INT83350

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Context Info
Confidence 0.52
First Reported 1999
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.68
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (JUND)
JUND (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 99.90 Very High Very High Very High
dexamethasone 2 97.60 Very High Very High Very High
qutenza 3 93.44 High High
Inflammation 6 91.08 High High
cINOD 3 90.92 High High
Bioavailability 1 79.12 Quite High
Disease Link Frequency Relevance Heat
Repression 2 100.00 Very High Very High Very High
Apoptosis 2 97.40 Very High Very High Very High
Occupational Lung Diseases 2 95.48 Very High Very High Very High
Asthma 8 91.32 High High
INFLAMMATION 8 91.08 High High
Cancer 4 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some of these agents (EGCG, genistein, and curcumin) appear to directly target specific RTKs, and all of these compounds cause inhibition of the activity of the transcription factors AP-1 and NF-kappaB, thus inhibiting cell proliferation and enhancing apoptosis.
Negative_regulation (inhibition) of AP-1 associated with apoptosis
1) Confidence 0.52 Published 2005 Journal Mutat. Res. Section Abstract Doc Link 15992833 Disease Relevance 0.39 Pain Relevance 0.13
After binding to the glucocorticoid receptor (GR), they repress the synthesis of proinflammatory cytokines via inhibition of the transcription factors AP-1 and NF-kappa B.
Negative_regulation (inhibition) of AP-1 associated with cytokine
2) Confidence 0.26 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10435109 Disease Relevance 0.58 Pain Relevance 0.24
The GC-independent repression of AP-1 and NF-kappa B activities was further demonstrated by overexpressing a ligand-binding deficient GR mutant.
Negative_regulation (repression) of AP-1 associated with repression
3) Confidence 0.19 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10435109 Disease Relevance 0.70 Pain Relevance 0.32
Theoretical prediction of the relationship between phenol function and COX-2/AP-1 inhibition for ferulic acid-related compounds.
Negative_regulation (inhibition) of AP-1
4) Confidence 0.01 Published 2005 Journal In Vivo Section Title Doc Link 16277019 Disease Relevance 0 Pain Relevance 0.05

General Comments

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