INT83349

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Context Info
Confidence 0.39
First Reported 1999
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.48
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSR) mitochondrion (GSR) small molecule metabolic process (GSR)
oxidoreductase activity (GSR) cytoplasm (GSR)
GSR (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 13 98.64 Very High Very High Very High
cINOD 2 95.12 Very High Very High Very High
Inflammation 30 89.84 High High
rheumatoid arthritis 1 68.20 Quite High
dexamethasone 4 41.92 Quite Low
agonist 4 18.60 Low Low
cva 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
opiate 3 5.00 Very Low Very Low Very Low
medulla 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Occupational Lung Diseases 9 99.68 Very High Very High Very High
Inflammatory Bowel Disease 2 97.44 Very High Very High Very High
Sepsis 33 96.20 Very High Very High Very High
Asthma 16 95.52 Very High Very High Very High
INFLAMMATION 36 94.88 High High
Adult Respiratory Distress Syndrome 1 69.68 Quite High
Rheumatoid Arthritis 1 68.20 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 67.32 Quite High
Disease 5 65.68 Quite High
Glaucoma 1 47.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After binding to the glucocorticoid receptor (GR), they repress the synthesis of proinflammatory cytokines via inhibition of the transcription factors AP-1 and NF-kappa B.
Negative_regulation (repress) of GR Binding (binding) of associated with cytokine
1) Confidence 0.39 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10435109 Disease Relevance 0.57 Pain Relevance 0.24
Most of the studies showing GR downregulation also found decreased cytosolic GR binding, which may result from compartmentalization of the GR during the acute response to cytokines.
Negative_regulation (decreased) of GR Binding (binding) of associated with cytokine
2) Confidence 0.28 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.81 Pain Relevance 0.25
In opposition to these different reports, others have shown the amount of GR?
Negative_regulation (shown) of GR Binding (amount) of
3) Confidence 0.16 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.10 Pain Relevance 0

General Comments

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