INT83332

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Context Info
Confidence 0.22
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.03
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TFRC) peptidase activity (TFRC) mitochondrion (TFRC)
aging (TFRC) extracellular region (TFRC) cytoplasmic membrane-bounded vesicle (TFRC)
Anatomy Link Frequency
NK cell 3
mesencephalon 3
TFRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 18 100.00 Very High Very High Very High
Central grey 15 100.00 Very High Very High Very High
Inflammation 53 93.44 High High
cytokine 21 5.00 Very Low Very Low Very Low
fibrosis 20 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 18 100.00 Very High Very High Very High
Stress 127 98.36 Very High Very High Very High
Pulmonary Alveolar Proteinosis 69 94.84 High High
INFLAMMATION 62 93.44 High High
Liver Disease 43 83.84 Quite High
Injury 49 74.08 Quite High
Iron Overload 6 64.60 Quite High
Pulmonary Disease 5 58.56 Quite High
Disease 23 53.92 Quite High
Pneumoconiosis 1 51.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IRP inactivation should, by down-regulating TfR expression and up-regulating Ft, decrease the intracellular labile iron pool, thus preventing amplification of iron-mediated oxidative damage.
Regulation (regulating) of Gene_expression (expression) of TfR
1) Confidence 0.22 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.64 Pain Relevance 0.03
With exposure to iron, many cell types rapidly down regulate TfR expression to limit iron uptake.
Regulation (regulate) of Gene_expression (expression) of TfR
2) Confidence 0.13 Published 2008 Journal Respir Res Section Body Doc Link PMC2265287 Disease Relevance 1.03 Pain Relevance 0.13
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Regulation (effects) of in NK cell Gene_expression (expression) of CD71 in mesencephalon associated with central grey and morphine
3) Confidence 0.04 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.45 Pain Relevance 0.61
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Regulation (effects) of in NK cell Gene_expression (expression) of CD71 in mesencephalon associated with central grey and morphine
4) Confidence 0.03 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.45 Pain Relevance 0.61
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Regulation (effects) of in NK cell Gene_expression (expression) of CD71 in mesencephalon associated with central grey and morphine
5) Confidence 0.03 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.45 Pain Relevance 0.61

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