INT83328

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Context Info
Confidence 0.43
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.55
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
dendritic cell 2
CD3 2
NK cell 1
mesencephalon 1
Cd4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 52 100.00 Very High Very High Very High
Morphine 12 100.00 Very High Very High Very High
Central grey 10 100.00 Very High Very High Very High
dorsal root ganglion 42 73.92 Quite High
Inflammation 8 50.00 Quite Low
Peripheral nerve injury 3 32.40 Quite Low
Neuropathic pain 12 8.12 Low Low
antagonist 18 5.00 Very Low Very Low Very Low
corticosteroid 15 5.00 Very Low Very Low Very Low
withdrawal 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 12 100.00 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 146 99.64 Very High Very High Very High
Fungal Infection 14 95.56 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 100 91.56 High High
Injury 33 82.48 Quite High
Ganglion Cysts 42 73.92 Quite High
Hypersensitivity 5 50.00 Quite Low
INFLAMMATION 8 32.96 Quite Low
Nervous System Injury 8 32.40 Quite Low
Neuropathic Pain 16 24.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cellularity and dendritic cell content in DLNC population, as well as the expression of TCR-alpha, CD4, CD8 and CD25, were not changed between irradiated and nonirradiated animals.
Neg (not) Regulation (changed) of Gene_expression (expression) of CD4 in dendritic cell
1) Confidence 0.43 Published 2003 Journal Photodermatol Photoimmunol Photomed Section Body Doc Link 12925192 Disease Relevance 0 Pain Relevance 0
In the multivariate analyses, the estimated annual change in CD4 count from 1997 to 2007 was higher among ?
Regulation (change) of Gene_expression (count) of CD4
2) Confidence 0.42 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC3022663 Disease Relevance 0.41 Pain Relevance 0
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Regulation (effects) of in NK cell Gene_expression (expression) of CD4 in mesencephalon associated with central grey and morphine
3) Confidence 0.37 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.44 Pain Relevance 0.57
Changes in chemokine expression following perineural gp120/hCD4 alone and in combination with ddC treatment
Regulation (Changes) of Gene_expression (expression) of hCD4 associated with chemokine
4) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.27 Pain Relevance 0.14
Furthermore, morphine did not alter the expression of CD3, CD4, CD8, and NKR-P1 surface markers, but significantly (p < 0.001) downregulated the expression of CD25 and CD71 receptors following in vitro activation.
Neg (not) Regulation (alter) of Gene_expression (expression) of CD4 in CD3 associated with morphine
5) Confidence 0.22 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.39 Pain Relevance 0.71
Larger change in CD4+ percentage (HR?
Regulation (change) of Gene_expression (percentage) of CD4
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2895658 Disease Relevance 1.04 Pain Relevance 0

General Comments

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