INT8332

Context Info Confidence 0.61 First Reported 1982 Last Reported 2011 Negated 1 Speculated 1 Reported most in Abstract Documents 30 Total Number 31 Disease Relevance 3.88 Pain Relevance 17.65

plasma membrane (OPRD1) cytoplasm (OPRD1) signal transducer activity (OPRD1)

Anatomy Link Frequency NG108-15 1 adrenal medulla 1 cingulate cortex 1 vesicles 1 amygdala 1 OPRD1 (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 78 100.00 Opioid 45 100.00 Delta opioid receptors 13 100.00 mu opioid receptor 6 100.00 midbrain 3 100.00 agonist 50 99.98 Enkephalin 35 99.88 Nucleus accumbens 6 99.68 antinociception 1 99.50 Versed 6 99.46

Disease Link Frequency Relevance Heat Stress 3 99.02 Depression 3 98.90 Hypoglycemia 3 98.32 Infarction 2 98.12 Rheumatoid Arthritis 6 97.96 Neuroblastoma 14 97.80 Glioma 3 97.76 Reprotox - General 2 1 97.52 Cv Unclassified Under Development 10 94.16 Drug Induced Neurotoxicity 1 91.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In NG108-15 cells, NDMC inhibited cyclic AMP formation and stimulated the phosphorylation of extracellular signal-regulated kinase 1/2 by activating the endogenously expressed delta-opioid receptor.

Positive_regulation (activating) of delta-opioid receptor in NG108-15 associated with opioid receptor

1) Confidence 0.61 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16841075 Disease Relevance 0 Pain Relevance 0.66

Midazolam was also weakly active at delta-receptor activation, whereas all three were inactive at mu receptors.

Positive_regulation (activation) of delta-receptor associated with versed

2) Confidence 0.59 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11473860 Disease Relevance 0 Pain Relevance 0.71

Activation of the delta-opioid receptor (DOR) system produces an interesting behavioral profile distinct from that of other opioids.

Positive_regulation (Activation) of delta-opioid receptor associated with opioid receptor and opioid

3) Confidence 0.56 Published 2006 Journal Mol. Interv. Section Abstract Doc Link 16809477 Disease Relevance 0.19 Pain Relevance 0.88

We demonstrate that the human delta opioid receptor is palmitoylated at two distinct cellular locations in human embryonic kidney 293 cells and undergoes dynamic regulation at one of these sites.

Positive_regulation (undergoes) of delta opioid receptor in embryonic kidney associated with opioid receptor

4) Confidence 0.50 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16595649 Disease Relevance 0 Pain Relevance 0.12

Therefore, activation of delta opioid receptor could modulate FCS-induced growth in some but not all neuroblastoma cell lines.

Positive_regulation (activation) of delta opioid receptor associated with neuroblastoma and opioid receptor

5) Confidence 0.50 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7815347 Disease Relevance 0.80 Pain Relevance 0.59

It is concluded that in man DT-induced activation of delta-opioid receptors exerts an inhibitory action on hypoglycemia-stimulated GH secretion.

Positive_regulation (activation) of delta-opioid associated with hypoglycemia and delta opioid receptors

6) Confidence 0.48 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1369601 Disease Relevance 0.27 Pain Relevance 0.33

In animal experiment and in cell culture, chronic morphine treatment has been followed by a reduction as well as an increase of the delta-opioid receptor (OR) number.

Positive_regulation (increase) of delta-opioid receptor associated with opioid receptor and morphine

7) Confidence 0.39 Published 2000 Journal Forensic Sci. Int. Section Abstract Doc Link 10978658 Disease Relevance 0.07 Pain Relevance 0.49

We have explored its intrinsic actions and found that it attenuated swim stress-induced antinociception, a model for endogenous delta-receptor activation.

Positive_regulation (activation) of delta-receptor associated with stress and antinociception

8) Confidence 0.38 Published 1989 Journal Neuropharmacology Section Abstract Doc Link 2559353 Disease Relevance 0.19 Pain Relevance 0.44

Agonist activation of the delta-opioid receptor leads to internalization via G betagamma recruitment of G protein coupled receptor kinase-2, which phosphorylates the receptor at several sites, including Ser363, allowing beta-arrestin binding and localization to clathrin coated pits.

Positive_regulation (activation) of delta-opioid receptor in pits associated with agonist and opioid receptor

9) Confidence 0.29 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19344370 Disease Relevance 0.07 Pain Relevance 0.29

Our results indicate that the inhibitory effect of opioids on T47D cell growth is mediated through kappa- and delta-opioid receptors.

Positive_regulation (mediated) of delta-opioid associated with delta opioid receptors and opioid

10) Confidence 0.16 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8838457 Disease Relevance 0.13 Pain Relevance 1.63

These studies also found evidence for secretin, prostacyclin, opioid and alpha2-adrenergic receptors In support of this we found significantly high levels of mRNA for Ptgir1, Ptger1, Ptger3, Ptger4, Oprd1, Oprl1 and Adra2b.

Positive_regulation (levels) of Oprd1 associated with opioid

11) Confidence 0.12 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0.08 Pain Relevance 0.14

Abnormal concentrations of caveolar cholesterol had no effect on met-enkephalin that stimulates a delta-opioid receptor that internalizes through clathrin.

Positive_regulation (stimulates) of delta-opioid receptor associated with opioid receptor and enkephalin

12) Confidence 0.07 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.51

These results suggest that delta-receptor activation contributes to the analgesia produced by metkephamid.

Positive_regulation (activation) of delta-receptor associated with analgesia

13) Confidence 0.07 Published 1982 Journal Life Sci. Section Abstract Doc Link 6292609 Disease Relevance 0 Pain Relevance 1.31

Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling.

Positive_regulation (activation) of delta opioid receptor in adrenal medulla associated with medulla, agonist and opioid receptor

14) Confidence 0.06 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16682504 Disease Relevance 0.08 Pain Relevance 0.34

We report that activation of delta-opioid-EGFP receptors triggers a rapid translocation of cytosolic GRK-DsRed toward the cell membrane, which in turn releases vesicles carrying both green fluorescent delta-receptors and red fluorescent GRKs.

Positive_regulation (activation) of delta-opioid in vesicles associated with opioid

15) Confidence 0.05 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11805194 Disease Relevance 0.20 Pain Relevance 0.32

One hypothetical model proposes that reward results from activation of mu-opioid receptors in the VTA and/or delta-receptor in the NAC; both these nuclei are targets of endogenous beta-endorphin.

Positive_regulation (activation) of delta-receptor in VTA associated with nucleus accumbens, mu opioid receptor and midbrain

16) Confidence 0.04 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9040115 Disease Relevance 0.15 Pain Relevance 1.39

The effects of opioid delta-receptor activation on conditioning in a one-way active avoidance paradigm were investigated in mice.

Spec (investigated) Positive_regulation (activation) of delta-receptor associated with opioid

17) Confidence 0.02 Published 1988 Journal Behav. Neurosci. Section Abstract Doc Link 2848536 Disease Relevance 0 Pain Relevance 0.57

CONCLUSIONS: The proseizure effect of morphine is mediated through selective stimulation of mu and kappa opiate receptors but not the activation of the delta receptor system.

Neg (not) Positive_regulation (activation) of delta receptor

18) Confidence 0.01 Published 2007 Journal Anesth. Analg. Section Body Doc Link 18042875 Disease Relevance 0 Pain Relevance 0

We have addressed the possibility that removal of maternal milk is the stimulus for the weaning-induced delta-receptor activation by studying the effect of lactating and nonlactating surrogate mothers and two milk substitutes (casein-rich and casein-free) on opioid receptor control of swim SIA.

Positive_regulation (activation) of delta-receptor associated with opioid receptor

19) Confidence 0.01 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11181901 Disease Relevance 0.09 Pain Relevance 0.27

Independent groups received an injection of either the vehicle or the delta-receptor agonist [D-Ala2-,N-Me-Phe4,Gly-ol] enkephalin (DPDPE; 24 microg/kg).

Positive_regulation (injection) of delta-receptor associated with agonist and enkephalin

20) Confidence 0.01 Published 2005 Journal Behav. Neurosci. Section Abstract Doc Link 15839790 Disease Relevance 0 Pain Relevance 0.31

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