INT8339

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Context Info
Confidence 0.57
First Reported 1988
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 4.90
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GC) extracellular space (GC) small molecule metabolic process (GC)
extracellular region (GC)
Anatomy Link Frequency
blood 2
parasympathetic 1
GC (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 6 99.68 Very High Very High Very High
beta blocker 1 85.64 High High
anesthesia 4 84.08 Quite High
intrathecal 1 82.56 Quite High
headache 6 75.04 Quite High
ischemia 5 71.48 Quite High
Pain 2 69.52 Quite High
depression 2 67.48 Quite High
Catecholamine 2 64.68 Quite High
nud 1 58.32 Quite High
Disease Link Frequency Relevance Heat
Hypertension 22 99.48 Very High Very High Very High
Fatigue 6 95.92 Very High Very High Very High
Hypotension 2 93.36 High High
Renal Failure 8 87.72 High High
Stroke 5 85.20 High High
Aging 3 81.44 Quite High
Rabies Virus Infection 12 78.52 Quite High
Pressure And Volume Under Development 5 78.08 Quite High
Reprotox - General 2 1 75.64 Quite High
Decubitus Ulcers 1 75.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decreases in MBP and DBP were persistent after 60 minutes.
Negative_regulation (decreases) of DBP
1) Confidence 0.57 Published 1989 Journal Reg Anesth Section Abstract Doc Link 2487666 Disease Relevance 0.47 Pain Relevance 0.34
Over the 8 week period, felodipine reduced the seated dBP from 100 to 83 mm Hg and propranolol from 101 to 86 mm Hg.
Negative_regulation (reduced) of dBP
2) Confidence 0.57 Published 1988 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 3289947 Disease Relevance 0.51 Pain Relevance 0.09
Clonidine administration decreased SBP, DBP and NE levels in PreMW, in PeriMW and in PeriMWE without any difference between the groups (F = 1.2, p = NS; F = 0.5, p = NS and F = 1.3, P = NS respectively).
Negative_regulation (decreased) of DBP associated with clonidine
3) Confidence 0.57 Published 1997 Journal J. Endocrinol. Invest. Section Abstract Doc Link 9438918 Disease Relevance 0.06 Pain Relevance 0.52
The results indicated that TP compression (1) decreased HR, SBP and DBP, (2) increased parasympathetic activity, (3) increased the gain from ILV to HR, and (4) improved the fatigue scores.
Negative_regulation (decreased) of DBP in parasympathetic associated with fatigue
4) Confidence 0.42 Published 2009 Journal J Physiol Sci Section Abstract Doc Link 19340540 Disease Relevance 0.27 Pain Relevance 0
Maximum increase and decrease in DBP and MAP follow the same pattern and increase in blood pressures remained below 15% of the baseline value.
Negative_regulation (decrease) of DBP in blood
5) Confidence 0.42 Published 2008 Journal J Pak Med Assoc Section Body Doc Link 18297973 Disease Relevance 0 Pain Relevance 0
Patients received barnidipine at a dose titrated to achieve a sitting DBP > or = 90 mmHg or a decrease in sitting BDP > or = 10 mmHg.
Negative_regulation (decrease) of DBP
6) Confidence 0.42 Published 2000 Journal Int J Clin Pract Suppl Section Abstract Doc Link 11221291 Disease Relevance 0.25 Pain Relevance 0.05
Moreover, data from a randomised, double-blind, placebo-controlled, dose-finding study in 1038 patients with mild to moderate hypertension showed that the greatest reductions in SBP/DBP were achieved by candesartan cilexetil 16 mg/hydrochlorothiazide 12.5 mg.
Negative_regulation (reductions) of DBP associated with hypertension
7) Confidence 0.42 Published 2002 Journal Drugs Section Abstract Doc Link 11929332 Disease Relevance 0.40 Pain Relevance 0.03
P and N were equally effective in reducing SBP (p = 0.843, NS) and DBP (p = 0.612, NS).
Negative_regulation (reducing) of DBP
8) Confidence 0.41 Published 1999 Journal Pediatr Transplant Section Abstract Doc Link 10562973 Disease Relevance 1.00 Pain Relevance 0.10
Active therapy significantly lowered SBP and DBP in both groups by 7-10%.
Negative_regulation (lowered) of DBP
9) Confidence 0.41 Published 1991 Journal J Hum Hypertens Section Abstract Doc Link 2072368 Disease Relevance 0.43 Pain Relevance 0.06
In the hypertensive subgroup, blood pressure (SBP/DBP) was reduced from a mean baseline value of 175 +/- 22/97 +/- 14 mm Hg to 152 +/- 17/85 +/- 11 mm Hg at 3 months and 149 +/- 23/81 +/- 11 mm Hg after 12 months of treatment.
Negative_regulation (reduced) of DBP in blood associated with hypertension
10) Confidence 0.18 Published 1990 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1369703 Disease Relevance 0.68 Pain Relevance 0.08
No significant difference in immunogenicity results between these two groups (HTRIG/HDCV and HRIG/HDCV) was observed, and no interference of immune globulin with vaccine was reported.
Neg (no) Negative_regulation (interference) of immune globulin
11) Confidence 0.11 Published 1998 Journal Biologicals Section Abstract Doc Link 9637744 Disease Relevance 0.56 Pain Relevance 0.07
Conversely, TU treatment was associated with a significant decrease in sex hormoneĀ–binding globulin, follicular-stimulating hormone, and luteinizing hormone (all p <0.001).
Negative_regulation (decrease) of globulin
12) Confidence 0.02 Published 2008 Journal Am J Cardiol Section Body Doc Link PMC2258313 Disease Relevance 0.29 Pain Relevance 0.03

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