INT83295

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Context Info
Confidence 0.39
First Reported 1999
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 14.55
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
histiocytes 4
plasmacytoid monocytes 1
accessory cells 1
monocytes 1
microglia 1
Cd68 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 40 99.92 Very High Very High Very High
fibrosis 1 94.68 High High
cytokine 27 89.04 High High
tolerance 16 88.88 High High
Central nervous system 12 87.00 High High
headache 2 86.68 High High
Bile 3 85.20 High High
abdominal pain 5 83.60 Quite High
ischemia 6 83.20 Quite High
Dismenorea 1 82.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 39 99.92 Very High Very High Very High
Cancer 54 99.58 Very High Very High Very High
Disease 92 99.56 Very High Very High Very High
Urological Neuroanatomy 2 99.48 Very High Very High Very High
Rhinitis 1 99.40 Very High Very High Very High
Neurodegenerative Disease 38 97.64 Very High Very High Very High
Retina Disease 6 96.88 Very High Very High Very High
Chondroblastoma 5 96.04 Very High Very High Very High
Malignant Neoplastic Disease 6 95.04 Very High Very High Very High
Fibrosis 2 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The histiocyte-like cells showed positive immunoreactivity for CD68, whereas they were negative for S-100 protein.
Positive_regulation (immunoreactivity) of CD68 in histiocyte
1) Confidence 0.39 Published 2007 Journal Mod. Pathol. Section Abstract Doc Link 17334342 Disease Relevance 1.31 Pain Relevance 0.16
Immunohistochemical study showed that the atypical cells were strongly reactive for vimentin and negative for CD68, while the giant cells were immunoreactive for CD68, but negative for vimentin.
Positive_regulation (negative) of CD68
2) Confidence 0.39 Published 2002 Journal Int. J. Clin. Oncol. Section Abstract Doc Link 12494256 Disease Relevance 0.68 Pain Relevance 0.08
Immunohistochemical study showed that the atypical cells were strongly reactive for vimentin and negative for CD68, while the giant cells were immunoreactive for CD68, but negative for vimentin.
Positive_regulation (immunoreactive) of CD68
3) Confidence 0.39 Published 2002 Journal Int. J. Clin. Oncol. Section Abstract Doc Link 12494256 Disease Relevance 0.68 Pain Relevance 0.08
These cells were negative for CD68 but positive for AE1/AE3.
Positive_regulation (negative) of CD68
4) Confidence 0.39 Published 2003 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 14567739 Disease Relevance 0.47 Pain Relevance 0.19
Relative to Control, progenitor proliferation and neurogenesis within the SGZ were significantly reduced following 10 Gy- (p < 0.001), and 15 Gy-WBI (p < 0.001), accompanied by a significant increase in CD68+ activated microglia (p < 0.001).
Positive_regulation (increase) of CD68 in microglia associated with neurodegenerative disease
5) Confidence 0.38 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2825515 Disease Relevance 0.64 Pain Relevance 0
The levels of activated caspase-3, CD68 and CD19 were significantly higher in the HUVEC-immunized rats compared to the PBS-treated controls (Figure 3J).
Positive_regulation (activated) of CD68
6) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC3009635 Disease Relevance 0.27 Pain Relevance 0.07
The detection of cells being positive for human CD68, a cellular marker for monocytes and macrophages, demonstrated that human cells take part in local processes of organisation of the lesion and the surrounding tissue.
Positive_regulation (positive) of CD68 in macrophages
7) Confidence 0.24 Published 2005 Journal GMS German Medical Science Section Body Doc Link PMC2703252 Disease Relevance 0.29 Pain Relevance 0
By immunohistochemical analysis, the characteristic histiocytes were positive for S100 protein and CD68 and negative for CD1a.
Positive_regulation (positive) of CD68 in histiocytes
8) Confidence 0.23 Published 2001 Journal Mod. Pathol. Section Abstract Doc Link 11266522 Disease Relevance 1.04 Pain Relevance 0.41
Immunohistologic studies on paraffin sections demonstrated that the majority of the tumor cells were strongly positive for CD45RB, CD68, and mast cell tryptase.
Positive_regulation (positive) of CD68 in mast cell associated with cancer
9) Confidence 0.18 Published 1999 Journal Mod. Pathol. Section Abstract Doc Link 10430280 Disease Relevance 0.98 Pain Relevance 0.08
Injection of eEPC and EPO was associated with increased CD68+ inflammatory cell recruitment and enhanced vessel formation.
Positive_regulation (increased) of CD68 associated with inflammation
10) Confidence 0.16 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2954875 Disease Relevance 0.68 Pain Relevance 0.22
By immunohistochemical analysis, the characteristic histiocytes were positive for S100 protein, CD68 and FXIIIa, but negative for CD1a.
Positive_regulation (positive) of CD68 in histiocytes
11) Confidence 0.15 Published 2005 Journal Zentralbl. Neurochir. Section Abstract Doc Link 16116557 Disease Relevance 0.99 Pain Relevance 0.16
Immunohistochemically, the histiocytic cells were positive for vimentin, CD68, and lysozyme and were negative for cytokeratin, S100 protein, estrogen and progesterone receptors, and CD10.
Positive_regulation (positive) of CD68
12) Confidence 0.12 Published 2004 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 15335251 Disease Relevance 0.65 Pain Relevance 0.08
Finally, striking plasmacytoid monocytes are also positive for CD68 but not for MPO [4].


Neg (not) Positive_regulation (for) of CD68 in plasmacytoid monocytes associated with urological neuroanatomy
13) Confidence 0.11 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1481509 Disease Relevance 1.72 Pain Relevance 0
OA patients showed more frequently positive staining for CD68 (P = 0.025) and apparently for PCNA.
Positive_regulation (staining) of CD68
14) Confidence 0.10 Published 2003 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 14505622 Disease Relevance 0.48 Pain Relevance 0.61
These cells exhibited medium-sized round nuclei with central nucleoli and eosinophilic cytoplasm, and were strongly positive for myeloperoxidase, CD68, lysozyme, CD45, CD117 (c-kit protein) and CD43.
Positive_regulation (positive) of CD68 associated with rhinitis
15) Confidence 0.09 Published 2006 Journal APMIS Section Abstract Doc Link 16948823 Disease Relevance 1.22 Pain Relevance 0.20
CCR2-/CD68-double positive cell number in postinfectious FD patients was significantly (P=0.009) increased compared with those in healthy volunteers.
Positive_regulation (increased) of CD68
16) Confidence 0.09 Published 2010 Journal Am. J. Gastroenterol. Section Body Doc Link 20461070 Disease Relevance 0 Pain Relevance 0
In addition, CD68-positive cell number in postinfectious FD patients was significantly increased compared with the numbers in subjects with epigastric pain syndrome or postprandial distress syndrome and in healthy volunteers.
Positive_regulation (increased) of CD68
17) Confidence 0.09 Published 2010 Journal Am. J. Gastroenterol. Section Body Doc Link 20461070 Disease Relevance 0 Pain Relevance 0
The detection of cells being positive for human CD68, a cellular marker for monocytes and macrophages, demonstrated that human cells take part in local processes of organisation of the lesion and the surrounding tissue.
Positive_regulation (positive) of CD68 in monocytes
18) Confidence 0.08 Published 2005 Journal GMS German Medical Science Section Body Doc Link PMC2703252 Disease Relevance 0.29 Pain Relevance 0
On immunohistochemical examination, the lesion stained positive for CD34 (Figure 7) and locally positive for SMA, and negative for CD68 and S-100 protein (Figure 8).
Positive_regulation (negative) of CD68
19) Confidence 0.07 Published 2011 Journal World J Surg Oncol Section Body Doc Link PMC3023681 Disease Relevance 0.49 Pain Relevance 0.08
Immunohistochemical characteristics of the disease include the positive reaction for vimentin, fibronectin and CD68[5], which were verified by the results from the present study.
Positive_regulation (reaction) of CD68 associated with disease
20) Confidence 0.06 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1564043 Disease Relevance 1.21 Pain Relevance 0.03

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