INT8340

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Context Info
Confidence 0.57
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 49
Total Number 53
Disease Relevance 35.96
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SHBG)
Anatomy Link Frequency
blood 4
Visceral 1
parasympathetic 1
urine 1
arm 1
SHBG (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 19 100.00 Very High Very High Very High
intrathecal 3 99.84 Very High Very High Very High
depression 81 99.66 Very High Very High Very High
Opioid 20 99.36 Very High Very High Very High
addiction 18 98.32 Very High Very High Very High
Clonidine 6 97.04 Very High Very High Very High
withdrawal 10 96.08 Very High Very High Very High
chronic noncancer pain 1 94.52 High High
antagonist 18 94.28 High High
backache 5 94.04 High High
Disease Link Frequency Relevance Heat
Obesity 655 99.98 Very High Very High Very High
Heart Disease 16 99.96 Very High Very High Very High
Anovulation 12 99.96 Very High Very High Very High
Nicotine Addiction 24 99.92 Very High Very High Very High
Diabetes Mellitus 604 99.80 Very High Very High Very High
Depression 105 99.66 Very High Very High Very High
Hypertension 787 99.48 Very High Very High Very High
Morbid Obesity 5 99.48 Very High Very High Very High
Metabolic Syndrome 98 99.24 Very High Very High Very High
Respiratory Failure 5 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 30% reduction of the baseline SBP or a HR below 40 bpm was considered an important HE.
Negative_regulation (reduction) of SBP
1) Confidence 0.57 Published 1995 Journal J Clin Anesth Section Body Doc Link 7576677 Disease Relevance 0 Pain Relevance 0
RESULTS: HR, SBP, DBP, and MAP were significantly decreased after propofol administration by 8.5%, 33%, 23%, and 26%, respectively, as compared with the pre-anesthesia control values.
Negative_regulation (decreased) of SBP
2) Confidence 0.57 Published 2010 Journal Acta Anaesthesiol Scand Section Body Doc Link 20236098 Disease Relevance 0 Pain Relevance 0
Active therapy significantly lowered SBP and DBP in both groups by 7-10%.
Negative_regulation (lowered) of SBP
3) Confidence 0.57 Published 1991 Journal J Hum Hypertens Section Abstract Doc Link 2072368 Disease Relevance 0.42 Pain Relevance 0.06
The total extent of both SBP and DBP reduction was equal in all age groups and showed no dependency of the initial blood pressure value.
Negative_regulation (reduction) of SBP in blood
4) Confidence 0.57 Published 1990 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 11527125 Disease Relevance 0.38 Pain Relevance 0.10
PROP was associated with the most decrease in SBP and DBP and in addition respiratory depression (p less than 0.05).
Negative_regulation (decrease) of SBP in respiratory associated with depression and respiratory failure
5) Confidence 0.57 Published 1987 Journal Can J Anaesth Section Abstract Doc Link 3499244 Disease Relevance 0.35 Pain Relevance 0.14
After administration of GTN, SBP was decreased significantly from 157 +/- 25 to 142 +/- 23 mmHg (P < 0.01), while DBP did not change (83 +/- 13 vs 84 +/- 15 mmHg).
Negative_regulation (decreased) of SBP
6) Confidence 0.57 Published 1993 Journal Angiology Section Abstract Doc Link 8285372 Disease Relevance 0.58 Pain Relevance 0.22
The figures concerning free testosterone are even higher as would be expected in view of the concurrent decrease in SHBG levels (Harman et al 2001).
Negative_regulation (decrease) of SHBG
7) Confidence 0.50 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 0.57 Pain Relevance 0
Sex hormone-binding globulin levels were elevated at baseline and decreased modestly with treatment (P < .05 vs. baseline at 5 mg/day; P < .01 vs. baseline at 7.5 mg/day).
Negative_regulation (decreased) of Sex hormone-binding globulin
8) Confidence 0.47 Published 2006 Journal J Pain Section Abstract Doc Link 16516826 Disease Relevance 0.22 Pain Relevance 0.30
Factors such as lack of ability, poor sex education, and psychological conflicts play an important role in the development of sexual dysfunction at the start of sexual activity.1,2 Life habits and morbid conditions become important risk factors for sexual dysfunction during aging; these factors include hypertension, diabetes, depression, heart disease, sex hormone deficiency, smoking, sedentary life style, and drug addiction.3 Socioeconomic factors, such as education, employment and marital status, have also been related to sexual difficulties.4
Negative_regulation (deficiency) of sex hormone in heart associated with drug dependence, nicotine addiction, aging, depression, diabetes mellitus, addiction, reprotox - general 2, heart disease and hypertension
9) Confidence 0.43 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882546 Disease Relevance 1.77 Pain Relevance 0.17
Moreover, data from a randomised, double-blind, placebo-controlled, dose-finding study in 1038 patients with mild to moderate hypertension showed that the greatest reductions in SBP/DBP were achieved by candesartan cilexetil 16 mg/hydrochlorothiazide 12.5 mg.
Negative_regulation (reductions) of SBP associated with hypertension
10) Confidence 0.42 Published 2002 Journal Drugs Section Abstract Doc Link 11929332 Disease Relevance 0.40 Pain Relevance 0.03
At the end of treatment (week 6), there were statistically significant decreases (p less than 0.01) in supine SBP and DBP in both groups compared with baseline values: the mean SBP in groups A and B decreased from 160.0 +/- 14.7 to 133.6 +/- 10.0 mm Hg and from 161.6 +/- 17.8 to 134.8 +/- 10.9 mm Hg, respectively; the mean DBP in groups A and B decreased from 101.3 +/- 3.0 to 83.6 +/- 5.5 mm Hg and from 101.3 +/- 8.4 to 84.2 +/- 3.6 mm Hg, respectively.
Negative_regulation (decreases) of SBP
11) Confidence 0.42 Published 1992 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1376836 Disease Relevance 0.40 Pain Relevance 0.06
SBP, DBP, MBP and HR mean values have significantly decreased as compared to control as from 15 min after local anesthetic injection, thus characterizing hypotensive anesthesia.
Negative_regulation (decreased) of SBP
12) Confidence 0.42 Published 2002 Journal Rev Bras Anestesiol Section Body Doc Link 19475210 Disease Relevance 0.06 Pain Relevance 0
The results indicated that TP compression (1) decreased HR, SBP and DBP, (2) increased parasympathetic activity, (3) increased the gain from ILV to HR, and (4) improved the fatigue scores.
Negative_regulation (decreased) of SBP in parasympathetic associated with fatigue
13) Confidence 0.42 Published 2009 Journal J Physiol Sci Section Abstract Doc Link 19340540 Disease Relevance 0.27 Pain Relevance 0
In the hypertensive subgroup, blood pressure (SBP/DBP) was reduced from a mean baseline value of 175 +/- 22/97 +/- 14 mm Hg to 152 +/- 17/85 +/- 11 mm Hg at 3 months and 149 +/- 23/81 +/- 11 mm Hg after 12 months of treatment.
Negative_regulation (reduced) of SBP in blood associated with hypertension
14) Confidence 0.41 Published 1990 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1369703 Disease Relevance 0.68 Pain Relevance 0.08
Mean DBP and SBP reductions were apparent from week 4 and maintained throughout the treatment period.
Negative_regulation (reductions) of SBP
15) Confidence 0.41 Published 2003 Journal J. Int. Med. Res. Section Abstract Doc Link 14708422 Disease Relevance 0.33 Pain Relevance 0.09
The drug reduced SBP in high IT, whereas it reduced SBP plus DBP and NE in low IT subjects.
Negative_regulation (reduced) of SBP
16) Confidence 0.41 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2986025 Disease Relevance 0 Pain Relevance 0.30
Low testosterone may be a predictive marker for those at high risk of cardiovascular disease.8 Thus, lower testosterone levels, erectile dysfunction and conditions associated with higher cardiovascular risk appear to be interrelated.210,211 Obesity induces a decrease of T levels via a decrease in SHBG levels, and morbid obesity also induces a decrease of FT.212 There is evidence to suggest that an inverse relationship exists between serum testosterone levels and the degree of obesity in men.213,214 There is a close relationship between obesity and low serum testosterone levels in healthy men.215 Twenty percent to 64% of obese men have a low serum total or free testosterone level.216 Visceral obesity is more strongly inversely related to total and free testosterone levels than other forms of obesity.217,218 The Relationship between reduced testosterone and obesity in men can be explained by the hypogonadal-cytokine-obesity cycle219,220 and it exhibits antiatherogenic effects at the tissue level, whether mediated by classical or nonclassical pathways.221,222
Negative_regulation (decrease) of SHBG in Visceral associated with reprotox - general 2, morbid obesity, cardiovascular disease, obesity, metabolic syndrome and cytokine
17) Confidence 0.39 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701485 Disease Relevance 1.91 Pain Relevance 0.04
From a practical point of view, the diagnosis of HSDD should encompass the major biological causes such as states of sex hormone deficiency, especially low androgens, mood disorders, including anxiety and depression, and many clinical conditions and related medications with a potential impact on women’s sexual function.
Negative_regulation (deficiency) of sex hormone associated with depression, affective disorder, anxiety disorder and hypoactive sexual desire disorder
18) Confidence 0.39 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971736 Disease Relevance 1.25 Pain Relevance 0.15
However, when endogenous inhibitory mechanisms are tonically activated by situational variables, such as stress and fatigue, and/or by compounds that reinforce inhibition (ie, selective serotonin reuptake inhibitors [SSRIs]) or, alternatively, sexual excitatory mechanisms are endogenously blunted, as it may occur in some hormonal and/or metabolic conditions, several amounts of FSD may be present and sexual symptoms may be co-occurring in the same woman.25 Therefore, even though psychorelational issues and sociocultural factors should always be ruled out, there is no doubt that biological aspects, including sex hormone deficiency, as well as other medical conditions and medications which may cause a neuroendocrine imbalance, play a major role in the clinical manifestation of sexual problems that induce personal distress and, therefore, may require intervention.26,27 Indeed, the iatrogenic removal of both ovaries, which may occur well before the age of natural menopause, is characterized by the effects of acute estrogen and even androgen deprivation in several domains of sexual function (desire, arousal, lubrication, orgasm, satisfaction) and has been significantly associated with HSDD and severity of other menopausal symptoms such as vaginal dryness.28–30 Following bilateral oophorectomy, both premenopausally and postmenopausally, there is a sudden 50% fall in circulating testosterone (T) levels which have been associated with the so-called androgen-insufficiency syndrome; an increasingly accepted clinical entity comprising specific symptoms such as low sexual desire, persistent and inexplicable fatigue, blunted motivation and a general reduced sense of well-being.31 It is also known that T significantly declines with age, independently from the menopausal transition, because of a progressive reduction of adrenal production.
Negative_regulation (deficiency) of sex hormone in ovaries associated with female sexual arousal disorder, stress, endometriosis (extended), syndrome, hypoactive sexual desire disorder, reprotox - general 2, iatrogenic, reprotox - general 3, fatigue and ssri
19) Confidence 0.39 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971736 Disease Relevance 0.90 Pain Relevance 0.24
Tibolone lowers sex hormone-binding globulin (SHBG) and increases circulating free testosterone, adding to its androgenicity.
Negative_regulation (lowers) of SHBG
20) Confidence 0.39 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971736 Disease Relevance 0.68 Pain Relevance 0.03

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