INT83392

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Context Info
Confidence 0.54
First Reported 1999
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 5.07
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
plasma 3
hypothalamus 1
neurons 1
afferent neurons 1
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 16 98.96 Very High Very High Very High
fluoxetine 4 98.12 Very High Very High Very High
vagus nerve 5 95.76 Very High Very High Very High
qutenza 7 89.96 High High
Cholecystokinin 8 88.92 High High
Serotonin 5 88.88 High High
withdrawal 1 83.80 Quite High
Neurotransmitter 2 83.76 Quite High
Neuropeptide 2 83.28 Quite High
anesthesia 4 81.16 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1 99.96 Very High Very High Very High
Pancreatitis 12 99.68 Very High Very High Very High
Acute Necrotizing Pancreatitis 8 99.68 Very High Very High Very High
Ganglion Cysts 2 99.24 Very High Very High Very High
Cancer 4 98.64 Very High Very High Very High
Necrosis 5 98.40 Very High Very High Very High
Body Weight 33 95.40 Very High Very High Very High
Obesity 20 94.64 High High
Suicidal Behaviour 3 91.04 High High
Ulcers 21 89.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This can be explained because hypothyroid rats had an enhanced transcription of mRNA for leptin21 and its concentration in serum.22 Leptin acts on the hypothalamus producing an anorexigenic effect so that hypothyroid pups have a lower appetite than euthyroid animals.
Transcription (transcription) of leptin21 in hypothalamus
1) Confidence 0.54 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874337 Disease Relevance 0.49 Pain Relevance 0.03
Plasma leptin levels were reduced after both 4 hours and 7 days of fluoxetine administration in lean and after 7 days in fatty rats (all p<0.01).
Transcription (levels) of leptin in Plasma associated with fluoxetine
2) Confidence 0.53 Published 1999 Journal Horm. Metab. Res. Section Abstract Doc Link 10437624 Disease Relevance 0.34 Pain Relevance 0.60
To see whether the effect on leptin synthesis was specific we also performed immunohistochemistry for GM-CSF and TNF?
Transcription (synthesis) of leptin
3) Confidence 0.53 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.30 Pain Relevance 0.11
Serum leptin levels in the AEP and ANP groups increased after 12 hr and stayed at high levels until 48 hr compared with the control group.
Transcription (levels) of Serum leptin associated with pancreatitis and acute necrotizing pancreatitis
4) Confidence 0.46 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17333355 Disease Relevance 1.62 Pain Relevance 0.15
By using reverse transcription-polymerase chain reaction, mRNAs encoding long (Ob-Rb) and short (Ob-Ra) leptin receptor isoforms were detected in the rat nodose ganglion, which contains the cell bodies of the vagal afferent neurons.
Transcription (detected) of leptin in afferent neurons associated with ganglion cysts and rheumatoid arthritis
5) Confidence 0.43 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11488950 Disease Relevance 0.41 Pain Relevance 0.35
The area of ASA-induced gastric lesions, gastric blood flow (GBF), expression of mRNA and protein of leptin and plasma leptin, gastrin, interleukin-1beta, and tumor necrosis factor-alpha levels were examined.
Spec (examined) Transcription (expression) of leptin in plasma associated with aspirin, necrosis and cancer
6) Confidence 0.26 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15024038 Disease Relevance 0.84 Pain Relevance 0.38
The area of ASA-induced gastric lesions, gastric blood flow (GBF), expression of mRNA and protein of leptin and plasma leptin, gastrin, interleukin-1beta, and tumor necrosis factor-alpha levels were examined.
Spec (examined) Transcription (expression) of leptin in plasma associated with aspirin, necrosis and cancer
7) Confidence 0.26 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15024038 Disease Relevance 0.84 Pain Relevance 0.38
Leptin receptor mRNA is expressed within the PVN (which is where the cell bodies of neurons that release TRH are located) but not in the TMN (which is the origin of histaminergic neurons) (Flier and Maratos-Flier 1998; Mantzoros 1999; Nillni et al. 2000).
Neg (not) Transcription (expressed) of Leptin in neurons
8) Confidence 0.20 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.23 Pain Relevance 0.03

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