INT83325

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Context Info
Confidence 0.48
First Reported 1999
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.59
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 6
NK cell 4
B-cell 2
spleen 2
mesencephalon 2
Il2ra (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 18 100.00 Very High Very High Very High
Central grey 15 100.00 Very High Very High Very High
ischemia 18 98.92 Very High Very High Very High
abdominal pain 2 92.20 High High
Central nervous system 16 87.44 High High
Multiple sclerosis 11 82.36 Quite High
cytokine 64 71.20 Quite High
tolerance 5 68.40 Quite High
Inflammation 73 66.56 Quite High
nMDA receptor 1 60.08 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 22 100.00 Very High Very High Very High
Transient Ischemic Attack 16 98.92 Very High Very High Very High
Ocular Injury 29 98.86 Very High Very High Very High
Disease 16 97.60 Very High Very High Very High
Multiple Sclerosis 52 95.60 Very High Very High Very High
Splenomegaly 1 92.76 High High
Abdominal Pain 2 92.20 High High
Autoimmune Disease 12 88.20 High High
Lymphoproliferative Disease 2 88.12 High High
Epstein-barr Virus 3 84.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result suggests that a penetrating ocular injury at an early stage after an AC injection of OVA does not alter the expression of CD4+CD25+Foxp3+T cells and thereby does not result in the induction of ACAID.
Neg (not) Regulation (alter) of Gene_expression (expression) of CD25 in T cells associated with ocular injury
1) Confidence 0.48 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.60 Pain Relevance 0.03
In parallel, to test whether VT680 activates cells in vivo, we measured levels of CD25 and CD44 expression on Thy1.2 (VT680+) and Thy1.1 (unstained) cells (Fig. 1J).
Regulation (levels) of Gene_expression (expression) of CD25
2) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2034600 Disease Relevance 0.17 Pain Relevance 0.04
In our study, we have demonstrated that repetitive PTx treatment elevated frequency as well as mean FoxP3 expression of CD4+CD25+FoxP3+ T cells.
Regulation (repetitive) of Gene_expression (expression) of CD25 in T cells
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.66 Pain Relevance 0.18
The strong down-regulation of CD25 expression of CD3-activated T cells by Gal-4 proves the biological consequence of the Gal-4 binding to the CD3 complex.
Regulation (regulation) of Gene_expression (expression) of CD25 in T cells
4) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.12 Pain Relevance 0.06
The purpose of the present study was to determine the morphologic changes of the rat spleen after transient cerebral ischemia by agmatine treatment and to verify splenic immune responses after transient cerebral ischemia with or without agmatine treatment by confirming the changes in the expression of CD11b+ macrophages, CD4+CD25+ regulatory T (T reg) cells, and CD8+ cytotoxic T lymphocytes (CTLs).


Regulation (changes) of Gene_expression (expression) of CD25 in spleen associated with transient ischemic attack and ischemia
5) Confidence 0.08 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998779 Disease Relevance 0.26 Pain Relevance 0.16
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Regulation (effects) of in NK cell Gene_expression (expression) of CD25 in mesencephalon associated with central grey and morphine
6) Confidence 0.07 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.45 Pain Relevance 0.60
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Regulation (effects) of in NK cell Gene_expression (expression) of CD25 in mesencephalon associated with central grey and morphine
7) Confidence 0.07 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.45 Pain Relevance 0.60
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Spec (investigated) Regulation (effects) of Gene_expression (production) of CD25 in NK cell associated with central grey and morphine
8) Confidence 0.07 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.45 Pain Relevance 0.60
Immunophenotyping revealed a clonal B-cell population coexpressing CD5, CD19, and CD20 with weak CD23 and CD25 and very weak, restricted, surface lambda.
Regulation (population) of Gene_expression (coexpressing) of CD25 in B-cell
9) Confidence 0.04 Published 2003 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 12810261 Disease Relevance 0.43 Pain Relevance 0.09

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