INT83370

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Context Info
Confidence 0.30
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HRAS, TP53) cytoplasm (HRAS, TP53) cytosol (HRAS, TP53)
cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
Anatomy Link Frequency
bile 1
HRAS (Homo sapiens)
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 2 100.00 Very High Very High Very High
palliative 1 64.76 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 2 100.00 Very High Very High Very High
Cancer 4 79.12 Quite High
Aggression 1 78.56 Quite High
Disease 3 70.24 Quite High
Recurrence 1 69.32 Quite High
Uterine Cancer 1 39.80 Quite Low
Ovarian Cancer 1 37.72 Quite Low
Adenocarcinoma 1 31.44 Quite Low
Gastrointestinal Disease 1 25.00 Low Low
Malignant Neoplastic Disease 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From these, K-ras mutations detected in blood, stool and bile juice of patients at risk for pancreatic cancer seem to be more promising than p53 alterations as a more later step in carcinogenesis, although they are neither yet well established nor standardised by reliable assays.
K-ras Binding (alterations) of p53 in bile associated with bile and pancreatic cancer
1) Confidence 0.30 Published 1999 Journal Ann. Oncol. Section Abstract Doc Link 10436809 Disease Relevance 0.59 Pain Relevance 0.11

General Comments

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