INT83287

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Context Info
Confidence 0.46
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.74
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PPIG) protein folding (PPIG) nucleoplasm (PPIG)
nucleolus (PPIG) nucleus (PPIG) cytoplasm (PPIG)
PPIG (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 4 95.32 Very High Very High Very High
Bile 2 77.20 Quite High
antagonist 8 43.68 Quite Low
Analgesic 1 10.00 Low Low
Inflammation 34 5.00 Very Low Very Low Very Low
Potency 13 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 181 99.24 Very High Very High Very High
Cancer 122 98.12 Very High Very High Very High
Metastasis 3 95.00 High High
Carcinoma 3 93.72 High High
Hepatotoxicity 14 79.92 Quite High
Adhesions 1 72.24 Quite High
Stress 2 30.20 Quite Low
Hypoxia 4 17.64 Low Low
Glioma 1 14.80 Low Low
INFLAMMATION 34 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Zanamivir had no effect on the expression of microsomal CYP isoenzymes after daily intravenous treatment of rats with zanamivir 1, 9 or 90 mg/kg for 5 weeks.
Neg (no) Regulation (effect) of Gene_expression (expression) of CYP
1) Confidence 0.46 Published 1999 Journal Clin Pharmacokinet Section Body Doc Link 10429839 Disease Relevance 0 Pain Relevance 0
The cytotoxicity depended on the expression of CYP subtypes and increased in a dose-dependent manner.
Regulation (depended) of Gene_expression (expression) of CYP
2) Confidence 0.39 Published 2001 Journal Toxicol In Vitro Section Abstract Doc Link 11377097 Disease Relevance 0 Pain Relevance 0.28
It also provides information on CYP induction, an important parameter used to assess a compounds potential for causing DDIs.
Regulation (information) of Gene_expression (induction) of CYP
3) Confidence 0.05 Published 2010 Journal Combinatorial Chemistry & High Throughput Screening Section Body Doc Link PMC2908937 Disease Relevance 0.31 Pain Relevance 0.07
Subsequent studies, in which CYP epoxygenase levels were manipulated, by either overexpression of CYP2J2 or antisense in the xenotransplanted tumor cell, suggest EETs may play a role in cancer metastasis [121].
Regulation (manipulated) of Gene_expression (levels) of CYP associated with cancer and metastasis
4) Confidence 0.03 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.42 Pain Relevance 0

General Comments

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