INT83290

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 9.06
Pain Relevance 5.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2)
cytoskeleton organization (Ccl2) cytoplasm (Ccl2)
Anatomy Link Frequency
monocyte 6
acinar cells 4
macrophage 2
CCI 2
PSCs 2
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 28 100.00 Very High Very High Very High
Inflammation 104 99.64 Very High Very High Very High
acular 2 99.24 Very High Very High Very High
Spinal cord 6 97.68 Very High Very High Very High
IPN 2 97.68 Very High Very High Very High
Neuropathic pain 2 97.60 Very High Very High Very High
Eae 1 97.08 Very High Very High Very High
Chronic pancreatitis 10 96.00 Very High Very High Very High
Sciatic nerve 10 95.68 Very High Very High Very High
Pain 6 95.00 High High
Disease Link Frequency Relevance Heat
Hypertension 52 100.00 Very High Very High Very High
Necrosis 5 100.00 Very High Very High Very High
Cancer 5 100.00 Very High Very High Very High
INFLAMMATION 126 99.64 Very High Very High Very High
Syndrome 3 98.28 Very High Very High Very High
Status Epilepticus 106 97.96 Very High Very High Very High
Diabetes Mellitus 58 97.96 Very High Very High Very High
Inflammatory Pain 2 97.68 Very High Very High Very High
Neuropathic Pain 5 97.60 Very High Very High Very High
Injury 16 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thereafter, the effect of CM on monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) production from monocytes was examined.
Spec (examined) Regulation (effect) of Gene_expression (production) of MCP-1 in monocyte associated with necrosis and cancer
1) Confidence 0.59 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 15531908 Disease Relevance 0.83 Pain Relevance 0.41
Subsequently, cultured rat PSCs were exposed to CM and tested to see whether their proliferation, MCP-1 production and procollagen alpha1 messenger RNA expression was influenced by CM.
Spec (whether) Regulation (influenced) of Gene_expression (production) of MCP-1 in PSCs
2) Confidence 0.59 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 15531908 Disease Relevance 0.81 Pain Relevance 0.41
Further elucidation of the regulation and coordination of MIP-1alpha and MCP-1 production may lead to new therapeutic approaches to GBS in humans.
Regulation (regulation) of Gene_expression (production) of MCP-1 associated with syndrome
3) Confidence 0.43 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10430050 Disease Relevance 1.24 Pain Relevance 1.17
Thereafter, the effect of CM on monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) production from monocytes was examined.
Spec (examined) Regulation (effect) of Gene_expression (production) of monocyte chemoattractant protein-1 in monocyte associated with necrosis and cancer
4) Confidence 0.38 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 15531908 Disease Relevance 0.83 Pain Relevance 0.41
Prostaglandin E2 modulates TNF-alpha-induced MCP-1 synthesis in pancreatic acinar cells in a PKA-dependent manner.
Regulation (modulates) of Gene_expression (synthesis) of MCP-1 in acinar cells
5) Confidence 0.34 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 17916652 Disease Relevance 0.59 Pain Relevance 0.35
PGE(2) modulates the TNF-alpha-induced MCP-1 synthesis and secretion from acinar cells.
Regulation (modulates) of Gene_expression (synthesis) of MCP-1 in acinar cells
6) Confidence 0.25 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17916652 Disease Relevance 0.30 Pain Relevance 0.16
In our study, the effect of hypertension on MCP-1 and osteopontin expression as well as on macrophage infiltration was much more prominent than the effects of diabetes mellitus.
Regulation (effect) of Gene_expression (expression) of MCP-1 in macrophage associated with diabetes mellitus and hypertension
7) Confidence 0.25 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.19 Pain Relevance 0.04
The targeted blockade of JAK/STAT3 activity prevented the abnormal expression of IL-6, CC chemokine ligand CCL2, and activating transcription factor ATF3 induced in the spinal cord by chronic constriction injury of the sciatic nerve (CCI) and substantially attenuated mechanical hypersensitivity (allodynia) in rats.
Regulation (abnormal) of Gene_expression (expression) of CCL2 in CCI associated with chemokine, allodynia, eae, hypersensitivity, injury, sciatic nerve and spinal cord
8) Confidence 0.20 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20410127 Disease Relevance 0.79 Pain Relevance 1.10
In OxATP-infused animals, changes in MCP-1 expression were similar to those in saline-infused animals (Figures 7C1-3), while the number of MCP-1-immunoreactive microglia in this group was smaller (but not significantly) than that in saline-infused animals (Figure 7E).
Regulation (changes) of Gene_expression (expression) of MCP-1 in microglia
9) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.92 Pain Relevance 0
However, ketorolac treatment did not have a significant effect on the gene expression of IL-6, IL-8, CCL2, CXCL2 and ANXA1 at the same time point of acute inflammation.
Regulation (effect) of Gene_expression (expression) of CCL2 associated with inflammation and acular
10) Confidence 0.14 Published 2009 Journal Pain Section Abstract Doc Link 19233564 Disease Relevance 1.22 Pain Relevance 1.22
In addition, inhibition of endogenous NO synthesis by L-NNA increased endothelial MCP-1 mRNA expression and resulted in a marked increase in monocyte chemotactic activity [57], suggesting that NO modulates MCP-1 expression and activity in vitro.
Regulation (modulates) of Gene_expression (expression) of MCP-1 in monocyte
11) Confidence 0.11 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.34 Pain Relevance 0.28

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