INT83374

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 83
Total Number 83
Disease Relevance 44.18
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF7) extracellular space (FGF7) extracellular region (FGF7)
Golgi apparatus (FGF7)
Anatomy Link Frequency
fibroblasts 18
keratinocytes 17
epithelial cells 9
bars 3
mammary gland 1
FGF7 (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 1 100.00 Very High Very High Very High
Inflammation 208 99.08 Very High Very High Very High
adenocard 71 99.00 Very High Very High Very High
cytokine 68 98.56 Very High Very High Very High
Neurotransmitter 7 96.20 Very High Very High Very High
Pain 167 93.32 High High
Bile 2 90.48 High High
Osteoarthritis 13 85.84 High High
metalloproteinase 18 78.56 Quite High
palliative 33 71.76 Quite High
Disease Link Frequency Relevance Heat
Cancer 5333 99.86 Very High Very High Very High
Alopecia 1 99.82 Very High Very High Very High
Pancreatic Cancer 68 99.66 Very High Very High Very High
Carcinoma 5 99.66 Very High Very High Very High
Breast Cancer 68 99.60 Very High Very High Very High
Wound Healing 20 99.52 Very High Very High Very High
Malignant Neoplastic Disease 229 99.44 Very High Very High Very High
Adenocarcinoma 66 99.24 Very High Very High Very High
INFLAMMATION 211 99.08 Very High Very High Very High
Benign Prostatic Hypertrophy 64 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of this study showed that palifermin did not promote the growth of two carcinoma cell lines that express functional KGF receptors and did not protect these tumor cells from the antitumor effects of several chemotherapeutic and biological agents.
Gene_expression (express) of KGF associated with cancer and carcinoma
1) Confidence 0.78 Published 2008 Journal Mol. Cancer Res. Section Abstract Doc Link 18708365 Disease Relevance 0.60 Pain Relevance 0
Nude CD1 mice were injected with 1 x 10(7) of either FaDu or HT29 cells, which express both KGF and epithelial growth factor receptors.
Gene_expression (express) of KGF in FaDu
2) Confidence 0.78 Published 2008 Journal Mol. Cancer Res. Section Abstract Doc Link 18708365 Disease Relevance 0.75 Pain Relevance 0.07
Predominantly, KGF is produced by mesenchymal cells, and target cells are of epithelial origin.
Gene_expression (produced) of KGF in mesenchymal cells
3) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.41 Pain Relevance 0.03
However, where tested, KGF expression was confirmed on the RNA level, suggesting true KGF synthesis in epithelial cells.
Gene_expression (expression) of KGF in epithelial cells
4) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.74 Pain Relevance 0.06
Unexpectedly, we also found KGF mRNA and protein expression in primary keratinocytes, RNA expression being up-regulated by irradiation.
Gene_expression (expression) of KGF mRNA in keratinocytes
5) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.45 Pain Relevance 0
Bansal et al. (1997) described the expression of KGF mRNA in human breast cancer cell lines and purified populations of epithelial cells, Shaoul et al. (2006) found markedly increased KGF protein levels in the mucosal epithelium of patients with gastric inflammation, as well as in gastric adenocarcinoma.
Gene_expression (expression) of KGF mRNA in epithelial cells associated with adenocarcinoma, inflammation and breast cancer
6) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.85 Pain Relevance 0.09
In conclusion, KGF expression was found in primary and immortalized keratinocytes and in tumour cell cultures established from head and neck cancer, while relevant KGFreceptor expression was only found in keratinocytes.
Gene_expression (expression) of KGF in neck associated with cancer and head & neck cancer
7) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.76 Pain Relevance 0.03
In contrast, KGF receptor, at the expected molecular weight, was only detected in keratinocytes.
Gene_expression (detected) of KGF receptor in keratinocytes
8) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.71 Pain Relevance 0
KGF mRNA expression in fibroblasts was increased after 24 h.
Gene_expression (expression) of KGF mRNA in fibroblasts
9) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.58 Pain Relevance 0
The expression of KGF and KGF receptor in tumour cell lines, primary fibroblasts, primary keratinocytes, and HaCat cells was tested by Western Blot analysis.
Gene_expression (expression) of KGF receptor in fibroblasts associated with cancer
10) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.18 Pain Relevance 0
For confirmation, immortalized keratinocytes (HaCat cells) were tested and showed KGF mRNA expression and secretion as well.
Gene_expression (expression) of KGF mRNA in keratinocytes
11) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.36 Pain Relevance 0
The expression of the KGF receptor in primary keratinocytes was expected and could be shown by Western blot and real-time PCR.
Gene_expression (expression) of KGF receptor in keratinocytes
12) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.67 Pain Relevance 0.03
Moreover, the endogenous KGF expression by the tumour cells may render them independent of exogenous KGF signalling, thus suggesting replacement of the normal paracrine with an autocrine mechanism in case of malignant growth.
Gene_expression (expression) of KGF associated with malignant neoplastic disease and cancer
13) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 1.08 Pain Relevance 0
Others (Drugan et al. 1997; Ning et al. 1998) found no correlation between KGF cell surface receptor expression and KGF-induced proliferation.
Gene_expression (expression) of KGF
14) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.59 Pain Relevance 0
Others (Drugan et al. 1997; Ning et al. 1998) found no correlation between KGF cell surface receptor expression and KGF-induced proliferation.
Gene_expression (expression) of KGF
15) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.60 Pain Relevance 0
Measurements were performed in duplicate and experiments were repeated two times. b Radiation-induced changes in KGF receptor expression in keratinocytes (KTC) and HaCat cells.
Gene_expression (expression) of KGF receptor in keratinocytes
16) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.29 Pain Relevance 0
Keratinocyte growth factor [KGF; also termed fibroblast growth factor 7 (FGF7)] is predominantly produced by cells of mesenchymal origin and acts exclusively through a specific KGF receptor [fibroblast growth factor receptor (FGFR2b)], which is expressed primarily by epithelial cells.
Gene_expression (produced) of FGF7 in epithelial cells
17) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.59 Pain Relevance 0.15
However, where tested, KGF expression was confirmed on the RNA level, suggesting true KGF synthesis in epithelial cells.
Gene_expression (synthesis) of KGF in epithelial cells
18) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.73 Pain Relevance 0.06
Figure 2a summarizes the results; the mRNA expression is normalized to the unirradiated controls.Fig. 2a Radiation-induced changes in KGF expression in normal (KTC = primary keratinocytes, HaCat = immortalized keratinocytes, DF-19 = primary fibroblasts) and tumour cells (BW-225, ZMK-1, GR-145, OH-65).
Gene_expression (expression) of KGF in keratinocytes associated with cancer
19) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.45 Pain Relevance 0
The expression of KGF and KGF receptor in tumour cell lines, primary fibroblasts, primary keratinocytes, and HaCat cells was tested by Western Blot analysis.
Gene_expression (expression) of KGF in fibroblasts associated with cancer
20) Confidence 0.78 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.18 Pain Relevance 0

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