INT83358

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Context Info
Confidence 0.21
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 8.14
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Elane) cytoplasm (Elane)
Anatomy Link Frequency
lung 2
neutrophil 2
macrophages 1
plasma 1
leukocyte 1
Elane (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 89 99.32 Very High Very High Very High
metalloproteinase 100 96.40 Very High Very High Very High
amygdala 31 95.16 Very High Very High Very High
cytokine 60 90.80 High High
Inflammation 267 90.40 High High
rheumatoid arthritis 31 87.12 High High
fibrosis 19 79.40 Quite High
methotrexate 1 71.76 Quite High
transdermal 1 69.60 Quite High
anesthesia 1 69.12 Quite High
Disease Link Frequency Relevance Heat
Cancer 272 99.68 Very High Very High Very High
Lung Injury 15 99.60 Very High Very High Very High
Arthritis 93 99.32 Very High Very High Very High
Pulmonary Disease 320 99.12 Very High Very High Very High
Disease 72 98.84 Very High Very High Very High
Pancreatitis 2 98.84 Very High Very High Very High
Cv General 4 Under Development 6 98.60 Very High Very High Very High
Congenital Anomalies 1 98.16 Very High Very High Very High
Ketoacidosis 5 95.64 Very High Very High Very High
Nicotine Addiction 57 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A positive regulatory role for CD69 in neutrophil function during arthritis induction in CAIA was reported [71], but a recent study ruled out such a significant stimulatory role for it [72].
Positive_regulation (role) of neutrophil in neutrophil associated with arthritis
1) Confidence 0.21 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.38 Pain Relevance 0.78
Therefore, the exponential increase of Ne over time in tumor tissues was apparently not related to an increased evolutionary rate of the virus in the infiltrating macrophages.
Positive_regulation (increase) of Ne in macrophages associated with cancer
2) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780293 Disease Relevance 0.58 Pain Relevance 0
One hypothesis that could explain the increase in viral Ne within tumor clades is a higher viral evolutionary rate leading to increased diversity and resulting, in turn, into higher estimates of effective population size over time.
Positive_regulation (increase) of Ne associated with cancer
3) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780293 Disease Relevance 0.80 Pain Relevance 0
1-PI to increase NE-mediated lung injury, and NE cleaving and inactivating TIMP-1 to amplify MMP-12-mediated lung destruction (Shapiro et al 2003).
Positive_regulation (increase) of NE in lung associated with lung injury
4) Confidence 0.09 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.97 Pain Relevance 0.14
Since then, additional studies have confirmed increased levels of NE in lung samples from COPD patients and demonstrated elevated levels of CG, PR3, uPA, and MMPs -1, -2, -8, -9, and -14 in various lung samples from smokers and COPD patients when compared with healthy subjects (Damiano et al 1986; Reilly and Chapman Jr 1988; Abboud et al 1998; Betsuyaku et al 1996; Finlay et al 1997; Betsuyaku et al 1999; Hill et al 1999; Betsuyaku et al 2000b; Cataldo et al 2000; Imai et al 2001; Beeh et al 2003; Kang et al 2003).
Positive_regulation (increased) of NE in lung associated with nicotine addiction, pulmonary disease and metalloproteinase
5) Confidence 0.09 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 1.19 Pain Relevance 0.18
One of the major actions of neutrophil elastase is its ability to degrade matrix proteins and appears to be a key enzyme in the development of hereditary due to ?
Positive_regulation (actions) of neutrophil elastase in neutrophil
6) Confidence 0.08 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.99 Pain Relevance 0.24
In order to determine the main factors that lead to this increase, serum total amylase (TA), pancreatic amylase (PA), lipase (L) and leukocyte elastase (LE), an early predictor of acute pancreatitis, were measured in four groups of patients on admission.
Spec (determine) Positive_regulation (lead) of leukocyte elastase in leukocyte associated with pancreatitis
7) Confidence 0.02 Published 1999 Journal Acta Diabetol Section Abstract Doc Link 10436251 Disease Relevance 0.75 Pain Relevance 0
Additionally, there was a significant increase in plasma IL-1 and IL-6 and in BALF IL-6, IL-8, IL-10, NE, and protein concentration in the SMA + FC group.
Positive_regulation (increase) of NE in plasma associated with cv general 4 under development
8) Confidence 0.01 Published 2005 Journal Shock Section Abstract Doc Link 16205320 Disease Relevance 1.50 Pain Relevance 0.20
NE levels were increased to approximately 75% above a basal concentration.
Positive_regulation (increased) of NE
9) Confidence 0.01 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0 Pain Relevance 0.29

General Comments

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