INT83351

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Context Info
Confidence 0.64
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 12.03
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSR) mitochondrion (GSR) small molecule metabolic process (GSR)
oxidoreductase activity (GSR) cytoplasm (GSR)
Anatomy Link Frequency
spinal cord 2
lung epithelium 2
GSR (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 163 99.72 Very High Very High Very High
cytokine 87 99.48 Very High Very High Very High
Inflammation 294 99.30 Very High Very High Very High
Spinal cord 30 96.38 Very High Very High Very High
dexamethasone 8 96.08 Very High Very High Very High
antagonist 5 92.84 High High
Multiple sclerosis 32 85.92 High High
cINOD 10 84.24 Quite High
depression 3 34.96 Quite Low
corticosteroid 7 19.44 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 11 99.82 Very High Very High Very High
Rheumatoid Arthritis 163 99.72 Very High Very High Very High
INFLAMMATION 331 99.30 Very High Very High Very High
Asthma 146 99.14 Very High Very High Very High
Repression 4 98.74 Very High Very High Very High
Disease 112 98.08 Very High Very High Very High
Multiple Sclerosis 132 96.78 Very High Very High Very High
Stroke 29 94.32 High High
Occupational Lung Diseases 75 92.72 High High
Stress 155 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since qualitative and quantitative defects of the GR have been reported in corticoresistant patients, the transfer of the GR gene in the lung epithelium, the primary site of inflammation in asthma, may restore sensitivity to GC in these patients.
Positive_regulation (transfer) of Gene_expression (transfer) of GR gene in lung epithelium associated with asthma and inflammation
1) Confidence 0.64 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10435109 Disease Relevance 0.66 Pain Relevance 0.28
The GC-independent repression of AP-1 and NF-kappa B activities was further demonstrated by overexpressing a ligand-binding deficient GR mutant.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of GR associated with repression
2) Confidence 0.64 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10435109 Disease Relevance 0.69 Pain Relevance 0.31
Using AP-1 and NF-kappa B-dependent reporter gene assays and an immunoassay for the pro-inflammatory cytokine RANTES, we show that the over-expressed GR significantly repressed AP-1 and NF-kappa B activities in the absence of hormone and that the GC dexamethasone produced an additive inhibitory effect.
Positive_regulation (over-expressed) of Gene_expression (over-expressed) of GR associated with inflammation, dexamethasone and cytokine
3) Confidence 0.46 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10435109 Disease Relevance 0.72 Pain Relevance 0.33
The hypothesis of GR compartmentalization may be supported by the fact that LPS and IL-1?
Positive_regulation (supported) of Gene_expression (compartmentalization) of GR
4) Confidence 0.28 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.75 Pain Relevance 0.20
The ability of overexpressed GR?
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of GR
5) Confidence 0.26 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.66 Pain Relevance 0.04
gene and the generation of transgenic animals overexpressing GR?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of GR associated with targeted disruption
6) Confidence 0.26 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.65 Pain Relevance 0.13
This result suggests that overexpression of GR?
Positive_regulation (overexpression) of Gene_expression (overexpression) of GR
7) Confidence 0.19 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.35 Pain Relevance 0.09
over GR?
Positive_regulation (over) of Gene_expression (over) of GR
8) Confidence 0.19 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.73 Pain Relevance 0.05
It should be noted that resistance to GCs may result from the reduced expression of GR?
Spec (may) Positive_regulation (result) of Gene_expression (expression) of GR
9) Confidence 0.19 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.50 Pain Relevance 0.04
Increased GR expression in the lesion hemisphere could therefore promote plasticity and maintain integrity of existing pathways thus facilitating compensation after stroke.
Positive_regulation (Increased) of Gene_expression (expression) of GR associated with stroke
10) Confidence 0.19 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2954925 Disease Relevance 0.84 Pain Relevance 0.04
in cells from asthmatic patients, the establishment of cell lines containing an inducible GR?
Positive_regulation (inducible) of Gene_expression (containing) of GR associated with asthma
11) Confidence 0.17 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.64 Pain Relevance 0.13
Enhanced expression of GR?
Positive_regulation (Enhanced) of Gene_expression (expression) of GR
12) Confidence 0.07 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 1.38 Pain Relevance 0.57
Moreover, glucocorticoid receptor expression in spinal cord is lower in the EAE+S group at 12 days than in the control group, indicating a possible dysregulation of HPA feedback regulation (high levels of corticosterone not correlated with increased expression of GR) which indicates that hypofunction of the axis increases vulnerability and severity of EAE.
Positive_regulation (increased) of Gene_expression (expression) of GR in spinal cord associated with multiple sclerosis and spinal cord
13) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.38 Pain Relevance 0.29
One of the proposed mechanisms which may be responsible for this phenomenon is upregulation in the expression of GR-?
Positive_regulation (upregulation) of Gene_expression (expression) of GR
14) Confidence 0.05 Published 2007 Journal Annals of Thoracic Medicine Section Body Doc Link PMC2732069 Disease Relevance 0.80 Pain Relevance 0
Recently, Neeck and colleagues, evaluating the expression of GR by immunoblot analysis, showed a higher expression of GR in untreated patients with RA in comparison with controls but a decreased GR expression in glucocorticoid-treated patients with RA in comparison with controls [202].
Positive_regulation (higher) of Gene_expression (expression) of GR associated with rheumatoid arthritis
15) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 1.11 Pain Relevance 0.43
Moreover, overexpression of GR by co-transfection of a GR expression vector and a GRE-luciferase vector enhanced the transactivation activity of the GRE promoter in the presence of the two different ginsenosides (38).
Positive_regulation (overexpression) of Gene_expression (overexpression) of GR
16) Confidence 0.03 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193541 Disease Relevance 0.17 Pain Relevance 0.05

General Comments

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