPIIb-IIIa expression did not increase but even slightly decreased after endotoxin exposure, and thrombin-stimulation of endotoxin-exposed platelets also induced an only slight but not significant elevation of expression.
Gene_expression (expression) of GPIIb-IIIa in platelets
7) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.87 Pain Relevance 0.07
In platelets of saline controls (37°C), in vitro stimulation with thrombin resulted in elevated expression of P-selectin, GPIIb-IIIa and CD107a.
Gene_expression (expression) of GPIIb-IIIa in platelets
8) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.33 Pain Relevance 0
In vivo LPS exposure did not significantly affect spontaneous platelet expression of P-selectin, GPIIb-IIIa and CD107a.
Gene_expression (expression) of GPIIb-IIIa in platelet
9) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.52 Pain Relevance 0
Also, incubation of platelets from LPS-exposed animals at temperatures of 34°C and 31°C did not result in significant changes in spontaneous P-selectin, GPIIb-IIIa and CD107a expression (data not shown).
Gene_expression (expression) of GPIIb-IIIa in platelets
10) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.46 Pain Relevance 0
Flow cytometric analysis of murine platelet P-selectin, glycoprotein IIb-IIIa and CD107a expression
Gene_expression (expression) of glycoprotein IIb-IIIa in platelet
11) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.62 Pain Relevance 0
Of interest, this hypothermia-induced modulation towards a more procoagulant state is not based on increased expression and release of P-selectin, E-selectin, ICAM-1, VCAM-1 and GPIIb-IIIa because tissue expression and plasma levels of these markers were not affected by the reduction of the core body temperature to 34°C or 31°C.
Gene_expression (expression) of GPIIb-IIIa in body associated with hypothermia
12) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.93 Pain Relevance 0

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